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    Sulfuric acid esters of sugar alcohols
    1.
    发明授权
    Sulfuric acid esters of sugar alcohols 失效
    糖醇的硫酸酯

    公开(公告)号：US5830920A

    公开(公告)日：1998-11-03

    申请号：US639986

    申请日：1996-04-26

    申请人： Alexander Chucholowski ,  Jurgen Fingerle ,  Niggi Iberg ,  Hans Peter Marki ,  Rita Muller ,  Michael Pech ,  Marianne Rouge ,  Gerard Schmid ,  Thomas Tschopp ,  Hans Peter Wessel

    发明人： Alexander Chucholowski ,  Jurgen Fingerle ,  Niggi Iberg ,  Hans Peter Marki ,  Rita Muller ,  Michael Pech ,  Marianne Rouge ,  Gerard Schmid ,  Thomas Tschopp ,  Hans Peter Wessel

    IPC分类号： C07D251/70 ,  A61K31/165 ,  A61K31/27 ,  A61K31/35 ,  A61K31/352 ,  A61K31/53 ,  A61K31/70 ,  A61K31/7028 ,  A61P7/02 ,  A61P9/10 ,  A61P31/12 ,  A61P43/00 ,  C07C305/06 ,  C07C305/10 ,  C07D311/22 ,  C07H15/18 ,  A61K31/045 ,  C07C205/00

    CPC分类号： C07H15/18 ,  C07C305/06 ,  C07C305/10

    摘要： Compounds of the formula ##STR1## wherein n.sup.1 -n.sup.9 are each independently 0 or 1; m.sup.1 -m.sup.9 are each independently 0 or 1, but with the proviso that at least one of m.sup.1, m.sup.2 and m.sup.3, at least one of m.sup.4, m.sup.5 and m.sup.6 and, when present, at least one of m.sup.7, m.sup.8 and m.sup.9 is 1; and wherein X.sup.1 -X.sup.18 each independently is --O--, --CONR.sup.1,--NR.sup.1 CO-- or --NR.sup.1 --; R.sup.1 is hydrogen or lower alkyl; W is a benzene or s-triazine; Y.sup.1 -Y.sup.9 each independently is an aromatic ring systems; A.sup.1 -A.sup.3 each independently is a residue of a sugar alcohol devoid of the 1-hydroxy group or a derivative thereof, a residue of a sugar acid devoid of the 1-carboxy group or a derivative thereof or tris-(hydroxymethyl)-methyl; D is the di-residue of a sugar alcohol devoid of 2 hydroxy groups or a derivative thereof or the di-residue of a sugar dicarboxylic acid devoid of 2 carboxy group or a derivative thereof; Q.sup.1 -Q.sup.3 and Z.sup.1 -Z3 each independently are the di-residue of a sugar alcohol devoid of 2 hydroxy groups or a derivative thereof or the di-residue of a sugar dicarboxylic acid devoid of 2 carboxy groups or a derivative thereof or didesoxyglycopyranoside or a derivative thereof, wherein at least one hydroxy group of residues A.sup.1 -A.sup.3, D, Q.sup.1 -Q.sup.3 and Z.sup.1 -Z.sup.3 is esterified with sulfuric acid, and pharmaceutically usable salts thereof are useful for the treatment of disorders which are characterized by excessive or destructive proliferation of smooth muscle cells.

    摘要翻译： 式Ia的化合物或其中n1-n9各自独立地为0或1; m1-m9各自独立地为0或1，但条件是m1，m2和m3中的至少一个，m4，m5和m6中的至少一个，并且当存在时，m7，m8和m9中的至少一个为1 ; 并且其中X1-X18各自独立地为-O - ， - CONR1，-NR1CO-或-NR1-; R1是氢或低级烷基; W是苯或s-三嗪; Y1-Y9各自独立为芳环体系; A1-A3各自独立地为不含1-羟基或其衍生物的糖醇的残基，不含1-羧基的糖酸或其衍生物的残基或三 - （羟甲基） - 甲基; D是不含2个羟基的糖醇或其衍生物或不含2个羧基的糖二羧酸的二残基或其衍生物的二残基; Q1-Q3和Z1-Z3各自独立地为不含2个羟基的糖醇或其衍生物或不含2个羧基的糖二羧酸的二残基或其衍生物或二脱氧吡喃葡萄糖苷或二 其衍生物，其中残基A1-A3，D，Q1-Q3和Z1-Z3中的至少一个羟基用硫酸酯化，其药学上可用的盐可用于治疗以过度或破坏性增殖为特征的病症 的平滑肌细胞。