公开(公告)号：US10081668B2

公开(公告)日：2018-09-25

申请号：US15497822

申请日：2017-04-26

申请人： Northwestern University ,  Board of Regents of the University of Nebraska

发明人： Jack Henkin ,  Olga Volpert ,  Serguei Vinogradov ,  Ignacio Melgar-Asensio

IPC分类号： C07K14/81 ,  A61K47/48 ,  C07K7/06 ,  C07K19/00 ,  A61K38/00

CPC分类号： C07K14/8121 ,  A61K38/00 ,  A61K47/54 ,  A61K47/542 ,  A61K47/55 ,  A61K47/61 ,  A61K47/64 ,  A61K47/6903 ,  A61K47/6921 ,  A61K47/6935 ,  A61K47/6939 ,  C07K7/06 ,  C07K19/00

摘要： Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents, chemotherapy-protecting agents, and immune stimulating agents.

公开(公告)号：US10071056B2

公开(公告)日：2018-09-11

申请号：US15046817

申请日：2016-02-18

申请人： Pfizer Inc.

发明人： Stephen E. Zale ,  Mir Mukkaram Ali

IPC分类号： B82Y5/00 ,  A61K9/16 ,  A61K9/51 ,  A61K31/197 ,  A61K31/337 ,  C07C275/24 ,  C08G63/664 ,  C07C275/16 ,  C08G63/685 ,  C08G63/692 ,  A61K47/34 ,  A61K9/14 ,  A61K31/136 ,  A61K31/704 ,  A61K47/60 ,  A61K47/54 ,  A61K47/69

CPC分类号： A61K9/1647 ,  A61K9/146 ,  A61K9/5153 ,  A61K9/5192 ,  A61K31/136 ,  A61K31/197 ,  A61K31/337 ,  A61K31/704 ,  A61K47/34 ,  A61K47/542 ,  A61K47/60 ,  A61K47/6935 ,  A61K47/6937 ,  B82Y5/00 ,  C07C275/16 ,  C07C275/24 ,  C08G63/664 ,  C08G63/6852 ,  C08G63/6922 ,  Y10S977/904 ,  Y10S977/905 ,  Y10S977/906 ,  Y10S977/911 ,  Y10S977/915

摘要： The present invention generally relates to polymers and macromolecules, in particular, to polymers useful in particles such as nanoparticles. One aspect of the invention is directed to a method of developing nanoparticles with desired properties. In one set of embodiments, the method includes producing libraries of nanoparticles having highly controlled properties, which can be formed by mixing together two or more macromolecules in different ratios. One or more of the macromolecules may be a polymeric conjugate of a moiety to a biocompatible polymer. In some cases, the nanoparticle may contain a drug. Other aspects of the invention are directed to methods using nanoparticle libraries.

公开(公告)号：US20180243443A1

公开(公告)日：2018-08-30

申请号：US15553855

申请日：2016-03-03

申请人： UNIVERSITY OF MIAMI

发明人： Paolo Serafini ,  Jennifer Vella ,  Vicenzo Bronte ,  Pirouz Daftarian ,  Angel Kaifer ,  Serena Zilio

IPC分类号： A61K47/69 ,  C12N15/113 ,  A61K47/59 ,  A61K49/00 ,  A61K47/64 ,  A61K31/683 ,  A61K31/713 ,  A61P35/00

CPC分类号： A61K47/6935 ,  A61K31/683 ,  A61K31/713 ,  A61K47/595 ,  A61K47/642 ,  A61K49/0004 ,  A61P35/00 ,  C12N15/1135 ,  C12N2310/122 ,  C12N2310/141 ,  C12N2310/3513 ,  C12N2310/531

摘要： Described herein are nanoparticle-based compositions, kits and methods and platforms for delivering one or more nucleic acids to a myeloid cell.

公开(公告)号：US20180243226A1

公开(公告)日：2018-08-30

申请号：US15757608

申请日：2016-09-02

申请人： Yale University

发明人： Tarek M. Fahmy ,  Jung Seok Lee ,  Dongin Kim

IPC分类号： A61K9/51 ,  A61K9/00 ,  A61K47/69 ,  A61K38/28 ,  A61K9/08 ,  A61K51/12 ,  A61K49/18 ,  A61P3/10 ,  A61P1/18 ,  A61K31/436 ,  A61P1/00 ,  A61P29/00

CPC分类号： A61K9/5146 ,  A61K9/0053 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/5153 ,  A61K31/436 ,  A61K38/28 ,  A61K45/00 ,  A61K47/6935 ,  A61K49/1824 ,  A61K51/1244 ,  A61P1/00 ,  A61P1/18 ,  A61P3/10 ,  A61P29/00

摘要： Pharmaceutical composition containing poly(bile) acid (PBA) polymers for oral delivery of agent(s) show enhanced uptake by the pancreas, liver, and colon. These nanoparticles show significant retention in the pancreas and colon and are therefore useful for selective delivery. The examples demonstrate efficacy of oral administration of insulin to treat diabetes, and oral induction of tolerance by administration of insulin or ovalbumin in combination with rapamycin. Diabetic animals treated with the insulin or insulin with rapamycin showed normalization of blood glucose levels.

