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    Derivatives of dioxane-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
    1.
    发明授权
    Derivatives of dioxane-2-alkyl carbamates, preparation thereof and application thereof in therapeutics 有权
    二恶烷-2-烷基氨基甲酸酯的衍生物，其制备及其在治疗中的应用

    公开(公告)号：US07119116B2

    公开(公告)日：2006-10-10

    申请号：US11062541

    申请日：2005-02-22

    申请人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    发明人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    IPC分类号： A61K31/36 ,  C07D319/06

    CPC分类号： C07D319/06 ,  C07C235/06 ,  C07D405/12

    摘要： A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1–C3)alkyl, (C1–C3)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C3–C6)cycloalkyl-O— or (C3–C6)cycloalkyl(C1–C3)alkoxy groups; R2 represents either a group of general formula CHR3CONHR4 in which R3 represents a hydrogen atom or a methyl group and R4 represents a hydrogen atom or a (C1–C3)alkyl, (C3–C5)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C1–C3)alkyl, (C1–C3)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

    摘要翻译： 对应于通式（I）的化合物：其中R 1表示任选被一个或多个卤素原子或羟基取代的苯基或萘基，氰基，硝基，（C 1） （C 1 -C 3）烷基，（C 1 -C 3 -C 3）烷氧基，三氟甲基，三氟甲氧基，苄氧基，（C 3 H 3） C 1 -C 6环烷基-O-或（C 3 -C 6 -C 6）环烷基（C 1 -C 6） C 1 -C 3烷氧基; R 2表示其中R 3 3表示氢原子的通式为CHR 3 CONHR 4 S的基团，或 甲基和R 4代表氢原子或（C 1 -C 3 -C 3）烷基，（C 3 H 3） （C 1 -C 5）环烷基或（吡啶-4-基）甲基; 或2,2,2-三氟乙基; 或（咪唑-2-基）甲基; 或（苯并咪唑-2-基）甲基; 或任选被一个或多个卤素原子取代的苯基或氰基，硝基，（C 1 -C 3 - ）烷基，（C 1 -C 3）烷基， -C 3 -C 3烷氧基，三氟甲基或三氟甲氧基; n表示1〜3的数; 以碱的形式，与酸的加成盐，水合物或溶剂合物的形式。 还公开并要求保护的是由其衍生的药物组合物及其治疗各种疾病的治疗用途。

    DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS
    2.
    发明申请
    DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS 有权
    二氧化-2-烷基碳酸酯的衍生物，其制备方法及其在治疗中的应用

    公开(公告)号：US20100280076A1

    公开(公告)日：2010-11-04

    申请号：US12834268

    申请日：2010-07-12

    申请人： Ahmed ABOUABDELLAH ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    发明人： Ahmed ABOUABDELLAH ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    IPC分类号： A61K31/4433 ,  A61K31/357 ,  A61K31/4184 ,  A61P19/02 ,  A61P19/06 ,  A61P1/00 ,  A61P25/06 ,  A61P25/14 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28

    CPC分类号： C07D319/06 ,  C07C235/06 ,  C07D405/12

    摘要： A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C3-C6)cycloalkyl-O— or (C3-C6)cycloalkyl(C1-C3)alkoxy groups; R2 represents either a group of general formula CHR3CONHR4 in which R3 represents a hydrogen atom or a methyl group and R4 represents a hydrogen atom or a (C1-C3)alkyl, (C3-C5) cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

    摘要翻译： 氰基，硝基，（C1-C3）烷基，（C1-C3）烷氧基，三氟甲基，（C1-C3）烷氧基， 三氟甲氧基，苄氧基，（C3-C6）环烷基-O-或（C3-C6）环烷基（C1-C3）烷氧基; R 2表示通式CHR 3 CONHR 4的基团，其中R 3表示氢原子或甲基，R 4表示氢原子或（C 1 -C 3）烷基，（C 3 -C 5）环烷基或（吡啶-4-基）甲基 组; 或2,2,2-三氟乙基; 或（咪唑-2-基）甲基; 或（苯并咪唑-2-基）甲基; 或任选被一个或多个卤素原子取代的苯基或氰基，硝基，（C 1 -C 3）烷基，（C 1 -C 3）烷氧基，三氟甲基或三氟甲氧基; n表示1〜3的数; 以碱的形式，与酸的加成盐，水合物或溶剂合物的形式。 还公开并要求保护的是由其衍生的药物组合物及其治疗各种疾病的治疗用途。

    Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
    3.
    发明授权
    Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics 有权
    二烷基-2-烷基氨基甲酸酯的衍生物，其制备及其在治疗中的应用

    公开(公告)号：US07777057B2

    公开(公告)日：2010-08-17

    申请号：US12510326

    申请日：2009-07-28

    申请人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    发明人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    IPC分类号： C07D319/06

    CPC分类号： C07D319/06 ,  C07C235/06 ,  C07D405/12

    摘要： A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C3-C6)cycloalkyl-O— or (C3-C6)cycloalkyl(C1-C3)alkoxy groups; R2 represents either a group of general formula CHR3CONHR4 in which R3 represents a hydrogen atom or a methyl group and R4 represents a hydrogen atom or a (C1-C3)alkyl, (C3-C5)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

