公开(公告)号：US5338524A

公开(公告)日：1994-08-16

申请号：US997368

申请日：1992-12-23

申请人： Alexander Maurer ,  Guenter Raab ,  Gudrun Raab ,  Hans-Georg Steinert ,  Richard Taenzler

发明人： Alexander Maurer ,  Guenter Raab ,  Gudrun Raab ,  Hans-Georg Steinert ,  Richard Taenzler

IPC分类号： A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  C01B25/32

CPC分类号： C01B25/322

摘要： The present invention provides a process and apparatus for the production of coarse-grained dicalcium phosphate anhydride, at least 95% of which consists of particles with a grain diameter of >45 .mu.m, wherein, at a temperature of 60.degree. to 100.degree. C., a highly reactive calcium component, for example freshly slaked milk of lime or an aqueous slurry or suspension of calcium hydroxide and/or calcium carbonate, is introduced directly into the stirrer zones of a vessel containing aqueous phosphoric acid and having one or more turbulent stirrer zones. An equivalent amount of aqueous phosphoric acid is introduced into another zone of the vessel, the speed of introduction being so regulated that a pH value of 3.0 to 4.5 is obtained in the stirrer zone and the whole batch or a continuously or semi-continuously removed part thereof is cooled to 40.degree. to 60.degree. C. The removed part then is mixed with an additional calcium component, for example milk of lime, to obtain a pH value of from 5.5 to 6.8, the mixture further stirred for 10 to 60 minutes and the resultant course-grained dicalcium phosphate anhydride is filtered off and dried.

摘要翻译： 本发明提供了一种生产粗粒磷酸二钙酸酐的方法和装置，其中至少95％由粒径>45μm的颗粒组成，其中在60℃至100℃的温度下 将高活性钙组分，例如石灰的新鲜熟化的牛奶或氢氧化钙和/或碳酸钙的水性浆料或悬浮液直接引入含有磷酸水溶液的容器的搅拌器区域中并具有一个或多个湍流 搅拌区。 将等量的磷酸水溶液引入到容器的另一区域中，引入速度被调节到在搅拌器区域和整个批料中获得3.0至4.5的pH值，或者连续或半连续地除去部分 将其除去与另外的钙成分（例如石灰乳）混合，得到5.5〜6.8的pH值，进一步搅拌10〜60分钟， 将所得的过程粒度的磷酸二钙酸酐滤出并干燥。

公开(公告)号：US5405436A

公开(公告)日：1995-04-11

申请号：US126969

申请日：1993-09-27

申请人： Alexander Maurer ,  Gudrun Raab ,  Guenter Raab ,  Reinhold Schmitt ,  Detlev Schober ,  Richard Taenzler

发明人： Alexander Maurer ,  Gudrun Raab ,  Guenter Raab ,  Reinhold Schmitt ,  Detlev Schober ,  Richard Taenzler

IPC分类号： A61K8/00 ,  A61K8/24 ,  A61Q11/00 ,  C01B25/32 ,  D06P1/649 ,  D06P3/52 ,  D06P3/54 ,  A61K7/16

CPC分类号： D06P3/54 ,  A61K8/24 ,  A61Q11/00 ,  C01B25/322 ,  D06P1/6491 ,  D06P3/523

摘要： A process for the preparation of a hydroxyapatite, which is suitable as a tooth-cleaning substance, by precipitation from aqueous phosphoric acid and calcium hydroxide solution, in which a calcium-doped phosphoric acid solution is fed to an intensive mixer with a suspension of calcium hydroxide/oxide in a molar ratio of Ca:P=1.667 corresponding to the hydroxyapatite of and reacted there at precipitation temperatures of 60.degree.-100.degree. C., preferably 80.degree.-90.degree. C. and a pH of 4-8, preferably of 6.5-7.5. Also disclosed in a tooth-cleaning substance containing the hydroxyapatite.

摘要翻译： 通过从磷酸水溶液和氢氧化钙水溶液中沉淀制备适合作为牙齿清洁物质的羟基磷灰石的方法，其中将掺入磷酸的磷酸溶液加入到具有钙悬浮液的浓缩混合器中 氢氧化物/氧化物，其摩尔比为：对应于羟基磷灰石的Ca：P = 1.667，在60℃-100℃，优选80-90℃的沉淀温度和4-8℃的pH下反应 为6.5-7.5。 还公开在含有羟基磷灰石的牙齿清洁物质中。