公开(公告)号：US20240076267A1

公开(公告)日：2024-03-07

申请号：US18280388

申请日：2022-03-04

申请人： ADISSEO FRANCE S.A.S.

发明人： Virginie BELLIERE-BACA ,  Aymeric GUINAUDEAU

IPC分类号： C07C319/20 ,  C07C319/28

CPC分类号： C07C319/20 ,  C07C319/28

摘要： A method for the preparation of the 2-hydroxy-4-methylthiobutyronitrile (HMTBN) or its selenium equivalent (HMSeBN) from hydrocyanic acid and 3-methylthiopropanal (MTP) or the corresponding selenium aldehyde (MSeP) includes the following steps: the molar ratio of the HCN to MTP or to MSeP is adjusted to a value greater than or equal to 1 and the pH is adjusted and maintained at a value greater than or equal to 3.5, to obtain a reaction medium in which the HMTBN or the HMSeBN is formed, then the pH of the reaction medium is lowered to a value less than or equal to 2.5 and the HCN is extracted from the reaction medium, and the HMTBN or the HMSeBN is recovered. The applications of this method are also related.

公开(公告)号：US20240034716A1

公开(公告)日：2024-02-01

申请号：US18032872

申请日：2021-10-20

申请人： ADISSEO FRANCE S.A.S.

发明人： Félix TAULOU ,  Didier MORVAN ,  Virginie BELLIERE-BACA ,  Dorothée LAURENTI

IPC分类号： C07C319/20 ,  B01J21/06 ,  B01J27/053 ,  B01J37/20 ,  B01J21/04 ,  B01J35/10 ,  C07C391/00

CPC分类号： C07C319/20 ,  B01J21/063 ,  B01J27/053 ,  B01J37/20 ,  B01J21/04 ,  B01J21/066 ,  B01J35/1004 ,  C07C391/00

摘要： A method for preparing 2-hydroxy-4-methylthiobutyric acid (HMTBA) or 2-hydroxy-4-methylselenobutyric acid (HMSeBA) by catalytic conversion of 2-hydroxy-4-methylthiobutyronitrile or 2-hydroxy-4-methylselenobutyronitrile, respectively, where said conversion is carried out in the presence of water and at least one weak acid and one catalyst comprising at least one of alumina, titanium dioxide and zirconia.

公开(公告)号：US11882852B2

公开(公告)日：2024-01-30

申请号：US16965519

申请日：2019-01-23

申请人： HALDOR TOPSØE A/S

发明人： Søren Tolborg ,  Juan Salvador Martínez Espín ,  Esben Taarning

IPC分类号： C07C51/00 ,  C07C51/44 ,  C07C227/08 ,  C07C51/16 ,  C07C67/39 ,  C07C319/20 ,  A23K20/142 ,  B01J29/70 ,  C07C53/126 ,  C07C57/30 ,  C08G63/06 ,  C08K5/101 ,  C08K5/3417 ,  C08K5/3445

CPC分类号： A23K20/142 ,  B01J29/7049 ,  B01J29/7057 ,  C07C51/00 ,  C07C51/16 ,  C07C51/44 ,  C07C53/126 ,  C07C57/30 ,  C07C67/39 ,  C07C227/08 ,  C07C319/20 ,  C08G63/06 ,  C08K5/101 ,  C08K5/3417 ,  C08K5/3445 ,  C07C67/39 ,  C07C69/675 ,  C07C67/39 ,  C07C69/732 ,  C07C51/16 ,  C07C59/105 ,  C07C51/16 ,  C07C59/48 ,  C07C319/20 ,  C07C323/52

摘要： New process of producing alpha-hydroxy compounds from sustainable resources useful as platform chemicals, such as hydroxy analogues of amino acids or polymer precursors.

公开(公告)号：US11827586B2

公开(公告)日：2023-11-28

申请号：US17052541

申请日：2019-05-15

申请人： ASAHI KASEI KABUSHIKI KAISHA

发明人： Nobuhisa Miyake ,  Kazuhiro Takagaki ,  Tsubasa Uematsu ,  Koichi Nakaoka ,  Masaaki Shinohata

IPC分类号： C07C269/06 ,  C07C227/18 ,  C07C249/02 ,  C07C273/18 ,  C07C229/08 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C251/16 ,  C07C271/48 ,  C07C275/10

