公开(公告)号：US20170328837A1

公开(公告)日：2017-11-16

申请号：US15604342

申请日：2017-05-24

Applicant: Agency for Science, Technology and Research

Inventor： Kiang Wei Kho ,  Olivo Malini

IPC: G01N21/65 ,  G01N33/553 ,  G01N33/543 ,  G01N33/58 ,  G01N33/532

CPC classification number: G01N21/658 ,  G01N33/532 ,  G01N33/54373 ,  G01N33/553 ,  G01N33/58

Abstract: The present invention relates to method detecting analytes by surface enhanced Raman spectroscopy (SERS), comprising contacting the analytes with at least one analyte binding molecule attached to a metal substrate surface that enhances Raman scattering via a Raman-active molecular linker; and detecting a surface enhanced Raman signal from said compound. In a further aspect, this invention relates to a conjugate and a biosensor suitable for the invented SERS-based analyte detection method.