公开(公告)号：US10058622B2

公开(公告)日：2018-08-28

申请号：US15595135

申请日：2017-05-15

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： I-Wei Chen ,  Hoon Choi ,  Rong Zhou

IPC分类号： A61K38/00 ,  A61K47/69 ,  A61K31/416 ,  A61K31/337 ,  A61K31/433 ,  A61K9/00 ,  C12N15/113 ,  A61K31/713 ,  A61K47/64 ,  C07K7/06

CPC分类号： A61K47/6929 ,  A61K9/0019 ,  A61K9/5169 ,  A61K31/337 ,  A61K31/416 ,  A61K31/433 ,  A61K31/713 ,  A61K45/06 ,  A61K47/60 ,  A61K47/64 ,  A61K47/645 ,  A61K47/6909 ,  A61K47/6935 ,  C07K7/06 ,  C07K7/08 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/3513 ,  C12N2320/32 ,  C12N2320/51 ,  A61K2300/00

摘要： A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH-sensitive hydrophilic and hydrophobic amino acids in the backbone. As the pH environment changes from physiological pH level to a weakly acidic environment such as near a tumor site (pH.about.6.5-6.9), the peptides may dissolve, releasing the biological substance. Also provided are the delivery methods and related kits.

公开(公告)号：US20180140718A1

公开(公告)日：2018-05-24

申请号：US15578292

申请日：2016-06-01

申请人： University of Florida Research Foundation, Inc.

发明人： JOHN HARDY ,  CHRISTINE E. SCHMIDT

IPC分类号： A61K47/69 ,  C08G73/02

CPC分类号： A61K47/6935 ,  A61N1/30 ,  A61N1/325 ,  C08G69/10 ,  C08G73/0266 ,  C08G73/028

摘要： Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.

公开(公告)号：US20180125791A1

公开(公告)日：2018-05-10

申请号：US15572862

申请日：2016-05-10

申请人： THE UNIVERSITY OF MASSACHUSETTS

发明人： Vincent M. Rotello ,  Ryan F. Landis ,  Moumita Ray

IPC分类号： A61K9/51 ,  B01J13/02 ,  A61K47/69 ,  C08G61/12 ,  C08G61/08

CPC分类号： A61K9/5146 ,  A61K47/6935 ,  B01J13/02 ,  C08G61/08 ,  C08G61/12 ,  C08G61/123 ,  C08G2261/1424 ,  C08G2261/1432 ,  C08G2261/3324 ,  C08G2261/3342 ,  C08G2261/418

摘要： A nanocapsule includes a shell including a polymer and a protein, a nucleic acid, or a combination thereof. The polymer has repeating units of Formula (I) (I) wherein X, L1, R1, and y are as described herein. The nanocapsule further includes a core comprising an oil. A composition is also disclosed including a plurality of the nanocapsules dispersed in an aqueous solution. The nanocapsules prepared according to the methods described herein are particularly useful for the delivery of proteins and nucleic acids into cells.

公开(公告)号：US20180117154A1

公开(公告)日：2018-05-03

申请号：US15852293

申请日：2017-12-22

申请人： NEW PHASE LTD.

发明人： Raphael HOF ,  Raz KHANDADASH ,  Ella FREMDER

IPC分类号： A61K41/00 ,  A61N1/40 ,  A61K47/60 ,  A61K47/69 ,  A61K47/06

CPC分类号： A61K41/0052 ,  A61F7/00 ,  A61K47/06 ,  A61K47/549 ,  A61K47/60 ,  A61K47/6929 ,  A61K47/6935 ,  A61N1/406

摘要： Apparatus and methods are described for use with a subject suffering from cancer. A nanoparticle (22) includes an inner core (30) that comprises a phase-change material that is configured to absorb latent heat of fusion by undergoing a phase change. An outer layer (32) disposed around the inner core includes a plurality of nano-spheres (34) of at least one metal, and a plurality of molecules (38) of a substance that binds preferentially with cancerous cells relative to non-cancerous cells. The nanoparticle has a volume of at least 65,000 nm3 and is elongatable into an ellipsoid, such that, when the nanoparticle is maximally elongated, each of the semi-axes defined by the ellipsoid is greater than 5 nm, and at least two of the semi axes of the ellipsoid are less than 30 nm. Other applications are also described.

公开(公告)号：US09919058B2

公开(公告)日：2018-03-20

申请号：US15326387

申请日：2015-07-08

申请人： THE UNITED STATES OF AMERICA, as represented by the Secretary of Health and Human Services

发明人： Dennis M. Klinman ,  Takashi Sato

IPC分类号： C12N15/117 ,  A61K47/48 ,  A61K31/7088 ,  A61K31/475

CPC分类号： A61K47/6931 ,  A61K9/0019 ,  A61K9/0073 ,  A61K9/5123 ,  A61K31/4745 ,  A61K31/475 ,  A61K31/7088 ,  A61K31/711 ,  A61K45/06 ,  A61K47/08 ,  A61K47/6935 ,  A61K2300/00

摘要： Methods are disclosed herein for treating a subject with a lung cancer. The lung cancer can be small cell carcinoma of the lung or non-small cell carcinoma of the lung.The methods include locally administering to the subject a therapeutically effective amount of the polyketal particle comprising a CpG oligodexoynucleotide. Optionally, the polyketal particle can include an imidazoquinoline compound.

公开(公告)号：US20180049977A1

公开(公告)日：2018-02-22

申请号：US15683470

申请日：2017-08-22

申请人： Donald L. Elbert ,  Jacob Roam

发明人： Donald L. Elbert ,  Jacob Roam

IPC分类号： A61K9/00 ,  A61K47/36 ,  A61K47/69 ,  C08B37/00

CPC分类号： A61K9/0024 ,  A61K47/36 ,  A61K47/65 ,  A61K47/6903 ,  A61K47/6933 ,  A61K47/6935 ,  C07K14/475 ,  C07K14/4756 ,  C07K14/78 ,  C08B37/0075 ,  C08B37/0081

摘要： Disclosed herein is a device and method for regenerating tissue using a modular scaffold having a gradient of enzymatic degradability. The disclosure further relates to scaffolds made of microparticles comprising a cross-linked water-soluble polymer or cross-linked water-soluble polymers and a process for forming thereof.