公开(公告)号：US20170000773A1

公开(公告)日：2017-01-05

申请号：US14791280

申请日：2015-07-03

申请人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich lvashchenko ,  Nikolay Filippovich Savchuk

发明人： Alexandre Vasilievich Ivachtchenko ,  Andrey Alexandrovich lvashchenko ,  Nikolay Filippovich Savchuk

IPC分类号： A61K31/437 ,  A61K31/444

CPC分类号： A61K31/437 ,  A61K31/444 ,  C07D471/04

摘要： The present invention relates to a method of antagonizing a 5-HT6 serotonin receptor, comprising administering to the cell a compound of formula 1.2, or a pharmaceutically acceptable salt thereof, wherein: R1 is a C1-C5 alkyl; R2i is independently hydrogen, halogen, a C1-C3 alkyl, CF3, OCF3 or OCH3; i is 1, 2, 3 or 4; Ar is an unsubstituted phenyl or a substituted phenyl substituted with halogen, C1-C6 alkyl, C1-C6 alkoxy, substituted amino group or trifluoromethyl; or Ar is a substituted or unsubstituted 6-membered aromatic heterocycle with one or two nitrogen atoms in the heterocycle. The invention also relates to pharmaceutical compositions and method for treating a cognitive disorder or neurodegenerative disease in a subject in need thereof comprising administering an effective dose to the subject of a compound of formula 1.2 according to claim 1, or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明还涉及用于治疗有需要的受试者的认知障碍或神经变性疾病的药物组合物和方法，其包括向所述受试者施用根据权利要求1的式1.2化合物或其药学上可接受的盐的有效剂量。