公开(公告)号：US07884243B2

公开(公告)日：2011-02-08

申请号：US10583902

申请日：2004-12-22

申请人： Alain Burgos ,  Blandine Bertrand ,  Sonia Roussiasse ,  Jean-François Pluvie ,  Sylvie Blanchet ,  Juliette Martin ,  Florence Perrin ,  Françoise Bourdeau

发明人： Alain Burgos ,  Blandine Bertrand ,  Sonia Roussiasse ,  Jean-François Pluvie ,  Sylvie Blanchet ,  Juliette Martin ,  Florence Perrin ,  Françoise Bourdeau

IPC分类号： C07C233/00

CPC分类号： C07C231/10 ,  C07C233/06 ,  C07C2602/08 ,  C07C2602/10

摘要： A process for the production of ene-amide derivatives represented by the formula (I) wherein R1 and R2 and R3 are independently a hydrogen atom, an alkyl, a cycloalkyl, a cycloalkylalkyl, an alkylaryl, an aryl, a heterocycle, a cyano, an alkoxy, an aryloxy, a carboxyl, a carbamoyl, —CONR5R6 (in which R5 and R6 are independently an alkyl, arylalkyl or aryl group said ring being substituted or not with a functional group or with R5) or —COOR5 group (in which R5 is an alkyl, alkylaryl or aryl group), said alkyl, cycloalkyl, cycloalkylalkyl, alkylaryl and aryl groups being substituted or not with a functional group or with R5; or R1 and R2 taken together, may form a ring (which terms includes mono-, di- and higher polycyclic ring systems); R4 is a hydrogen atom, an alkyl, an aryl, an alkylaryl, said groups are substituted or not with a halogen atom as Cl, Br, or F; X is an oxygen atom or a leaving group and m is an integer 1 or 2; when m is 1 then X is a leaving group; when m is 2 then X is a oxygen atom, which comprise: a hydrogenation/isomerization reaction in presence of a heterogeneous catalyst, of an oxime derivatives of formula (II) wherein R1, R2 and R3 are as defined above with an acyl derivative of formula (III) (R4CO)mX wherein R4, m and X are as defined above.

摘要翻译： 制备由式（I）表示的烯 - 酰胺衍生物的方法，其中R 1和R 2和R 3独立地为氢原子，烷基，环烷基，环烷基烷基，烷基芳基，芳基，杂环，氰基， 烷氧基，芳氧基，羧基，氨基甲酰基-CONR 5 R 6（其中R 5和R 6独立地是烷基，芳基烷基或芳基，所述环被取代或不被官能团或与R5）或-COOR5基团（其中 R5是烷基，烷基芳基或芳基），所述烷基，环烷基，环烷基烷基，烷基芳基和芳基被官能团取代或不与R5取代; 或R 1和R 2一起形成环（该术语包括单环，二和更高多环系）; R4是氢原子，烷基，芳基，烷基芳基，所述基团被卤素原子取代或未被取代为Cl，Br或F; X是氧原子或离去基团，m是整数1或2; 当m为1时，X为离去基团; 当m为2时，X为氧原子，其包括：在非均相催化剂存在下的氢化/异构化反应，式（II）的肟衍生物，其中R 1，R 2和R 3如上定义，与酰基衍生物 式（III）（R4CO）mX其中R4，m和X如上所定义。