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    Bis-Platinum Complexes With Antitumor Activity
    1.
    发明申请
    Bis-Platinum Complexes With Antitumor Activity 有权
    具有抗肿瘤活性的双铂配合物

    公开(公告)号：US20100292322A1

    公开(公告)日：2010-11-18

    申请号：US12086547

    申请日：2006-12-21

    申请人： Alberto Bernareggi ,  Mario Grugni ,  Giulio Mariotti ,  Ernesto Menta ,  Gianluca Pardi ,  Paolo Pavesi ,  Gabriella Pezzoni ,  Paolo Nicoli ,  Sergio De Munari

    发明人： Alberto Bernareggi ,  Mario Grugni ,  Giulio Mariotti ,  Ernesto Menta ,  Gianluca Pardi ,  Paolo Pavesi ,  Gabriella Pezzoni ,  Paolo Nicoli ,  Sergio De Munari

    IPC分类号： A61K31/28 ,  C07F15/00 ,  A61P35/00

    CPC分类号： C07F15/0093

    摘要： A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of —B—, —B—(CH2)r—B—, —B—(CH2)r—B—(CH2)z—B—, wherein r and z are an integer from 2 to 8, B is a —NR1— or —N(R2)2+ 1/pQ−p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q−p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO− wherein R3 has the same meanings as R, independently from one another and R4—O—SO3− wherein R4 is (C2-C14)alkyl with the proviso that, when Q−p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.

    摘要翻译： 通式（I）的化合物：其中：R选自（C 1 -C 25）烷基，（C 2 -C 25）烯基，芳基，（C 7 -C 10）芳烷基; n和m各自独立地为2至8的整数; p是一两个; A选自-B-，-B-（CH2）r-B-，-B-（CH2）r-B-（CH2）z-B-，其中r和z是2的整数 至（C 1 -C 4）烷基，（C 1 -C 4）酰基，叔丁氧基羰基，C 1 -C 4烷基， 并且R 2选自氢和（C 1 -C 4）烷基; Q-p是选自氯化物，溴化物，碘化物，硝酸盐，硫酸盐，硫酸氢盐，高氯酸盐，R3COO-中的一种阴离子，其中R3具有与R相同的含义，R4-O-SO3-，其中R4是（C2 -C 14）烷基，条件是当Q-p选自氯化物，溴化物，碘化物，硝酸盐，硫酸盐，硫酸氢盐，高氯酸盐时，R不是（C 1 -C 4）烷基。

    Bis-platinum complexes with antitumor activity
    2.
    发明授权
    Bis-platinum complexes with antitumor activity 有权
    具有抗肿瘤活性的双铂配合物

    公开(公告)号：US08426625B2

    公开(公告)日：2013-04-23

    申请号：US12086547

    申请日：2006-12-21

    申请人： Alberto Bernareggi ,  Mario Grugni ,  Giulio Mariotti ,  Ernesto Menta ,  Gianluca Pardi ,  Paolo Pavesi ,  Gabriella Pezzoni ,  Paolo Nicoli ,  Sergio De Munari

    发明人： Alberto Bernareggi ,  Mario Grugni ,  Giulio Mariotti ,  Ernesto Menta ,  Gianluca Pardi ,  Paolo Pavesi ,  Gabriella Pezzoni ,  Paolo Nicoli ,  Sergio De Munari

    IPC分类号： C07F15/00 ,  A61K31/28

    CPC分类号： C07F15/0093

    摘要： A compound of general formula (I): in which: R is selected from the group consisting of (C1-C25)alkyl, (C2-C25)alkenyl, aryl, (C7-C10)aralkyl; n and m are each independently an integer of two to eight; p is one or two; A is selected from the group consisting of —B—, —B—(CH2)r—B—, —B—(CH2)r—B—(CH2)z—B—, wherein r and z are an integer from 2 to 8, B is a —NR1— or —N(R2)2+1/pQ−p group, in which R1 is selected from hydrogen, (C1-C4)alkyl, (C1-C4)acyl, tert-butoxycarbonyl, and R2 is selected from hydrogen and (C1-C4)alkyl; Q−p is an anion selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R3COO− wherein R3 has the same meanings as R, independently from one another and R4—O—SO3− wherein R4 is (C2-C14)alkyl with the proviso that, when Q−p is selected from chloride, bromide, iodide, nitrate, sulphate, hydrogen sulphate, perchlorate, R is not (C1-C4)alkyl.

    摘要翻译： 通式（I）的化合物：其中：R选自（C 1 -C 25）烷基，（C 2 -C 25）烯基，芳基，（C 7 -C 10）芳烷基; n和m各自独立地为2至8的整数; p是一两个; A选自-B-，-B-（CH2）rB-，-B-（CH2）rB-（CH2）zB-，其中r和z是2至8的整数，B是 -NR 1 - 或-N（R 2）2 + 1 / pQ-p基团，其中R 1选自氢，（C 1 -C 4）烷基，（C 1 -C 4）酰基，叔丁氧基羰基和R 2选自氢 和（C 1 -C 4）烷基; Qp是选自氯化物，溴化物，碘化物，硝酸盐，硫酸盐，硫酸氢盐，高氯酸盐，R 3 COO-中的一种阴离子，其中R 3具有与R相同的含义，R 4 -O-SO 3 - 其中R 4是（C 2 -C 14 ）烷基，条件是当Qp选自氯化物，溴化物，碘化物，硝酸盐，硫酸盐，硫酸氢盐，高氯酸盐时，R不是（C 1 -C 4）烷基。