公开(公告)号：US20230257444A1

公开(公告)日：2023-08-17

申请号：US18014992

申请日：2021-07-15

Applicant: Agency for Science, Technology and Research

Inventor： Linus Wei Jie Lim ,  Yue Wang ,  Say Kong Ng ,  Kong Peng Lam

IPC: C07K14/705

CPC classification number: C07K14/7056 ,  C07K2319/30

Abstract: The present invention relates to a soluble dimeric fusion protein comprising a first and second polypeptides, wherein the first and second polypeptides each comprises a Dectin-1 receptor polypeptide fused to a human Fc domain via a dimerization linker. Methods of using the soluble dimeric fusion protein for immunizing a subject against a fungal infection, preventing or treating a fungal infection in a subject and detecting a fungal infection in a subject are also provided. In one embodiment, a chimeric molecule comprising the fusion protein and a payload is provided. In one embodiment, the payload is Amphotericin B.

公开(公告)号：US20220251619A1

公开(公告)日：2022-08-11

申请号：US17598965

申请日：2020-03-23

Applicant: Agency For Science, Technology And Research ,  The University of Manchester

Inventor： Sern Farh Matthew Choo ,  Terry Nguyen-Khuong ,  Edward George Pallister ,  Say Kong Ng ,  Sabine Lahja Flitsch

IPC: C12P21/00 ,  C07K1/107

Abstract: The invention relates to a method of increasing the number of α2,3,-α2,6-disialylgalactose N-glycans on a glycoprotein by incubating an α2,3-sialylated glycoprotein with an α2,6-sialyltransferase and a sialic acid source. Also provided is a recombinant glycoprotein comprising at least one α2,3,-α2,6-disialylgalactose N-glycan. In a particular embodiment, the recombinant glycoprotein is alpha-1 antitrypsin (AAT).