公开(公告)号：US20220214334A1

公开(公告)日：2022-07-07

申请号：US17606915

申请日：2020-04-30

Applicant: Agilent Technologies, Inc.

Inventor： Andres Guerrero Navarro

IPC: G01N33/533 ,  G01N30/06

Abstract: The present invention provides methods to improve the sensitivity of detecting glycosylamines released from glycoconjugates, such as glycoproteins or glycopeptides, by enzymatic digestion when labeling them with amine-reactive dyes.

公开(公告)号：US11376200B2

公开(公告)日：2022-07-05

申请号：US16965915

申请日：2019-01-31

Applicant: Agilent Technologies, Inc.

Inventor： Sergey Vlasenko ,  Francis T. Haxo ,  Andres Guerrero Navarro

IPC: A61K8/36 ,  A61K31/196 ,  G01N33/50 ,  G01N21/64 ,  C07C63/06 ,  C08B37/00

Abstract: The present disclosure provides methods for using anthranilic acid (2-AA) blocked by tertbutyloxycarbonyl (Boc) groups in protocols for labeling glycans for analysis, and kits providing 2-AA-Boc and acids for unblocking blocked 2-AA for use in glycan labeling and analysis.

公开(公告)号：US11371998B2

公开(公告)日：2022-06-28

申请号：US16495024

申请日：2019-09-17

Applicant: Agilent Technologies, Inc.

Inventor： Andres Guerrero Navarro

IPC: G01N33/58 ,  C07H1/00 ,  C07H3/06 ,  G01N21/64 ,  B01L3/00 ,  G01N1/34 ,  G01N1/40

Abstract: The present invention provides methods, devices, and kits to improve procedures for reducing carbohydrates, such as glycans released from glycoconjugates, or for labeling carbohydrates by reductive amination.