公开(公告)号：US20200093814A1

公开(公告)日：2020-03-26

申请号：US16471677

申请日：2017-12-21

申请人： AiCuris GmbH & Co. KG

发明人： Irith WIEGAND ,  Cuong VUONG ,  Daniela M. RAUSCH

IPC分类号： A61K31/454 ,  A61K31/427 ,  A61K45/06 ,  A61K31/424 ,  A61K31/431 ,  A61K31/43 ,  A61P31/04

摘要： This invention relates to β-lactam compounds in combination with further drugs, e.g. β-lactamase inhibitors (BLIs), for use in the treatment and prophylaxis of infections caused by resistant bacteria.

公开(公告)号：US20170100379A1

公开(公告)日：2017-04-13

申请号：US15382986

申请日：2016-12-19

申请人： AiCuris GmbH & Co. KG

发明人： Burkhard KLENKE ,  Irith WIEGAND ,  Guido SCHIFFER ,  Heike BROETZ-OESTERHELT ,  Samarendra N. MAITI ,  Jehangir KHAN ,  Andhe REDDY ,  Zhixiang YANG ,  Mostafa HENA ,  Guofeng JIA ,  Ou LIGONG ,  Hong LIANG ,  Judy YIP ,  Chuanjun GAO ,  Sabiha TAJAMMUL ,  Rahim MOHAMMAD ,  Ganguli BISWAJEET

IPC分类号： A61K31/427 ,  A61K31/454 ,  A61K31/501 ,  A61K45/06 ,  A61K31/433 ,  A61K31/496 ,  A61K31/506 ,  A61K31/4439 ,  A61K31/497

CPC分类号： A61K31/427 ,  A61K31/4178 ,  A61K31/433 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K45/06 ,  C07D417/12 ,  C07D417/14 ,  Y02A50/473 ,  Y02A50/475 ,  Y02A50/478 ,  Y02A50/481

摘要： The present invention relates to novel β-lactam compounds, their preparation and use. In particular, this invention relates to novel β-lactam compounds which are amidine substituted monobactam derivatives useful as antimicrobial agents and their preparation.