Modified polyvinyl alcohol
    1.
    发明授权
    Modified polyvinyl alcohol 失效
    改性聚乙烯醇

    公开(公告)号:US5783628A

    公开(公告)日:1998-07-21

    申请号:US612434

    申请日:1996-03-07

    IPC分类号: B01F17/00 B01F17/52 C08F8/00

    CPC分类号: B01F17/0028 C08F8/00 C08F8/44

    摘要: A modified polyvinyl alcohol is disclosed, which comprises the following structural units (I) and (II) and has a weight average molecular weight of from 3,000 to 400,000: ##STR1## wherein R.sup.1 represents H or CH.sub.3 ; and M.sup.1 represents H, an alkali metal, ammonium, alkylammonium, or alkanolammonium. The modified polyvinyl alcohol may be sulfonated. The modified polyvinyl alcohol is used as a dispersant such as a drilling fluid additive.

    摘要翻译: 公开了一种改性的聚乙烯醇,其包含以下结构单元(I)和(II),其重均分子量为3,000至400,000:(I)其中R 1表示H或 CH3; M1表示H,碱金属,铵,烷基铵或烷醇铵。 改性的聚乙烯醇可以被磺化。 改性聚乙烯醇用作分散剂如钻井液添加剂。

    Brake pad wear detecting apparatus

    公开(公告)号:US06478119B2

    公开(公告)日:2002-11-12

    申请号:US09985944

    申请日:2001-11-06

    IPC分类号: F16D6600

    摘要: A probe case attached to a back plate includes a first elastic locking piece for coupling with the back plate and a second elastic locking piece for fixedly positioning a probe. When the first elastic locking piece is attached to the back plate in a state of not mounting the probe, the first elastic locking piece is brought into a tacked state of being coupled to the back plate attachably and detachably. Further, when the probe is mounted in the tacked state, elastic deformation of the first elastic locking piece is restricted by the probe to thereby bring about a locking state in which the probe case cannot be detached from the back plate. The second elastic locking piece includes a release operating portion for causing elastic deformation for disengaging engagement with the probe.

    GPIb-lipid bond construct and use thereof
    3.
    发明授权
    GPIb-lipid bond construct and use thereof 失效
    GPIb-脂质结合构型及其用途

    公开(公告)号:US06926884B2

    公开(公告)日:2005-08-09

    申请号:US10220610

    申请日:2001-03-02

    摘要: The present invention provides a conjugate wherein GP (glycoprotein) Ib and a lipid are bonded via polyalkylene oxide. The present invention also provides a complex (GPIb lipid complex) containing this conjugate and a free lipid. The GPIb lipid complex is expected to have a potential for practical application in a wide range, as a platelet substitute, a pharmaceutical agent for the prophylaxis or treatment of angiopathy, vascular damage and thrombosis, a diagnostic for vWF deficiency and the like, a biological or medical reagent, a reagent for screening platelet aggregation suppressant or antithrombosis, and the like. The GPIb lipid complex of the present invention is also useful as a diagnostic for finding the location of vascular lesion or thrombus formation, or a therapeutic agent thereof. Moreover, the GPIb lipid complex of the present invention is also superior in retention property in blood, which enables continuous expression of a pharmacological action. The conjugate of the present invention is highly utilizable as an active ingredient of the GPIb lipid complex of the present invention.

    摘要翻译: 本发明提供了通过聚环氧烷键合GP(糖蛋白)1b和脂质的结合物。 本发明还提供了含有该缀合物和游离脂质的复合物(GPIb脂质复合物)。 预期GPIb脂质复合物在广泛范围内具有实际应用的潜力,作为血小板替代物,用于预防或治疗血管病,血管损伤和血栓形成的药剂,对vWF缺乏症的诊断等,生物 或医用试剂,用于筛选血小板聚集抑制剂或抗血栓形成的试剂等。 本发明的GPIb脂质复合物也可用作诊断血管损伤或血栓形成的位置,或其治疗剂。 此外,本发明的GPIb脂质复合物在血液中的保留性也优异,能够连续表达药理作用。 本发明的缀合物作为本发明的GPIb脂质复合物的活性成分是高度可利用的。

    Liquid-enclosing type vibration isolating device
    4.
    发明授权
    Liquid-enclosing type vibration isolating device 失效
    液体封闭式隔振装置

    公开(公告)号:US5971376A

    公开(公告)日:1999-10-26

    申请号:US34071

    申请日:1998-03-03

    摘要: The present invention provides a liquid-enclosing type vibration isolating device of all around stopper type with a reliable stopper action at a time of a large displacement of a main body metal fitting in the device, in a liquid-enclosing type vibration isolating device in which a main body metal fitting and a mounting metal fitting disposed thereunder are connected to each other through a vibration isolating body formed with a rubber elastic member with a liquid being sealed therewithin, the lower mounting metal fitting comprises a boss metal fitting integrally formed with a mounting bolt and inserted into the vibration isolating body, a spacer metal fitting having a flange portion for a stopper at the upper portion and fitted into the boss metal fitting, and a mounting plate metal fitting fixed to the boss metal fitting so as to hold the spacer metal fitting in a fixed state, a required clearance is provided between the flange portion of the spacer metal fitting and the plate metal fitting, and a lower end portion of a stabilizer continuously provided to the main body metal fitting is inwardly bent so as to be positional within the clearance, thereby achieving a stopper action.

