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公开(公告)号:US08426588B2
公开(公告)日:2013-04-23
申请号:US13524318
申请日:2012-06-15
申请人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号: C07D253/08
CPC分类号: C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译: 指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗活性。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号:US20120253041A1
公开(公告)日:2012-10-04
申请号:US13524318
申请日:2012-06-15
申请人: Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人: Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号: C07D253/08
CPC分类号: C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译: 指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号:US20060223836A1
公开(公告)日:2006-10-05
申请号:US11442141
申请日:2006-05-30
申请人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号: A61K31/517 , C07D239/96
CPC分类号: C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
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公开(公告)号:US07605165B2
公开(公告)日:2009-10-20
申请号:US10921929
申请日:2004-08-20
申请人: Kazuyuki Sagi , Hiroyuki Izawa , Akira Chiba , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuji Tanaka , Miho Ono , Masahiro Murata
发明人: Kazuyuki Sagi , Hiroyuki Izawa , Akira Chiba , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuji Tanaka , Miho Ono , Masahiro Murata
IPC分类号: A61K31/517 , C07D239/88 , C07D239/96
CPC分类号: C07D265/26 , C07D239/54 , C07D239/80 , C07D239/96 , C07D253/04 , C07D285/16 , C07D285/24 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to α4 integrin and therapeutic agents for various diseases concerning α4 integrin.
摘要翻译: 本发明涉及对α4整联蛋白具有拮抗作用的以下苯丙氨酸衍生物或其类似物,以及涉及α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号:US07193108B2
公开(公告)日:2007-03-20
申请号:US10763237
申请日:2004-01-26
申请人: Akira Chiba , Kazuyuki Sagi , Toshihiko Yoshimura , Tatsuya Okuzumi , Hiroyuki Izawa , Masahiro Murata
发明人: Akira Chiba , Kazuyuki Sagi , Toshihiko Yoshimura , Tatsuya Okuzumi , Hiroyuki Izawa , Masahiro Murata
IPC分类号: C07C315/00 , C07C317/00 , C07C229/00 , A61K31/00
CPC分类号: A61K31/517 , A61K31/235 , C07C275/42 , C07D239/96
摘要: Specified phenylpropionic acid derivatives and analogues thereof have an antagonistic activity to α 4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α 4 integrin, such as inflammatory diseases in which α 4 integrin-depending adhesion process participates in the pathology, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.
摘要翻译: 指定的苯丙酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂或预防剂,例如其中α4整联蛋白依赖性粘附过程参与病理学,类风湿性关节炎,炎性肠病,系统性红斑狼疮,多发性硬化症,Sjögren's 综合征,哮喘,牛皮癣,过敏,糖尿病,心血管疾病,动脉硬化,再狭窄,肿瘤增殖,肿瘤转移和移植排斥。
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公开(公告)号:US07153963B2
公开(公告)日:2006-12-26
申请号:US10300856
申请日:2002-11-21
申请人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号: C07D239/72 , A61K31/517
CPC分类号: C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin
摘要翻译: 指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂
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公开(公告)号:US20050101779A1
公开(公告)日:2005-05-12
申请号:US10921929
申请日:2004-08-20
申请人: Kazuyuki Sagi , Hiroyuki Izawa , Akira Chiba , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuji Tanaka , Miho Ono , Masahiro Murata
发明人: Kazuyuki Sagi , Hiroyuki Izawa , Akira Chiba , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuji Tanaka , Miho Ono , Masahiro Murata
IPC分类号: A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/06 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/04 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D217/22 , C07D239/54 , C07D239/72 , C07D239/80 , C07D239/96 , C07D241/04 , C07D253/04 , C07D265/26 , C07D285/16 , C07D285/24 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04
CPC分类号: C07D265/26 , C07D239/54 , C07D239/80 , C07D239/96 , C07D253/04 , C07D285/16 , C07D285/24 , C07D403/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: The present invention relates to the following phenylalanine derivatives or analogues thereof having an antagonistic activity to α4 integrin and therapeutic agents for various diseases concerning α4 integrin.
摘要翻译: 本发明涉及对α4整联蛋白具有拮抗作用的以下苯丙氨酸衍生物或其类似物,以及涉及α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号:US08222405B2
公开(公告)日:2012-07-17
申请号:US12951180
申请日:2010-11-22
申请人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号: C07D285/24 , C07D239/72 , C07D403/04 , C07D253/08 , C07D265/26 , C07D487/04
CPC分类号: C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译: 指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号:US20110065918A1
公开(公告)日:2011-03-17
申请号:US12951180
申请日:2010-11-22
申请人: Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人: Shingo MAKINO , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号: C07D285/24 , C07D239/72 , C07D403/04 , C07D253/08 , C07D265/26 , C07D487/04 , C07D239/54
CPC分类号: C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译: 指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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公开(公告)号:US07872125B2
公开(公告)日:2011-01-18
申请号:US11442141
申请日:2006-05-30
申请人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
发明人: Shingo Makino , Tatsuya Okuzumi , Toshihiko Yoshimura , Yuko Satake , Nobuyasu Suzuki , Hiroyuki Izawa , Kazuyuki Sagi , Akira Chiba , Eiji Nakanishi , Masahiro Murata , Takashi Tsuji
IPC分类号: A61K31/517 , C07D239/96
CPC分类号: C07D239/22 , C07D239/54 , C07D239/78 , C07D239/80 , C07D239/91 , C07D239/95 , C07D239/96 , C07D253/08 , C07D265/26 , C07D285/16 , C07D285/24 , C07D401/12 , C07D471/04 , C07D475/02 , C07D487/04 , Y02P20/582
摘要: Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
摘要翻译: 指定的苯丙氨酸衍生物及其类似物对α4整联蛋白具有拮抗作用。 它们被用作关于α4整联蛋白的各种疾病的治疗剂。
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