公开(公告)号：US10342968B2

公开(公告)日：2019-07-09

申请号：US13995720

申请日：2011-12-21

申请人： Akihiro Hasui ,  Atsuhiko Shiraishi ,  Ken-ichi Hattori ,  Shinji Tanaka ,  Hirokazu Takahashi ,  Makoto Takahashi

发明人： Akihiro Hasui ,  Atsuhiko Shiraishi ,  Ken-ichi Hattori ,  Shinji Tanaka ,  Hirokazu Takahashi ,  Makoto Takahashi

IPC分类号： A61N1/04 ,  A61N1/32 ,  A61N1/30 ,  A61M37/00

摘要： The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.

公开(公告)号：US20130310733A1

公开(公告)日：2013-11-21

申请号：US13995720

申请日：2011-12-21

申请人： Akihiro Hasui ,  Atsuhiko Shiraishi ,  Ken-ichi Hattori ,  Shinji Tanaka ,  Hirokazu Takahashi ,  Makoto Takahashi

发明人： Akihiro Hasui ,  Atsuhiko Shiraishi ,  Ken-ichi Hattori ,  Shinji Tanaka ,  Hirokazu Takahashi ,  Makoto Takahashi

IPC分类号： A61N1/04

CPC分类号： A61N1/0448 ,  A61M2037/0007 ,  A61N1/0428 ,  A61N1/30 ,  A61N1/325

摘要： The present invention verifies a method of reducing skin irritation (particularly, cumulative skin irritation) caused by transdermal administration of a local anesthetic using iontophoresis, and provides an electrode pad for relief from a puncture pain which is safe not only at single administration but also at repeated administrations. The electrode pad comprises a base sheet; an electrode placed on the base sheet; an adhesive sheet placed on the base sheet and having an opening, within which the electrode being exposed; and a medicament reservoir containing a local anesthetic and placed in the opening of the adhesive sheet while being in contact with the electrode. An inner peripheral surface of the opening of the adhesive sheet and an outer peripheral surface of the medicament reservoir are prevented from coming into contact with human skin while contacting with each other, and thereby skin irritation is reduced.

摘要翻译： 本发明验证了使用离子渗透电泳法减少透皮给药局部麻醉剂引起的皮肤刺激（特别是累积性皮肤刺激）的方法，并且提供了用于缓解穿刺疼痛的电极垫，其不仅在单次给药时也是安全的， 重复行政。 电极垫包括基片; 放置在基片上的电极; 粘合片放置在基片上并具有开口，电极被露出; 以及含有局部麻醉剂并放置在与电极接触的粘合片的开口中的药物容器。 防止粘合片的开口的内周面和药剂容器的外周面与人的皮肤接触，同时彼此接触，从而减少皮肤刺激。

公开(公告)号：US06586022B2

公开(公告)日：2003-07-01

申请号：US09924539

申请日：2001-08-09

申请人： Mitsuhiro Kawada ,  Ken-ichi Hattori ,  Shunji Aono

发明人： Mitsuhiro Kawada ,  Ken-ichi Hattori ,  Shunji Aono

IPC分类号： A61K3578

CPC分类号： A61K36/65 ,  A61K2300/00

摘要： An ulcerative colitis treating therapeutic agent which is very effective in repairing damaged tissues of ulcerative colitis and yet has no need of fear of side effects as those of steroids is provided. It is an therapeutic agent for treating ulcerative colitis which has peony root, especially, dry powders of peony root, or a Chinese medicine formulation containing peony root as an active ingredient. It is also an therapeutic agent for treating ulcerative colitis which has, as an active ingredient, an infused dry extract of peony root, an infused dry extract of a Chinese medicine formulation containing peony root, or especially an infused dry extract of Jia-Wei-Xiao-Yao-San, Dang-Gui-Shao-Yao-San, Shao-Yao-Gan-Cao-Tang, or Gui-Zhi-Fu-Ling-Wan.