CPC分类号： C07C269/06 ,  C07C227/18 ,  C07C249/02 ,  C07C273/18 ,  C07C229/08 ,  C07C229/24 ,  C07C229/26 ,  C07C229/36 ,  C07C251/16 ,  C07C271/48 ,  C07C275/10 ,  C07C227/18 ,  C07C229/08 ,  C07C227/18 ,  C07C229/24 ,  C07C227/18 ,  C07C229/26 ,  C07C227/18 ,  C07C229/36 ,  C07C249/02 ,  C07C251/08 ,  C07C249/02 ,  C07C251/16 ,  C07C269/06 ,  C07C271/48 ,  C07C273/18 ,  C07C275/10 ,  C07C319/20 ,  C07C323/57

摘要： The present invention provides a method for producing an amino acid aminoalkyl ester or an inorganic acid salt thereof by reacting a compound represented by general formula (I) shown below or a compound represented by general formula (III) shown below, or a salt thereof, and at least one compound selected from the group consisting of compounds represented by general formula (IV-I) shown below, compounds represented by general formula (IV-II) shown below, compounds represented by general formula (IV-III) shown below and compounds represented by general formula (IV-IV) shown below, or an inorganic acid salt thereof.

公开(公告)号：US11685702B2

公开(公告)日：2023-06-27

申请号：US17113695

申请日：2020-12-07

申请人： JSI Silicone Co.

发明人： Il Nam Jung ,  A Ra Cho ,  Seung Hwan Kang ,  Young Min Kim

IPC分类号： C07C2/86 ,  C07C17/266 ,  C07C15/50 ,  C07C15/58 ,  C07C25/24 ,  C07C15/60 ,  C07C45/69 ,  C07C49/796 ,  C07C15/62 ,  C07C43/285 ,  C07C41/30 ,  C07C15/24 ,  C07C15/16 ,  C07C15/20 ,  C07F7/18 ,  C07C319/20 ,  C07C321/28 ,  C07F7/12 ,  C07C15/44

CPC分类号： C07C2/861 ,  C07C15/16 ,  C07C15/20 ,  C07C15/24 ,  C07C15/44 ,  C07C15/50 ,  C07C15/58 ,  C07C15/60 ,  C07C15/62 ,  C07C17/266 ,  C07C25/24 ,  C07C41/30 ,  C07C43/285 ,  C07C45/69 ,  C07C49/796 ,  C07C319/20 ,  C07C321/28 ,  C07F7/12 ,  C07F7/127 ,  C07F7/1804 ,  C07F7/1892 ,  C07C2603/24 ,  C07C2603/50 ,  C07C2603/52

摘要： Provided is a method for producing (alkyl)arene compounds represented by Formulae 3-1, 3-2, and 3-3 by the Friedel-Crafts alkylation reaction of alkyl halide compounds and arene compounds using organic phosphine compounds as a catalyst.

公开(公告)号：US11679182B2

公开(公告)日：2023-06-20

申请号：US17328531

申请日：2021-05-24

申请人： Warsaw Orthopedic, Inc.

发明人： Roger E. Harrington ,  Jerbrena C. Jacobs ,  Robert Doyle

IPC分类号： C07C319/20 ,  A61L27/58 ,  A61L27/18 ,  C08G18/38 ,  A61L27/40

CPC分类号： A61L27/58 ,  A61L27/18 ,  A61L27/40 ,  C07C319/20 ,  C08G18/3868 ,  A61L2300/40 ,  C07C319/20 ,  C07C323/12

摘要： A method of making a hydroxyl-terminated thioketal diol is provided, the method comprising reacting a thioketal ester with a non-pyrophoric reducing agent to form a hydroxyl-terminated thioketal diol. The hydroxyl-terminated thioketal diol can be 2,2-(propane-2,2-diylbis(sulfanediyl)) diethanol. The non-pyrophoric reducing agent can be a sodium aluminum hydride, for example, sodium bis (2-methoxyethoxy)aluminum hydride. The thioketal ester can be dimethyl 2,2-(propane-2,2-diylbis(sulfanediyl)) diacetate. A biodegradable matrix prepared by reacting a hydroxyl-terminated thioketal diol with an isocyanate is provided. A method of making a biodegradable polyurethane composite is also provided.

公开(公告)号：US20180305302A1

公开(公告)日：2018-10-25

申请号：US15769765

申请日：2016-10-21

申请人： Bayer CropScience Aktiengesellschaft

发明人： Christian FUNKE ,  Thomas HIMMLER ,  Sergii PAZENOK ,  Christoph SCHOTES ,  Matthias BELLER ,  Thomas SCHAREINA ,  Alexander ZAPF

IPC分类号： C07C253/14 ,  C07C319/14 ,  C07C319/20 ,  C07C315/02 ,  C07C25/13 ,  C07C255/50 ,  C07C323/36

CPC分类号： C07C253/14 ,  C07C25/13 ,  C07C255/50 ,  C07C315/02 ,  C07C319/14 ,  C07C319/20 ,  C07C323/36 ,  C07C323/62 ,  C07C317/44

摘要： A process for preparing 2-alkyl-4-trifluoromethyl-3-alkylsulfonylbenzoic acids of the formula (I) is described. Here, the substituents are radicals such as alkyl and substituted phenyl.

