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公开(公告)号:US10562872B2
公开(公告)日:2020-02-18
申请号:US16072596
申请日:2017-02-06
申请人: H. Lundbeck A/S
IPC分类号: C07D295/096 , C07D333/70 , C07D491/113 , C07D295/073 , C07C209/10 , C07D265/30 , C07D295/033 , C07D413/10 , C07C211/52
摘要: The invention relates to a method for synthesis of 1-[2-(2,4-Dimethyl-phenylsulfanyl)-phenyl]piperazine in the presence of a strong base.
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公开(公告)号:US10287260B2
公开(公告)日:2019-05-14
申请号:US14780616
申请日:2014-03-28
IPC分类号: B01J23/44 , B01J23/46 , B01J23/52 , B01J23/75 , B01J31/06 , B01J31/16 , B01J31/28 , B01J35/00 , B82Y30/00 , C07B37/04 , B01J23/745 , B01J23/755 , C07D295/023 , C07D295/033
摘要: Provided is a material that, when compared with SAPd, exhibits the similar activity in cross-coupling (CC) reactions, can decrease the amount of catalytic metal that is mixed into the reaction product, and increases the number of times use can be repeated. Provided are a catalyst and a catalyst precursor that use a catalytic metal other than Pd and that exhibit the CC reaction activity similar to when Pd is used. Provided are a catalyst and a catalyst precursor that exhibit the similar CC reaction activity when using Pd or a catalytic metal other than Pd, without using a carrier such as metal and without using piranha solution. A composite wherein catalytic metal nanoparticles are dispersed in a continuous phase comprising a polymer having C2-6 alkylene group units and phenylene group units (an alkylene group unit being bonded to at least the first and fourth position of the phenylene group unit). The particle diameter of the catalytic metal nanoparticles is at most 20 nm. A composite structure including a substrate, and the aforementioned composite provided to the surface of the substrate. A method for manufacturing the composite structure by dehydrocondensating, in the presence of a catalytic metal compound, a benzene compound having at least two alkyl groups (two of the alkyl groups being at the first and fourth position) in order to form the composite on the substrate surface.
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公开(公告)号:US20190040048A1
公开(公告)日:2019-02-07
申请号:US15764616
申请日:2016-09-30
发明人: Alfonso PÉREZ ENCABO , José Ángel TURIEL HERNANDEZ , Yolanda FERNÁNDEZ SAINZ , Antonio LORENTE BONDE-LARSEN
IPC分类号: C07D409/04 , C07D215/227 , C07D295/15 , C07D295/033 , C07D409/12
摘要: A process for preparing compounds of formula (I), or a salt or solvate thereof, including Brexpiprazole, which process comprises cyclization of a compound of formula (II) or (III), or a salt or solvate thereof. The invention also refers to intermediates of said process.
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公开(公告)号:US20180127389A1
公开(公告)日:2018-05-10
申请号:US15624417
申请日:2017-06-15
申请人: H. Lundbeck A/S
发明人: Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号: C07D295/145 , C07D295/033 , C07D211/20 , C07D243/08 , C07D211/70 , C07D295/096
CPC分类号: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
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公开(公告)号:US09567307B2
公开(公告)日:2017-02-14
申请号:US13978384
申请日:2012-01-06
IPC分类号: C07D263/38 , C07D295/033 , C07D295/073 , C07D295/096 , C07D209/08 , C07D211/06 , C07F7/10 , C07B37/04 , C07C209/66 , C07C269/06 , C07C303/34 , C07D209/88 , C07D213/74 , C07D263/20
CPC分类号: C07D263/38 , C07B37/04 , C07C209/66 , C07C269/06 , C07C303/34 , C07D209/08 , C07D209/88 , C07D211/06 , C07D213/74 , C07D263/20 , C07D295/033 , C07D295/073 , C07D295/096 , C07F7/10 , C07C211/52 , C07C211/55 , C07C307/02 , C07C271/44
摘要: Embodiments of the invention provide methods and materials for chemical cross-coupling reactions that utilize aryl alcohol derivatives as cross-coupling partners. Embodiments of the invention include methods for the amination of aryl sulfamates and carbamates, which are attractive cross-coupling partners, particularly for use in multistep synthesis. Illustrative embodiments include versatile means to use simple derivatives of phenol as precursors to polysubstituted aryl amines, as exemplified by a concise synthesis of the antibacterial drug linezolid.
摘要翻译: 本发明的实施方案提供了利用芳基醇衍生物作为交联偶联物的化学交叉偶联反应的方法和材料。 本发明的实施方案包括氨基磺酸芳基酯和氨基甲酸酯的胺化方法,其是有吸引力的交联剂,特别是用于多步合成。 说明性实施方案包括使用苯酚的简单衍生物作为多取代芳基胺的前体的通用方法,例如通过抗菌药物利奈唑胺的简明合成。
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公开(公告)号:US09453009B2
公开(公告)日:2016-09-27
申请号:US14566244
申请日:2014-12-10
发明人: Julie F. Liu , Xuejun Tang , Scott L. Harbeson , Craig E. Masse
IPC分类号: C07D413/10 , C07D295/135 , C07D295/033 , C07C215/12 , C07D295/02 , C07D295/06 , C07D295/12 , C07D413/14 , C07D263/06 , A61K31/5377 , A61K45/06
CPC分类号: C07D413/10 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C215/12 , C07D263/06 , C07D295/02 , C07D295/033 , C07D295/06 , C07D295/12 , C07D295/135 , C07D413/14
摘要: The present invention is directed to a process for preparing a 2,26,6-d4-morpholine derivative represented by Structural Formula (I): or a salt thereof.
