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    FUSION PROTEIN AND COMBINATIONS THEREOF
    1.
    发明公开
    FUSION PROTEIN AND COMBINATIONS THEREOF 审中-公开

    公开(公告)号：US20230257444A1

    公开(公告)日：2023-08-17

    申请号：US18014992

    申请日：2021-07-15

    Applicant: Agency for Science, Technology and Research

    Inventor： Linus Wei Jie Lim ,  Yue Wang ,  Say Kong Ng ,  Kong Peng Lam

    IPC: C07K14/705

    CPC classification number: C07K14/7056 ,  C07K2319/30

    Abstract: The present invention relates to a soluble dimeric fusion protein comprising a first and second polypeptides, wherein the first and second polypeptides each comprises a Dectin-1 receptor polypeptide fused to a human Fc domain via a dimerization linker. Methods of using the soluble dimeric fusion protein for immunizing a subject against a fungal infection, preventing or treating a fungal infection in a subject and detecting a fungal infection in a subject are also provided. In one embodiment, a chimeric molecule comprising the fusion protein and a payload is provided. In one embodiment, the payload is Amphotericin B.

    Monoclonal antibody against muramyl peptides
    2.
    发明授权
    Monoclonal antibody against muramyl peptides 有权

    公开(公告)号：US10316079B2

    公开(公告)日：2019-06-11

    申请号：US15600203

    申请日：2017-05-19

    Applicant: Agency for Science, Technology and Research

    Inventor： Yue Wang ,  Xiaoli Xu

    IPC: C07K16/12 ,  C07K16/44 ,  A61K39/00 ,  G01N33/566

    Abstract: Disclosed is an isolated antibody or an antigen-binding fragment thereof The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.

    Automatic region-of-interest segmentation and registration of dynamic contrast-enhanced images of colorectal tumors
    6.
    发明授权
    Automatic region-of-interest segmentation and registration of dynamic contrast-enhanced images of colorectal tumors 有权

    公开(公告)号：US10176573B2

    公开(公告)日：2019-01-08

    申请号：US15519145

    申请日：2014-10-13

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： Zujun Hou ,  Yue Wang

    IPC: G06T7/00 ,  G06K9/46 ,  G06T7/73 ,  G06T7/12 ,  G06T7/33 ,  G06T7/246 ,  G01R33/56

    Abstract: A method for dynamic contrast enhanced (DCE) image processing and kinetic modeling of an organ's region-of-interest is provided. The method includes deriving at least a contour of an exterior of the organ's region-of-interest from one or more of a plurality of images; generating a spline function in response to the derived contour of the exterior of the organ's region-of-interest from the one or more of the plurality of images; registering the plurality of images wherein the organ's region-of-interest has been segmented; deriving a tracer curve for the organ's region-of-interest in the registered images, the tracer curve indicating a change in concentration of a contrast agent flowing through the organ's region-of-interest over a time period; and kinetic modeling by fitting a kinetic model to the tracer curve to generate one or more maps of tissue physiological parameters associated with the kinetic model.

    MONOCLONAL ANTIBODY AGAINST MURAMYL PEPTIDES
    10.
    发明申请
    MONOCLONAL ANTIBODY AGAINST MURAMYL PEPTIDES 有权
    单克隆抗体对MURAMYL PEPTIDES

    公开(公告)号：US20150344547A1

    公开(公告)日：2015-12-03

    申请号：US14436002

    申请日：2013-11-01

    Applicant: AGENCY FOR SCIENCE TECHNOLOGY AND RESEARCH

    Inventor： Yue Wang ,  Xiaoli Xu

    IPC: C07K16/12

    CPC classification number: C07K16/12 ,  C07K16/1232 ,  C07K16/1275 ,  C07K16/44 ,  C07K2317/92 ,  G01N33/566 ,  G01N2333/4722

    Abstract: Disclosed is an isolated antibody or an antigen-binding fragment thereof. The antibody is capable of binding to a muramyl peptide, or a derivative or an analog or a salt thereof. The muramyl peptide comprises muramic acid and an amino acid selected from the group consisting of alanine, isoglutamine, glutamic acid, and a salt thereof. Also disclosed are methods of producing the antibody, compositions comprising the antibody, methods of treating using the antibody, uses of the antibody, methods of detecting muramyl peptide, an assay for detecting muramyl peptide, an antibacterial agent, hybridomas and kits.

    Abstract translation: 公开了分离的抗体或其抗原结合片段。 该抗体能够结合胞壁酰肽或其衍生物或类似物或其盐。 胞壁酰基肽包括胞壁酸和选自丙氨酸，异谷氨酰胺，谷氨酸及其盐的氨基酸。 还公开了制备抗体的方法，包含抗体的组合物，使用抗体的治疗方法，抗体的使用，检测胞壁酰肽的方法，检测胞壁酰肽的检测方法，抗菌剂，杂交瘤和试剂盒。

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