公开(公告)号：US20140100371A1

公开(公告)日：2014-04-10

申请号：US13885059

申请日：2011-11-18

申请人： Alain Cotte ,  Matthias Cotta ,  Felix Rudolph ,  Bingrui Song ,  Lukas Goossen

发明人： Alain Cotte ,  Matthias Cotta ,  Felix Rudolph ,  Bingrui Song ,  Lukas Goossen

IPC分类号： C07D333/22 ,  C07C253/00 ,  C07D307/52 ,  C07C45/42 ,  C07C249/02 ,  C07D213/53

CPC分类号： C07C253/00 ,  C07C45/42 ,  C07C249/02 ,  C07C253/30 ,  C07C319/20 ,  C07C2601/14 ,  C07C2603/26 ,  C07D213/53 ,  C07D307/52 ,  C07D333/22 ,  C07C251/18 ,  C07C251/24 ,  C07C255/61 ,  C07C323/45

摘要： A process for preparing azomethines of the general formula (V) where R is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, and R1 is an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms, R2 is hydrogen or an optionally substituted carbocyclic aromatic radical having 6 to 24 carbon atoms or an optionally substituted alkyl radical or an optionally substituted cycloalkyl radical N or an optionally substituted heteroaromatic radical having 5 to 24 carbon atoms by reacting alpha-oxo carboxylates of the general formula (I) where n is a number in the range from 1 to 6, M(n+) is a cation, with aryl bromides of the general formula (IV) and amines of the general formula (II) via the alpha-iminocarboxylate intermediate of the general formula (III), in the presence of two transition metals or compounds thereof as catalyst, is described.

摘要翻译： 一种制备通式（Ⅴ）的偶氮甲碱的方法，其中R是具有6至24个碳原子的任选取代的碳环芳族基团或任选取代的烷基或任选取代的具有5至24个碳原子的杂芳族基团，R 1是 具有6至24个碳原子的任选取代的碳环芳族基团或具有5至24个碳原子的任选取代的杂芳族基团，R 2是氢或任选取代的具有6至24个碳原子的碳环芳族基团或任选取代的烷基或任选取代的 环烷基N或具有5至24个碳原子的任选取代的杂芳族基团，其中通式（I）的α-氧代羧酸盐，其中n是1至6的数，M（n +）是阳离子，与 通式（Ⅳ）的芳基溴和通式（Ⅱ）的胺通过一般的α-亚氨基羧酸酯中间体 式（III）在两种过渡金属或其化合物作为催化剂的存在下进行了描述。