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1.发明申请公开(公告)号：US20220233462A1
公开(公告)日：2022-07-28
申请号：US17574933
申请日：2022-01-13
发明人： Gleb SUKHORUKOV , Irina NAZARENKO , Yana TARAKANCHIKOVA , Toni CATHOMEN , Tatjana CORNU , Valentina PENNUCCI , Jamal ALZUBI
IPC分类号： A61K9/51 , A61K31/7105 , A61K31/711
摘要： The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
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公开(公告)号：US20190024072A1
公开(公告)日：2019-01-24
申请号：US15657641
申请日：2017-07-24
发明人： Toni CATHOMEN , Claudio MUSSOLINO , Tatjana I. CORNU , Tafadzwa MLAMBO , Sandra NITSCH , Jamal ALZUBI , Marianna ROMITO
摘要： The present invention concerns a construct for epigenomic modification of genes that includes the following components:a) a Krüppel-associated box zinc finger protein or homologous, b) a DNA region capable of binding to the target gene or homologous, c) a human DNA methyltransferase DNMT3A or homologous and d) a murine DNA methyltransferase Dnmt3L or homologous whereby components a), b), c) and d) are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier which can be used to silence genes coding for a protein in leukocytes which avoids the internalization of HI viruses in immune cells.
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公开(公告)号：US20190024090A1
公开(公告)日：2019-01-24
申请号：US15950403
申请日：2018-04-11
发明人： Toni CATHOMEN , Claudio MUSSOLINO , Tatjana I. CORNU , Tafadzwa MLAMBO , Sandra NITSCH , Jamal ALZUBI , Marianna ROMITO
IPC分类号： C12N15/113 , C07K14/47 , C12N9/10 , C12N15/86
摘要： The present invention concerns a construct for epigenomic modification of genes comprising the following components:a) a Krüppel-associated box zinc finger protein or homologous, b) a DNA region capable of binding to the target gene or homologous, c) a human DNA methyltransferase DNMT3A or homologous and d) a murine DNA methyltransferase Dnmt3L or homologous whereby components a), b), c) and d) are linked to each other either directly or via at least one linker. The construct is a designer epigenome modifier which can be used to silence genes coding for a protein in leukocytes which avoids the internalization of HI viruses in immune cells.
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公开(公告)号：US20210371491A1
公开(公告)日：2021-12-02
申请号：US17255546
申请日：2019-06-17
发明人： Toni CATHOMEN , Jamal ALZUBI , Viviane DETTMER , Philipp WOLF , Susanne SCHULTZE-SEEMANN , Irina KUCKUCK , Hinrich ABKEN , Johannes KUEHLE
IPC分类号： C07K14/725 , C07K16/30 , A61K45/06 , A61P35/00 , A61K35/17 , C07K14/705
摘要： The present invention relates to a novel chimeric antigen receptor (CAR) comprising an antigen-binding fragment which binds specifically to PSMA antigen, and a method of manufacturing high-quality CAR T cell products by transfection and/or transduction of T cells therewith, which allows to eradicate tumors in vivo alone or in combination with pharmaceutical drugs, such chemotherapies, biopharmaceutical drugs, such as antibodies, or small-molecule drugs, such as protein kinase inhibitors.
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公开(公告)号：US20230039030A1
公开(公告)日：2023-02-09
申请号：US17788723
申请日：2020-12-14
摘要： The present invention relates to a novel chimeric antigen receptor (CAR) comprising an antigen-binding fragment which binds specifically to PSMA antigen, and a method of manufacturing high-quality CAR T cell products by transfection and/or transduction of T cells therewith, which allows to effectively treat tumors in vivo alone or in combination with pharmaceutical drugs, such chemotherapies, biopharmaceutical drugs, such as antibodies, or small-molecule drugs, such as protein kinase inhibitors.
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6.发明申请公开(公告)号：US20200375914A1
公开(公告)日：2020-12-03
申请号：US16634060
申请日：2018-07-25
发明人： Gleb SUKHORUKOV , Irina NAZARENKO , Yana TARAKANCHIKOVA , Toni CATHOMEN , Tatjana CORNU , Valentina PENNUCCI , Jamal ALZUBI
IPC分类号： A61K9/51 , A61K31/7105 , A61K31/711
摘要： The present invention relates to a biodegradable multilayer nanocapsule for the delivery of at least one biologically active agent into at least one target cell consisting of at least two layers of at least two biodegradable polymers which are laid one onto the other and whereby the biologically active agent is layered onto a layer of a biodegradable polymer and covered with a further layer of a biodegradable polymer, whereby one biologically active agent is a nucleic acid.
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