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公开(公告)号：US20210130495A1
公开(公告)日：2021-05-06
申请号：US17035015
申请日：2020-09-28
申请人： Agenus Inc.
IPC分类号： C07K16/42
摘要： Provided herein are heterodimeric proteins (e.g., multispecific antibodies) that exhibit enhanced binding to human Fc gamma receptor IIIA (FcγRIIIA) relative to naturally occurring antibodies and retain good manufacturability. Such heterodimeric proteins are particular useful as multispecific binding proteins (e.g., multispecific antibodies). Also provided are pharmaceutical compositions comprising these heterodimeric proteins, nucleic acids encoding these heterodimeric proteins, and expression vectors and host cells for making these heterodimeric proteins.
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公开(公告)号：US20210106693A1
公开(公告)日：2021-04-15
申请号：US17094196
申请日：2020-11-10
申请人： Agenus Inc.
发明人： Yanping Xiao , Nicholas Stuart Wilson , Benjamin Maxime Morin , Mark Arthur Findeis , Cornelia Anne Mundt , Marc van Dijk , Dhan Sidhartha Chand , David Adam Savitsky , Dennis John Underwood , Olga Ignatovich
摘要： The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20180355040A1
公开(公告)日：2018-12-13
申请号：US15968094
申请日：2018-05-01
申请人： Agenus Inc.
CPC分类号： C07K16/2818 , A61K39/395 , A61K2039/57 , A61P35/04 , C07K16/28 , C07K16/2875 , C07K16/2878 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/73 , C07K2317/734 , C07K2317/74 , C07K2317/76 , C07K2317/92 , C07K2319/30 , G01N33/505
摘要： The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20230014036A1
公开(公告)日：2023-01-19
申请号：US17818840
申请日：2022-08-10
申请人： AGENUS INC.
发明人： Dhan Sidhartha Chand , Zahra Jawad , Olga Ignatovich , Nicola Anne Ramsay , Spencer Campbell , Beth Wensley , Emmanuel Cyrille Pascal Briend , K. Mark Bushell , Benjamin Maxime Morin , Veronica Franciszka Ilkow
摘要： The instant disclosure provides multispecific molecules that specifically bind to CD96 (e.g., human CD96) and/or TIGIT (e.g., human TIGIT) and isolated antibodies that specifically bind to TIGIT (e.g., human TIGIT). Also provided are pharmaceutical compositions comprising these multispecific molecules and antibodies, nucleic acids encoding these multispecific molecules and antibodies, expression vectors and host cells for making these multispecific molecules and antibodies, and methods of treating a subject using these multispecific molecules and antibodies.
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公开(公告)号：US11098117B2
公开(公告)日：2021-08-24
申请号：US17094196
申请日：2020-11-10
申请人： Agenus Inc.
发明人： Yanping Xiao , Nicholas Stuart Wilson , Benjamin Maxime Morin , Mark Arthur Findeis , Cornelia Anne Mundt , Marc van Dijk , Dhan Sidhartha Chand , David Adam Savitsky , Dennis John Underwood , Olga Ignatovich
IPC分类号： C07K16/28 , C12N15/09 , A61K47/68 , A61K39/395 , A61K45/06 , A61K51/10 , C07K16/46 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US11021537B2
公开(公告)日：2021-06-01
申请号：US15968094
申请日：2018-05-01
申请人： Agenus Inc.
摘要： The instant disclosure provides antibodies that specifically bind to T-cell immunoreceptor with Ig and ITIM domains (TIGIT) (e.g., human TIGIT) and antagonize TIGIT function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US11242385B2
公开(公告)日：2022-02-08
申请号：US15951950
申请日：2018-04-12
申请人： Agenus Inc.
发明人： Yanping Xiao , Nicholas Stuart Wilson , Benjamin Maxime Morin , Mark Arthur Findeis , Cornelia Anne Mundt , Marc van Dijk , Dhan Sidhartha Chand , David Adam Savitsky , Dennis John Underwood , Olga Ignatovich
IPC分类号： C12N15/13 , C07K16/28 , C12N15/09 , A61K47/68 , A61K39/395 , A61K45/06 , A61K51/10 , C07K16/46 , A61K39/00
摘要： The instant disclosure provides antibodies that specifically bind to CD137 (e.g., human CD137) and increases CD137 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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公开(公告)号：US20210101977A1
公开(公告)日：2021-04-08
申请号：US17007238
申请日：2020-08-31
申请人： Agenus Inc.
发明人： Dhan Sidhartha Chand , Randi Barbara Gombos , Olga Ignatovich , Nicola Anne Ramsay , K. Mark Bushell , Emmanuel Cyrille Pascal Briend
摘要： The instant disclosure provides antibodies that specifically bind to CD96 (e.g., human CD96) and antagonize CD96 function. Also provided are pharmaceutical compositions comprising these antibodies, nucleic acids encoding these antibodies, expression vectors and host cells for making these antibodies, and methods of treating a subject using these antibodies.
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