摘要:
A door module panel is initially mounted with a door harness and is provided with a panel hole at a position where a descending window glass does not interfere. The door harness is wired from a first surface facing a passenger compartment of the door module panel to a second surface facing a door frame through the panel hole. The door module panel has a side face, from a middle portion of which a protruding member is extended and bent towards the door frame. The protruding member includes a harness hole, through which is passed the door harness extending from the second surface of the door module panel. The door harness is then fitted into the harness hole with a grommet. The door frame is provided with a side panel notched with a groove. When the door module panel is incorporated into the door frame, the protruding member fits into the notched groove on the same plane. The door harness thus can be installed very easily.
摘要:
A DNA, which encodes the following polypeptide (a), (b), (c) or (d): (a) a polypeptide consisting of an amino acid sequence represented by SEQ ID NO: 2 or 4, (b) a polypeptide consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 or 4 by deletion, substitution or addition of one or several amino acids, and having hypophosphatemia-inducing activity, phosphate transport-suppressing activity, calcification-suppressing activity or in vivo vitamin D metabolism-regulating activity, (c) a polypeptide consisting of a partial sequence of the amino acid sequence represented by SEQ ID NO: 2, wherein the above partial sequence contains an amino acid sequence at least ranging from the 34th to 201st amino acids in the above amino acid sequence, or (d) a polypeptide consisting of a partial sequence of the amino acid sequence represented by SEQ ID NO: 2, wherein the above partial sequence: (i) contains an amino acid sequence ranging from at least the 34th to 201st amino acids in said amino acid sequence, (ii) consists of an amino acid sequence derived from the partial sequence by deletion, substitution, or addition of one or several amino acids, and (iii) has hypophosphatemia-inducing activity, phosphate transport-suppressing activity, calcification-suppressing activity or in vivo vitamin D metabolism-regulating activity.
摘要翻译:编码以下多肽(a),(b),(c)或(d)的DNA:(a)由SEQ ID NO:2或4所示的氨基酸序列组成的多肽,(b) 由SEQ ID NO:2或4表示的氨基酸序列衍生的氨基酸序列,通过缺失,取代或添加一个或几个氨基酸,并具有低磷酸血症诱导活性,磷酸盐转运抑制活性,钙化抑制 活性或体内维生素D代谢调节活性,(c)由SEQ ID NO:2表示的氨基酸序列的部分序列组成的多肽,其中上述部分序列含有至少在第34位的氨基酸序列 至(d)由SEQ ID NO:2表示的氨基酸序列的部分序列组成的多肽,其中上述部分序列:(i)含有氨基酸序列, 从至少34t h至所述氨基酸序列中的第201位氨基酸,(ii)由部分序列衍生的氨基酸序列由一个或几个氨基酸的缺失,取代或添加组成,和(iii)具有低磷酸血症诱导活性,磷酸 运输抑制活性,钙化抑制活性或体内维生素D代谢调节活性。
摘要:
A method for treating a hypophosphatemic bone disease, such as X-linked hypophosphatemia (XLH). The method entails administering to a subject a pharmaceutical composition, which contains an antibody that binds to an FGF-23 polypeptide and a pharmaceutically acceptable carrier.