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公开(公告)号:US20160137620A1
公开(公告)日:2016-05-19
申请号:US14744197
申请日:2015-06-19
申请人: H. Lundbeck A/S
发明人: Thomas Ruhland , Garrick Paul Smith , Benny Bang-Andersen , Ask Puschl , Ejner Knud Moltzen , Kim Andersen
IPC分类号: C07D295/145 , C07D295/033
CPC分类号: C07D295/145 , C07D211/20 , C07D211/70 , C07D243/08 , C07D295/033 , C07D295/096
摘要: The invention provides compounds represented by the general formula I wherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.
摘要翻译: 本发明提供由通式I表示的化合物,其中取代基在本申请中定义。 这些化合物可用于治疗情感障碍,包括抑郁症,焦虑症,包括一般焦虑症,惊恐障碍和强迫症。
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公开(公告)号:US09061963B2
公开(公告)日:2015-06-23
申请号:US14111217
申请日:2012-04-03
申请人: Manfred Reetz , Gerlinde Mehler
发明人: Manfred Reetz , Gerlinde Mehler
IPC分类号: C07D215/38 , C07D217/22 , C07D295/033 , C07D213/74 , C07C209/10 , C07B43/04
CPC分类号: C07C209/10 , C07B43/04 , C07D213/74 , C07D215/38 , C07D217/22 , C07D295/033
摘要: A process is described for preparing aromatic and heteroaromatic amines of the general formula (I) Ar—NR1R2, in which an aromatic compound with the general formula (II) Ar—X is reacted in the presence of a catalyst with an amine of the general formula (III) H—NR1R2 and a base, wherein the catalyst is selected from transition metal complexes having one or more ligands with the general formula (IV).
摘要翻译: 描述了用于制备通式(I)Ar-NR1R2的芳族和杂芳族胺的方法,其中通式(II)Ar-X的芳族化合物在催化剂存在下与一般的胺反应 式(III)H-NR1R2和碱,其中催化剂选自具有一个或多个具有通式(IV)的配体的过渡金属配合物。
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公开(公告)号:US20150099714A1
公开(公告)日:2015-04-09
申请号:US14566244
申请日:2014-12-10
发明人: Julie F. Liu , Xuejun Tang , Scott L. Harbeson , Craig E. Masse
IPC分类号: C07D413/10 , A61K45/06 , C07D295/135 , A61K31/5377 , C07C215/12 , C07D295/033
CPC分类号: C07D413/10 , A61K31/5377 , A61K45/06 , C07B2200/05 , C07C215/12 , C07D263/06 , C07D295/02 , C07D295/033 , C07D295/06 , C07D295/12 , C07D295/135 , C07D413/14
摘要: The present invention is directed to a process for preparing a 2,26,6-d4-morpholine derivative represented by Structural Formula (I): or a salt thereof.
摘要翻译: 本发明涉及一种制备由结构式(I)表示的2,26,6-d4-吗啉衍生物或其盐的方法。
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公开(公告)号:US20140371446A1
公开(公告)日:2014-12-18
申请号:US14467625
申请日:2014-08-25
申请人: AbbVie Inc.
发明人: Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC分类号: C07F9/6571 , C07F9/6584 , C07C41/09 , C07C315/04 , C07C273/18 , C07C1/30 , C07D209/34 , C07F5/02 , C07C15/14 , C07D295/033 , C07C319/18 , C07F9/40 , C07F9/6568 , C07C201/10
CPC分类号: C07F9/657163 , B01J31/189 , B01J31/2423 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/344 , B01J2231/4227 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/30 , C07C1/321 , C07C15/14 , C07C17/093 , C07C17/361 , C07C41/09 , C07C45/68 , C07C201/10 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/40 , C07C315/04 , C07C319/14 , C07C319/18 , C07C2523/42 , C07C2523/44 , C07C2523/46 , C07C2523/52 , C07C2523/72 , C07C2523/75 , C07C2523/755 , C07C2527/14 , C07C2531/22 , C07C2531/24 , C07D209/34 , C07D239/54 , C07D295/033 , C07F5/027 , C07F9/40 , C07F9/65031 , C07F9/65515 , C07F9/6552 , C07F9/65683 , C07F9/6571 , C07F9/6584 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784 , C07C25/18
摘要: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.
摘要翻译: 本公开涉及:(a)磷酸基配体; (b)在成键反应中使用这种磷酸基配体的方法; 和(c)制备磷酸基配体的方法。
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