公开(公告)号：US20050085464A1

公开(公告)日：2005-04-21

申请号：US10918737

申请日：2004-08-16

申请人： Alfred Sapse ,  Janet Greeson

发明人： Alfred Sapse ,  Janet Greeson

IPC分类号： A61K31/70 ,  A61K31/551 ,  A61K31/24 ,  A61K31/315 ,  A61K31/375 ,  A61K31/513 ,  A61K31/522

CPC分类号： A61K31/70 ,  Y10S514/885 ,  Y10S514/974

摘要： The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated with anti-HIV drugs. The invention also relates to a method of treating the high cortisol catabolic effects of diseases such as AIDS in the HIV positive population and those with AIDS related complexes by the administration of a cortisol blocker. The present invention also discloses a composition comprising an anti-HIV drug and cortisol blocker. More specifically, the present invention relates to a cortisol blocking composition which comprises procaine, ascorbic acid and zinc heptahydrate.

摘要翻译： 本发明部分地基于以下发现：使用抗HIV药物与至少一种皮质醇阻滞剂如普鲁卡因组合减少与抗HIV药物相关的副作用。 本发明还涉及通过施用皮质醇阻滞剂来治疗HIV阳性人群中AIDS等疾病的高皮质醇分解代谢作用的方法。 本发明还公开了包含抗HIV药物和皮质醇阻滞剂的组合物。 更具体地说，本发明涉及含有普鲁卡因，抗坏血酸和七水合锌的皮质醇封闭组合物。