公开(公告)号：US20230014036A1

公开(公告)日：2023-01-19

申请号：US17818840

申请日：2022-08-10

申请人： AGENUS INC.

发明人： Dhan Sidhartha Chand ,  Zahra Jawad ,  Olga Ignatovich ,  Nicola Anne Ramsay ,  Spencer Campbell ,  Beth Wensley ,  Emmanuel Cyrille Pascal Briend ,  K. Mark Bushell ,  Benjamin Maxime Morin ,  Veronica Franciszka Ilkow

IPC分类号： C07K16/28 ,  A61P35/00

摘要： The instant disclosure provides multispecific molecules that specifically bind to CD96 (e.g., human CD96) and/or TIGIT (e.g., human TIGIT) and isolated antibodies that specifically bind to TIGIT (e.g., human TIGIT). Also provided are pharmaceutical compositions comprising these multispecific molecules and antibodies, nucleic acids encoding these multispecific molecules and antibodies, expression vectors and host cells for making these multispecific molecules and antibodies, and methods of treating a subject using these multispecific molecules and antibodies.

公开(公告)号：US20210101977A1

公开(公告)日：2021-04-08

申请号：US17007238

申请日：2020-08-31

申请人： Agenus Inc.

发明人： Dhan Sidhartha Chand ,  Randi Barbara Gombos ,  Olga Ignatovich ,  Nicola Anne Ramsay ,  K. Mark Bushell ,  Emmanuel Cyrille Pascal Briend

IPC分类号： C07K16/28 ,  A61K47/68

摘要： The instant disclosure provides antibodies that specifically bind to CD96 (e.g., human CD96) and antagonize CD96 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.