公开(公告)号：US08420372B2

公开(公告)日：2013-04-16

申请号：US12676016

申请日：2008-09-04

申请人： Alexander Bello ,  Michael Gray ,  Heinz Feldmann ,  Gary Kobinger

发明人： Alexander Bello ,  Michael Gray ,  Heinz Feldmann ,  Gary Kobinger

IPC分类号： C12N7/02 ,  C12N15/86 ,  A61K48/00

CPC分类号： C12N7/00 ,  A61K48/0091 ,  C07K14/005 ,  C12N15/86 ,  C12N2500/10 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143

摘要： Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.

摘要翻译： 筛选猪组织存在腺相关病毒（AAV）。 从各种猪组织中分离出几种AAV序列，BLAST分析确认了与不同来源的已知AAV序列的高至低同源性。 序列分析证实分离至少三种我们命名为AAVpo1，-po2和-po3的新型猪AAV分离物。 衍生自猪组织的新型AAV可显着促成人类可接受的新型预防或治疗性临床方式的产生。

公开(公告)号：US20100272685A1

公开(公告)日：2010-10-28

申请号：US12676016

申请日：2008-09-04

申请人： Alexander Bello ,  Michael Gray ,  Heinz Feldmann ,  Gary Kobinger

发明人： Alexander Bello ,  Michael Gray ,  Heinz Feldmann ,  Gary Kobinger

IPC分类号： A61K35/76 ,  C12N7/00 ,  A61P7/00 ,  A61P11/00 ,  A61P21/00 ,  A61P25/00

CPC分类号： C12N7/00 ,  A61K48/0091 ,  C07K14/005 ,  C12N15/86 ,  C12N2500/10 ,  C12N2750/14121 ,  C12N2750/14122 ,  C12N2750/14143

摘要： Porcine tissues were screened for the presence of Adeno-Associated Viruses (AAV). Several AAV sequences were isolated from various porcine tissues, and BLAST analysis confirmed high to low homology with known AAV sequences of different origin. Sequence analysis confirmed the isolation of at least three novel porcine AAV isolates which we named AAVpo1, -po2, and -po3. Novel AAVs derived from porcine tissues may significantly contribute to the generation of new preventive or curative clinical modalities acceptable for human use.

摘要翻译： 筛选猪组织存在腺相关病毒（AAV）。 从各种猪组织中分离出几种AAV序列，BLAST分析确认了与不同来源的已知AAV序列的高至低同源性。 序列分析证实分离至少三种我们命名为AAVpo1，-po2和-po3的新型猪AAV分离物。 衍生自猪组织的新型AAV可显着促成人类可接受的新型预防或治疗性临床方式的产生。