公开(公告)号：US20080054514A1

公开(公告)日：2008-03-06

申请号：US11851117

申请日：2007-09-06

申请人： Akifumi KATO ,  Hidekazu YAMAZAKI ,  Hitoshi IKEDA

发明人： Akifumi KATO ,  Hidekazu YAMAZAKI ,  Hitoshi IKEDA

IPC分类号： B29C39/20

CPC分类号： B29C41/26 ,  B29C48/08 ,  B29C48/91 ,  B29C48/914 ,  B29C48/915 ,  B29C48/9165 ,  B29K2001/00 ,  B29K2001/12

摘要： A polymer film producing apparatus includes a casting device, having a casting die, for ejecting dope to form a bead, and casting the bead on a support drum traveling continuously to form a cast film, the dope containing polymer, solvent and additive. A dryer dries the cast film stripped from the support drum, to obtain a polymer film. A voltage application device is connected with the support drum, for applying voltage to the support drum during casting of the casting device. Preferably, the support drum is electrically non-grounded, and has a surface coated with an electrical insulation film. A surface potential V of the support drum is in a range of 0.1 kV

摘要翻译： 聚合物膜制造装置包括铸造装置，具有用于喷射涂料以形成珠粒的流延模具，并且在连续行进的载体鼓上浇铸珠以形成流延膜，所述涂料含有聚合物，溶剂和添加剂。 干燥器干燥从支撑鼓剥离的流延膜，以获得聚合物膜。 电压施加装置与支撑鼓连接，用于在铸造装置的铸造期间向支撑鼓施加电压。 优选地，支撑滚筒是非接地的，并且具有涂覆有电绝缘膜的表面。 支撑鼓的表面电位V在0.1kV <| V | <3kV的范围内。 减压室靠近支撑滚筒的表面设置，用于紧固支撑滚筒表面上的滚珠的接触。

公开(公告)号：US20100162418A1

公开(公告)日：2010-06-24

申请号：US12540501

申请日：2009-08-13

申请人： Yutaka KANDA ,  Hiroshi SATO ,  Tsuyoshi YAMADA ,  Akifumi KATO ,  Mitsuo SATOH

发明人： Yutaka KANDA ,  Hiroshi SATO ,  Tsuyoshi YAMADA ,  Akifumi KATO ,  Mitsuo SATOH

IPC分类号： A61K38/17 ,  C07K14/47 ,  A61P29/00 ,  A61P31/04 ,  A61P7/02 ,  C12N5/10 ,  A01K67/027 ,  C12P21/00

CPC分类号： C07K14/745 ,  A61K38/00 ,  C12P21/005

摘要： A pharmaceutical agent for treating a disease such as inflammatory diseases, blood coagulation diseases associated with deficiency of Protein S has been required. The present invention provides a Protein S composition comprising recombinant Protein S molecules having complex type N-glycoside-linked sugar chains, wherein the Protein S has a higher binding activity to a receptor for advanced glycation end products (hereinafter referred to as “RAGE”) than native Protein S present in healthy human blood, and also has a higher ratio of sugar chains in which fucose is not bound to the complex type N-glycoside-linked sugar chains bound to Protein S than native Protein S present in healthy human blood.

摘要翻译： 需要用于治疗诸如炎性疾病，与蛋白S缺乏相关的血液凝固疾病等疾病的药剂。 本发明提供了包含具有复合型N-糖苷连接的糖链的重组蛋白S分子的蛋白S组合物，其中蛋白S与晚期糖基化终产物的受体（以下称为“RAGE”）具有较高的结合活性， 比存在于健康人血液中的天然蛋白S高，并且与健康人血液中存在的天然蛋白S相比，岩藻糖与其与蛋白S结合的复合型N-糖苷连接的糖链不结合的糖链的比例更高。