    摘要翻译： 氰基，硝基，（C1-C3）烷基，（C1-C3）烷氧基，三氟甲基，（C1-C3）烷氧基， 三氟甲氧基，苄氧基，（C3-C6）环烷基-O-或（C3-C6）环烷基（C1-C3）烷氧基; R 2表示通式CHR 3 CONHR 4的基团，其中R 3表示氢原子或甲基，R 4表示氢原子或（C 1 -C 3）烷基，（C 3 -C 5）环烷基或（吡啶-4-基）甲基 组; 或2,2,2-三氟乙基; 或（咪唑-2-基）甲基; 或（苯并咪唑-2-基）甲基; 或任选被一个或多个卤素原子取代的苯基或氰基，硝基，（C 1 -C 3）烷基，（C 1 -C 3）烷氧基，三氟甲基或三氟甲氧基; n表示1〜3的数; 以碱的形式，与酸的加成盐，水合物或溶剂合物的形式。 还公开并要求保护的是由其衍生的药物组合物及其治疗各种疾病的治疗用途。

    Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics
    4.
    发明授权
    Derivatives of dioxan-2-alkyl carbamates, preparation thereof and application thereof in therapeutics 有权
    二烷基-2-烷基氨基甲酸酯的衍生物，其制备及其在治疗中的应用

    公开(公告)号：US08119687B2

    公开(公告)日：2012-02-21

    申请号：US12834268

    申请日：2010-07-12

    申请人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    发明人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    IPC分类号： A61K31/351

    CPC分类号： C07D319/06 ,  C07C235/06 ,  C07D405/12

    摘要： A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C3-C6)cycloalkyl-O— or (C3-C6)cycloalkyl(C1-C3)alkoxy groups; R2 represents either a group of general formula CHR3CONHR4 in which R3 represents a hydrogen atom or a methyl group and R4 represents a hydrogen atom or a (C1-C3)alkyl, (C3-C5) cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

    摘要翻译： 氰基，硝基，（C1-C3）烷基，（C1-C3）烷氧基，三氟甲基，（C1-C3）烷氧基， 三氟甲氧基，苄氧基，（C3-C6）环烷基-O-或（C3-C6）环烷基（C1-C3）烷氧基; R 2表示通式CHR 3 CONHR 4的基团，其中R 3表示氢原子或甲基，R 4表示氢原子或（C 1 -C 3）烷基，（C 3 -C 5）环烷基或（吡啶-4-基）甲基 组; 或2,2,2-三氟乙基; 或（咪唑-2-基）甲基; 或（苯并咪唑-2-基）甲基; 或任选被一个或多个卤素原子取代的苯基或氰基，硝基，（C 1 -C 3）烷基，（C 1 -C 3）烷氧基，三氟甲基或三氟甲氧基; n表示1〜3的数; 以碱的形式，与酸的加成盐，水合物或溶剂合物的形式。 还公开并要求保护的是由其衍生的药物组合物及其治疗各种疾病的治疗用途。

    DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS
    5.
    发明申请
    DERIVATIVES OF DIOXAN-2-ALKYL CARBAMATES, PREPARATION THEREOF AND APPLICATION THEREOF IN THERAPEUTICS 有权
    二氧化-2-烷基碳酸酯的衍生物，其制备方法及其在治疗中的应用

    公开(公告)号：US20090286868A1

    公开(公告)日：2009-11-19

    申请号：US12510326

    申请日：2009-07-28

    申请人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    发明人： Ahmed Abouabdellah ,  Michele Bas ,  Gihad Dargazanli ,  Christian Hoornaert ,  Adrien Tak Li ,  Florence Medaisko

    IPC分类号： A61K31/335 ,  C07D319/06

    CPC分类号： C07D319/06 ,  C07C235/06 ,  C07D405/12

    摘要： A compound corresponding to general formula (I): in which R1 represents a phenyl or naphthalenyl group optionally substituted with one or more halogen atoms or hydroxyl, cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl, trifluoromethoxy, benzyloxy, (C3-C6)cycloalkyl-O— or (C3-C6)cycloalkyl(C1-C3)alkoxy groups; R2 represents either a group of general formula CHR3CONHR4 in which R3 represents a hydrogen atom or a methyl group and R4 represents a hydrogen atom or a (C1-C3)alkyl, (C3-C5)cycloalkyl or (pyridin-4-yl)methyl group; or a 2,2,2-trifluoroethyl group; or an (imidazol-2-yl)methyl group; or a (benzimidazol-2-yl)methyl group; or a phenyl group optionally substituted with one or more halogen atoms or cyano, nitro, (C1-C3)alkyl, (C1-C3)alkoxy, trifluoromethyl or trifluoromethoxy groups; and n represents a number ranging from 1 to 3; in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate. Also disclosed and claimed are the pharmaceutical compositions derived therefrom and their therapeutic use in treating a wide variety of diseases.

    摘要翻译： 氰基，硝基，（C1-C3）烷基，（C1-C3）烷氧基，三氟甲基，（C1-C3）烷氧基， 三氟甲氧基，苄氧基，（C3-C6）环烷基-O-或（C3-C6）环烷基（C1-C3）烷氧基; R 2表示通式CHR 3 CONHR 4的基团，其中R 3表示氢原子或甲基，R 4表示氢原子或（C 1 -C 3）烷基，（C 3 -C 5）环烷基或（吡啶-4-基）甲基 组; 或2,2,2-三氟乙基; 或（咪唑-2-基）甲基; 或（苯并咪唑-2-基）甲基; 或任选被一个或多个卤素原子取代的苯基或氰基，硝基，（C 1 -C 3）烷基，（C 1 -C 3）烷氧基，三氟甲基或三氟甲氧基; n表示1〜3的数; 以碱的形式，与酸的加成盐，水合物或溶剂合物的形式。 还公开并要求保护的是由其衍生的药物组合物及其治疗各种疾病的治疗用途。