公开(公告)号：US20180258031A1

公开(公告)日：2018-09-13

申请号：US15758446

申请日：2016-09-16

申请人： Boehringer Ingelheim International GmbH

发明人： Uwe Joerg Ries ,  Nizar HADDAD ,  Bo QU

IPC分类号： C07C269/06 ,  C07F9/6571 ,  C07D307/58 ,  C07C315/04 ,  B01J31/02

CPC分类号： C07C269/06 ,  B01J31/0258 ,  B01J2231/34 ,  C07B2200/07 ,  C07C315/04 ,  C07C319/20 ,  C07C2601/10 ,  C07C2601/16 ,  C07D307/58 ,  C07D307/66 ,  C07F9/65683 ,  C07F9/6571 ,  C07F9/65744 ,  C07C271/22 ,  C07C323/43 ,  C07C317/50

摘要： The invention relates to a method for the stereoselective preparation of compounds of formula (IV).

公开(公告)号：US10072036B2

公开(公告)日：2018-09-11

申请号：US15306521

申请日：2015-04-24

申请人： UNIVERSITÄT STUTTGART

发明人： Michael R. Buchmeiser ,  Suman Sen ,  Roman Schowner

IPC分类号： C07F11/00 ,  C07C6/04 ,  C08G61/08 ,  C08G61/12 ,  C07C319/20 ,  C07C253/30 ,  C07C67/333 ,  B01J31/18 ,  B01J31/22

CPC分类号： C07F11/00 ,  B01J31/1805 ,  B01J31/2273 ,  B01J31/2278 ,  B01J2231/543 ,  B01J2531/64 ,  B01J2531/66 ,  C07C6/04 ,  C07C67/333 ,  C07C253/30 ,  C07C319/20 ,  C07C2531/22 ,  C07C2601/10 ,  C07C2601/16 ,  C08G61/08 ,  C08G61/12 ,  C08G2261/418 ,  C08G2261/419 ,  C07C13/20 ,  C07C11/02 ,  C07C255/46 ,  C07C321/28 ,  C07C69/74

摘要： The invention relates to an N-heterocyclic carbene complex of general formulas I to IV (I) (II) (III) (IV), according to which A1 stands for NR2 or PR2, A2 stands for CR2 R2′, NR2, PR2, 0 or S, A3 stands for N or P, and C stands for a carbene carbon atom, ring B is an unsubstituted or a mono or poly-substituted 5 to 7-membered ring, substituents R2 and R2′ stand, inter alia, for a linear or branched C1-Cw-alkyl group and, if N and N each stand for NR2 or PR2, are the same or different, M in formulas I, II, III or IV stands for Cr, Mo or W, X 1 or X2 in formulas I to IV are the same or different and represent, inter alia, C1-C1s carboxylates and C1-C1s-alkoxides, Y is inter alia oxygen or sulphur, Z is inter alia a linear or branched C1-Cw-alkylenoxy group, and R 1 and R1′ in formulas I to IV are, inter alia, an aliphatic or aromatic group. These compounds are particularly suitable for use as catalysts for olefin metathesis reactions and have the advantage, compared to known Schrock carbene complexes, of displaying clearly increased tolerance to functional groups such as, in particular, aldehydes, secondary amines, nitriles, carboxylic acids and alcohols.

公开(公告)号：US20180200391A1

公开(公告)日：2018-07-19

申请号：US15741965

申请日：2016-07-05

申请人： PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY

发明人： Takuya Takahashi ,  Tomoyuki Miyazaki ,  Tetsuya Suhara ,  Makoto Higuchi ,  Meiei Cho

IPC分类号： A61K51/04 ,  C07C323/49 ,  C07C319/20 ,  C07B59/00 ,  C07F7/22

CPC分类号： A61K51/04 ,  C07B59/001 ,  C07B59/004 ,  C07B2200/05 ,  C07C319/20 ,  C07C323/49 ,  C07F7/22 ,  C07F7/2208

摘要： The present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. (In the formula, each of A and Z independently represents CO, SO or SO2; each of X and Y independently represents S or O; each of R1-R4 independently represents a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group or a halogen group; each R5 independently represents an alkyl group, an alkenyl group, an alkynyl group or a halogen group; and n represents an integer of 0-4.) This compound is capable of specifically binding to an AMPA receptor, and shows extremely high brain uptake.