公开(公告)号：US06330475B1

公开(公告)日：2001-12-11

申请号：US09454965

申请日：1999-12-06

申请人： Alexis C Renirie ,  Vincent Schouten ,  Koen Weijand

发明人： Alexis C Renirie ,  Vincent Schouten ,  Koen Weijand

IPC分类号： A61N139

CPC分类号： A61N7/00 ,  A61B2017/00703 ,  A61N1/395 ,  A61N1/3956

摘要： There is provided an implanted system and method for delivering subsonic mechanical waves to one or more selected patient areas, said areas including the patient's heart and/or lungs. The mechanical waves are delivered for the purpose of treating fibrillation or like arrhythmias, for enhancing lung gas exchange, enhancing cardiac muscle fiber relaxation, and enhancing coronary perfusion. Mechanical waves are generated in a frequency range of about 1,100,000 Hz, and preferably 1-50,000 Hz. The waves may be delivered continuously for short or long time periods, or may be controlled in timing either with respect to detected portions of a patient's heartbeat signal or in response to a detected event such as fibrillation. In one preferred embodiment, the implantable system includes a defibrillation shock generator and control for responding to a defibrillation event by first delivering a sequence of mechanical waves and then delivering an electrical defibrillation shock. In another embodiment, the system and method treat incipient fibrillation or arrhythmia by delivering mechanical waves of predetermined timing to the patient's heart and/or lungs. In a specific embodiment, mechanical waves are delivered through an array of transducers to the patient's atrial wall, to treat atrial fibrillation.

摘要翻译： 提供了一种用于将亚音速机械波传送到一个或多个所选患者区域的植入系统和方法，所述区域包括患者的心脏和/或肺。 输送机械波是为了治疗纤维性颤动或类似心律失常的目的，用于增强肺气体交换，增强心肌纤维松弛和增强冠状动脉灌注。 在约1,100,000Hz，优选1-50,000Hz的频率范围内产生机械波。 波浪可以连续递送短时间或长时间段，或者可以相对于患者的心跳信号的检测到的部分或响应于诸如原纤维化的检测到的事件在时间上进行控制。 在一个优选实施例中，可植入系统包括除颤电击发生器和通过首先递送一系列机械波然后递送电除颤电击来响应除颤事件的控制。 在另一个实施方案中，该系统和方法通过将预定时间的机械波输送给患者的心脏和/或肺来治疗初期纤维性颤动或心律失常。 在具体实施例中，机械波通过换能器阵列传送到患者的心房壁，以治疗房颤。

公开(公告)号：US06408205B1

公开(公告)日：2002-06-18

申请号：US09454966

申请日：1999-12-06

申请人： Alexis Renirie ,  Vincent Schouten ,  Koen Weijand

发明人： Alexis Renirie ,  Vincent Schouten ,  Koen Weijand

IPC分类号： A61N139

CPC分类号： A61N7/00 ,  A61B2017/00703 ,  A61N1/395 ,  A61N1/3956

摘要： There is provided an implanted system and method for delivering subsonic mechanical waves to one or more selected patient areas, said areas including the patient's heart and/or lungs. The mechanical waves are delivered for the purpose of treating fibrillation or like arrhythmias, for enhancing lung gas exchange, enhancing cardiac muscle fiber relaxation, and enhancing coronary perfusion. Mechanical waves are generated in a frequency range of about 1,100,000 Hz, and preferably 1-50,000 Hz. The waves may be delivered continuously for short or long time periods, or may be controlled in timing either with respect to detected portions of a patient's heartbeat signal or in response to a detected event such as fibrillation. In one preferred embodiment, the implantable system includes a defibrillation shock generator and control for responding to a defibrillation event by first delivering a sequence of mechanical waves and then delivering an electrical defibrillation shock. In another embodiment, the system and method treat incipient fibrillation or arrhythmia by delivering mechanical waves of predetermined timing to the patient's heart and/or lungs. In a specific embodiment, mechanical waves are delivered through an array of transducers to the patient's atrial wall, to treat atrial fibrillation.

摘要翻译： 提供了一种用于将亚音速机械波传送到一个或多个所选患者区域的植入系统和方法，所述区域包括患者的心脏和/或肺。 输送机械波是为了治疗纤维性颤动或类似心律失常的目的，用于增强肺气体交换，增强心肌纤维松弛和增强冠状动脉灌注。 在约1,100,000Hz，优选1-50,000Hz的频率范围内产生机械波。 波浪可以连续递送短时间或长时间段，或者可以相对于患者的心跳信号的检测到的部分或响应于诸如原纤维化的检测到的事件在时间上进行控制。 在一个优选实施例中，可植入系统包括除颤电击发生器和通过首先递送一系列机械波然后递送电除颤电击来响应除颤事件的控制。 在另一个实施方案中，该系统和方法通过将预定时间的机械波输送给患者的心脏和/或肺来治疗初期纤维性颤动或心律失常。 在具体实施例中，机械波通过换能器阵列传送到患者的心房壁，以治疗房颤。

公开(公告)号：US6110098A

公开(公告)日：2000-08-29

申请号：US769070

申请日：1996-12-18

申请人： Alexis Renirie ,  Vincent Schouten ,  Koen Weijand

发明人： Alexis Renirie ,  Vincent Schouten ,  Koen Weijand

IPC分类号： A61B17/00 ,  A61N1/39 ,  A61N7/00 ,  A61M1/12

CPC分类号： A61N7/00 ,  A61N1/3956 ,  A61B2017/00703 ,  A61N1/395

摘要： There is provided an implanted system and method for delivering subsonic mechanical waves to one or more selected patient areas, the areas including the patient's heart and/or lungs. The mechanical waves are delivered for the purpose of treating fibrillation or like arrhythmias, for enhancing lung gas exchange, enhancing cardiac muscle fiber relaxation, and enhancing coronary perfusion. Mechanical waves are generated in a frequency range of about 1-100,000 Hz, and preferably 1-50,000 Hz. The waves may be delivered continuously for short or long time periods, or may be controlled in timing either with respect to detected portions of a patient's heartbeat signal or in response to a detected event such as fibrillation. In one preferred embodiment, the implantable system includes a defibrillation shock generator and control for responding to a defibrillation event by first delivering a sequence of mechanical waves and then delivering an electrical defibrillation shock. In another embodiment, the system and method treat incipient fibrillation or arrhythmia by delivering mechanical waves of predetermined timing to the patient's heart and/or lungs. In a specific embodiment, mechanical waves are delivered through an array of transducers to the patient's atrial wall, to treat atrial fibrillation.

摘要翻译： 提供了一种用于将亚音速机械波传送到一个或多个所选患者区域的植入系统和方法，所述区域包括患者的心脏和/或肺。 输送机械波是为了治疗纤维性颤动或类似心律失常的目的，用于增强肺气体交换，增强心肌纤维松弛和增强冠状动脉灌注。 在约1-100,000Hz，优选1-50,000Hz的频率范围内产生机械波。 波浪可以连续递送短时间或长时间段，或者可以相对于患者的心跳信号的检测到的部分或响应于诸如原纤维化的检测到的事件在时间上进行控制。 在一个优选实施例中，可植入系统包括除颤电击发生器和通过首先递送一系列机械波然后递送电除颤电击来响应除颤事件的控制。 在另一个实施方案中，该系统和方法通过将预定时间的机械波输送给患者的心脏和/或肺来治疗初期纤维性颤动或心律失常。 在具体实施例中，机械波通过换能器阵列传送到患者的心房壁，以治疗房颤。