    摘要翻译: 本发明提供了一种全封闭式隔离装置,在液体封闭式隔振装置中,在本体金属配件位移大的位置处具有可靠的止动作用的液体封闭式隔振装置,其中, 主体金属配件和安装在其下方的安装金属配件通过形成有橡胶弹性构件的隔振体彼此连接,橡胶弹性构件被密封在其中,下安装金属配件包括:凸台金属配件,其与安装件 螺栓并插入到隔振体中,间隔金属配件,其具有用于上部的塞子的凸缘部分并且装配到凸台金属配件中;以及安装板金属配件,固定到凸台金属配件以便保持间隔件 金属配件处于固定状态,在间隔金属配件的凸缘部分和板金属之间设置所需的间隙 连接在主体金属配件上的稳定器的下端部向内弯曲成位于间隙内,从而实现止动作用。

    Liposome preparation
    5.
    发明授权
    Liposome preparation 失效
    脂质体制备

    公开(公告)号:US5776488A

    公开(公告)日:1998-07-07

    申请号:US716201

    申请日:1996-09-10

    IPC分类号: A61K9/127 A61K9/133

    摘要: A liposome preparation comprising a water-soluble 2'-deoxy-2'methylidenecytidine compound encapsulated therein and a compound which positively charges the surface of lipid membrane. This liposome preparation is not only expected to decrease toxicity to myeloid tissue, which is caused by a water-soluble 2'-deoxycytidine compound having anti-malignant tumor activity, but also expected to accumulate the active ingredient in tumor tissues by virtue of an improved residence thereof in blood. Therefore, the preparation can maintain or enhance anti-tumor effects without causing side effects, and is useful for the treatment of malignant tumors.

    摘要翻译: PCT No.PCT / JP95 / 00383 Sec。 371日期:1996年9月10日 102(e)1996年9月10日PCT PCT 1995年3月8日PCT公布。 第WO95 / 24201号公报 日期1995年9月14日包含其中包封的水溶性2'-脱氧-2'-亚甲基内酯化合物的脂质体制剂和对脂质膜表面带正电的化合物。 该脂质体制剂不仅预期会降低对具有抗恶性肿瘤活性的水溶性2'-脱氧胞苷化合物引起的骨髓组织的毒性,而且还预期通过改善的肿瘤组织积累活性成分 居住在血液中。 因此,该制剂可以维持或增强抗肿瘤作用而不引起副作用,并且可用于治疗恶性肿瘤。

    Solid electrolytic capacitor and production method thereof, and conductive polymer polymerizing oxidizing agent solution

    公开(公告)号:US06519137B1

    公开(公告)日:2003-02-11

    申请号:US09807760

    申请日:2001-07-16

    IPC分类号: H01G902

    CPC分类号: H01G9/025 H01G9/15 Y10T29/417

    摘要: The present invention relates to a solid electrolytic capacitor having a large capacitance and a higher resistance to heat and adapted as a surface-mount device and a method of producing the same. The invention may include the followings features: (1) a layer containing an electroconductive polymer and a less conductive polymer is provided on a dielectric oxide film on the positive electrode foil; (2) a separator of a polyester resin based unwoven fabric made by span bonding and/or wet processing a resin material is sandwiched between the positive electrode foil and the negative electrode foil and rolled together to form a capacitor element which also include a solid electrolyte; (3) a separator is sandwiched between the positive electrode foil and the negative electrode foil coated with a dielectric oxide film exhibiting a withstand voltage of 0.8 to 10 V and rolled together to form a capacitor element which also include a solid electrolyte of an electrically conductive polymer; (4) the negative electrode foil is coated with a layer made of at least a metallic material selected from titanium, zirconium, hafnium, and its compound or of a carbon material; (5) the capacitor element has its content of, water adjusted to not higher than 1% by weight and is enclosed in an outer case; (6-A) the solid electrolyte is a conductive polymer prepared by chemically polymerizing a heterocyclic monomer with the use of an oxidizing solution of which the weight ratio of bivalent iron to trivalent iron is not higher than 0.02; (6-B) the solid electrolyte is a conductive polymer prepared by chemically polymerizing a heterocyclic monomer with the use of an oxidizing solution of which the molar ratio of aliphatic and/or aromatic sulfonic acid to trivalent iron ranges from 3.0 to 3.5; and (7) the solid electrolyte is a conductive polymer prepared by chemically polymerizing a heterocyclic monomer in which the remaining of a basic organic solvent is not higher than 0.8%.