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1.发明授权Linear basic compounds having NK-2 antagonist activity and formulations thereof 有权具有NK-2拮抗剂活性的线性碱性化合物及其制剂公开(公告)号：US07273856B2
公开(公告)日：2007-09-25
申请号：US10494077
申请日：2002-10-28
申请人： Alessandro Sisto , Valerio Caciagli , Maria Altamura , Alessandro Giolitti , Valentina Fedi , Antonio Guidi , Danilo Giannotti , Nicholas Harmat , Rossano Nannicini , Franco Pasqui , Carlo Alberto Maggi
发明人： Alessandro Sisto , Valerio Caciagli , Maria Altamura , Alessandro Giolitti , Valentina Fedi , Antonio Guidi , Danilo Giannotti , Nicholas Harmat , Rossano Nannicini , Franco Pasqui , Carlo Alberto Maggi
IPC分类号： A61K31/455 , A61K31/535 , C07D265/30 , C07D211/82 , C07D207/00
CPC分类号： C07D409/12 , A61K38/00 , C07D333/70 , C07K5/06026 , C07K5/06034 , C07K5/06078
摘要： Described herein are compounds of formula (I) useful as antagonists of tachykinins in general, and in particular of neurokinin A; and the pharmaceutical formulations comprising the compounds of formula (I)
摘要翻译： 本文描述的是通式（I）的化合物，其通常用作速激肽拮抗剂，特别是神经激肽A; 和包含式（I）化合物的药物制剂，
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2.发明申请N-Hydroxyamides Omege-Substituted with Tricyclic Groups as Histone Deacetylase Inhibitors, Their Preparation and Use in Pharmaceutical Formulations 审中-公开用三元环作为组蛋白脱乙酰酶抑制剂取代的N-羟基酰胺，它们在药物制剂中的制备和用途公开(公告)号：US20080275023A1
公开(公告)日：2008-11-06
申请号：US11886168
申请日：2006-03-13
IPC分类号： A61K31/554 , C07D243/14 , C07D285/36 , A61P3/10 , A61K31/7068 , A61K31/551
CPC分类号： C07D243/38 , C07D267/20 , C07D281/16 , C07D285/36 , C07D291/08 , C07D401/06 , C07D471/04 , C07D473/16 , C07D495/04
摘要： New N-hydroxyamides of n-alkyl carboxylic acids omega substituted with suitable tricyclic systems characterised by a central 7-membered ring, having activity as inhibitors of histone deacetylase (HDAC).
摘要翻译： 新的N-烷基羧酸的N-羟基酰胺被以合适的三环系统取代，其特征在于以中枢7-元环为特征，具有作为组蛋白脱乙酰酶（HDAC）抑制剂的活性。
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