公开(公告)号：US20240254221A1

公开(公告)日：2024-08-01

申请号：US18383043

申请日：2023-10-23

Applicant: Singapore Health Services PTE LTD ,  Agency for Science, Technology and Research

Inventor： Hau Wan LEUNG ,  Andre Boon Hwa Choo ,  Mei Yee Vanessa Ding ,  Shao Weng Daniel Tan ,  Narayanan Gopalakrishna Iyer

IPC: C07K16/28 ,  A61K39/00 ,  A61K47/64 ,  A61K47/68 ,  A61K51/10 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  G01N33/574

CPC classification number: C07K16/2803 ,  A61K47/6415 ,  A61K47/6857 ,  A61K51/1048 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  G01N33/57473 ,  A61K2039/505 ,  A61K2039/55 ,  C07K2317/732

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US20190233514A1

公开(公告)日：2019-08-01

申请号：US16341052

申请日：2017-10-10

Applicant: Singapore Health Services PTE LTD ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Hau Wan LEUNG ,  Andre Boon Hwa CHOO ,  Mei Yee vanessa DING ,  Shao Weng Daniel Tan ,  Narayanan Gopalakrishna Iyer

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  A61K47/64 ,  A61K47/68 ,  G01N33/574 ,  A61K51/10

CPC classification number: C07K16/2803 ,  A61K47/6415 ,  A61K47/6857 ,  A61K51/1048 ,  A61K2039/505 ,  A61K2039/55 ,  A61P35/00 ,  C07K16/30 ,  C07K16/44 ,  C07K2317/732 ,  G01N33/57473

Abstract: The present invention relates to an antigen-binding protein, or an antigen-binding fragment thereof which binding to CEACAM6, comprising (i) a heavy chain variable domain comprising a VHCDR1 having the amino acid sequence GNTFTSYVMH; a VHCDR2 having the amino acid sequence YINPYNDGTKYNEKFKG; and a VHCDR3 having the amino acid sequence STARATPYFYAMDY and (ii) a light chain variable domain comprising a VLCDR1 having the amino acid sequence KSSQSLLWSVNQNSYLS, a VLCDR2 having the amino acid sequence GASIRES, and a VLCDR3 having the amino acid sequence QHNHGSFLPYT. The present invention also relates to compositions comprising the antigen-binding protein, or antigen-binding fragment thereof, methods of use of the antigen-binding protein, or antigen-binding fragment thereof for cancer treatment, prevention or detection and a kit comprising the antigen-binding protein, or antigen-binding fragment thereof.

公开(公告)号：US20240238433A1

公开(公告)日：2024-07-18

申请号：US18562788

申请日：2022-05-20

Applicant: Agency for Science, Technology and Research

Inventor： Boon Hwa Andre CHOO ,  Ting Hwee GOH ,  Mei Yee DING ,  Hau Wan LEUNG ,  Simone DORFMUELLER ,  Ban Xiong TAN ,  Chek Shik LIM ,  Walter STUNKEL

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  G01N33/574 ,  G01N33/58

CPC classification number: A61K47/68031 ,  A61K47/6849 ,  A61P35/00 ,  C07K16/2803 ,  G01N33/57492 ,  G01N33/58 ,  C07K2317/565 ,  C07K2317/567

Abstract: The invention relates to anti-CEACAM5/6 antigen-binding molecules and humanized variants thereof that bind to CEACAM5/6 that is glycosylated at N256. It also relates to the use of said antigen-binding molecules in methods of detection and medical treatment thereof.