公开(公告)号：US20120156257A1

公开(公告)日：2012-06-21

申请号：US13329999

申请日：2011-12-19

申请人： Alexandre Drogoz ,  Alain Constancis

发明人： Alexandre Drogoz ,  Alain Constancis

IPC分类号： A61K9/00 ,  B82Y40/00 ,  B82Y5/00

CPC分类号： A61K9/5146 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/5192 ,  A61K31/00 ,  A61K47/645 ,  A61K47/6935 ,  B82Y5/00

摘要： The present invention relates to a novel method for the preparation of nanoparticles with a diameter smaller than or equal to 500 nm, comprising bringing a solution (1) comprising nanoparticles of a first polyelectrolyte in the charged state, bearing hydrophobic side groups, together with (2) at least one second polyelectrolyte of opposite polarity to that of the first polyelectrolyte, characterized in that the ratio Z of the number of cationic groups relative to the number of anionic groups in the mixture of the two polyelectrolytes is comprised between 0.1 and 0.75 or between 1.3 and 2; and the total mass concentration C of polyelectrolytes is strictly less than 2 mg/g of the mixture.

摘要翻译： 本发明涉及一种制备直径小于或等于500nm的纳米颗粒的新方法，包括将包含第一聚电解质纳米颗粒的带有疏水侧基的纳米颗粒的溶液（1）与（ 2）至少一种与第一聚电解质相反极性的第二聚电解质，其特征在于阳离子基团数目相对于两种聚电解质混合物中的阴离子基团数目的Z的比率为0.1至0.75或 在1.3和2之间; 聚电解质的总质量浓度C严格小于2mg / g的混合物。