公开(公告)号：US10730854B2

公开(公告)日：2020-08-04

申请号：US16121483

申请日：2018-09-04

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta ,  Chong-Hui Gu ,  David Schenkein ,  Hua Yang ,  Liting Guo ,  Zhen Tang ,  Jianming Wang ,  Yanfeng Zhang ,  Yan Zhou

IPC分类号： C07D401/14 ,  A61K31/53 ,  A61P35/00 ,  A61K31/444 ,  A61K9/20

摘要： Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

公开(公告)号：US20170305885A1

公开(公告)日：2017-10-26

申请号：US15649551

申请日：2017-07-13

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta ,  Chong-Hui Gu ,  David Schenkein ,  Hua Yang ,  Liting Guo ,  Zhen Tang ,  Jianming Wang ,  Yanfeng Zhang ,  Yan Zhou

IPC分类号： C07D401/14 ,  A61K9/20 ,  A61K31/444 ,  A61K31/53

CPC分类号： C07D401/14 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/444 ,  A61K31/53 ,  C07B2200/13

摘要： Provided are compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein.

公开(公告)号：US20180370951A1

公开(公告)日：2018-12-27

申请号：US16121483

申请日：2018-09-04

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta ,  Chong-Hui Gu ,  David Schenkein ,  Hua Yang ,  Liting Guo ,  Zhen Tang ,  Jianming Wang ,  Yanfeng Zhang ,  Yan Zhou

IPC分类号： C07D401/14 ,  A61K31/53 ,  A61K9/20 ,  A61K31/444

摘要： Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.

公开(公告)号：US10093654B2

公开(公告)日：2018-10-09

申请号：US15649551

申请日：2017-07-13

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta ,  Chong-Hui Gu ,  David Schenkein ,  Hua Yang ,  Liting Guo ,  Zhen Tang ,  Jianming Wang ,  Yanfeng Zhang ,  Yan Zhou

IPC分类号： C07D401/14 ,  A61K31/53 ,  A61P35/00 ,  A61K31/444 ,  A61K9/20

摘要： Provided are compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein.

公开(公告)号：US09738625B2

公开(公告)日：2017-08-22

申请号：US14909451

申请日：2014-08-01

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta ,  Chong-Hui Gu ,  David Schenkein ,  Hua Yang ,  Liting Guo ,  Zhen Tang ,  Jianming Wang ,  Yanfeng Zhang ,  Yan Zhou

IPC分类号： C07D401/14 ,  A61K31/53 ,  A61P35/00 ,  A61K31/444 ,  A61K9/20

CPC分类号： C07D401/14 ,  A61K9/2054 ,  A61K9/2059 ,  A61K31/444 ,  A61K31/53 ,  C07B2200/13

摘要： Provided are isocitrate dehydrogenase 2 (IDH2) inhibitor compounds useful for treating cancer and methods of treating cancer, comprising administering to a subject in need thereof a compound described herein. Also provided are polymorphic forms of the IDH2 inhibitor compounds characterized by X Ray powder diffraction patterns, having improved physicochemical properties that influence in vivo dissolution rate for formulation purposes.

公开(公告)号：US20210155603A1

公开(公告)日：2021-05-27

申请号：US16915936

申请日：2020-06-29

申请人： Agios Pharmaceuticals, Inc.

发明人： Samuel V. Agresta ,  Chong-Hui Gu ,  David Schenkein ,  Hua Yang ,  Liting Guo ,  Zhen Tang ,  Jianming Wang ,  Yanfeng Zhang ,  Yan Zhou

IPC分类号： C07D401/14 ,  A61K9/20 ,  A61K31/53 ,  A61P35/00 ,  A61K31/444

摘要： Provided are compounds useful for treating of cancer and methods for treating of cancer, comprising administering to a subject in need thereof a compound described therein.