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1.发明授权Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human 失效抗HIV药物和抗皮质醇化合物的组合物以及降低人体抗HIV药物副作用的方法公开(公告)号：US07354906B2
公开(公告)日：2008-04-08
申请号：US10918737
申请日：2004-08-16
申请人： Alfred T. Sapse , Janet Greeson
发明人： Alfred T. Sapse , Janet Greeson
CPC分类号： A61K31/70 , Y10S514/885 , Y10S514/974
摘要： The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated with anti-HIV drugs. The invention also relates to a method of treating the high cortisol catabolic effects of diseases such as AIDS in the HIV positive population and those with AIDS related complexes by the administration of a cortisol blocker. The present invention also discloses a composition comprising an anti-HIV drug and cortisol blocker. More specifically, the present invention relates to a cortisol blocking composition which comprises procaine, ascorbic acid and zinc heptahydrate.
摘要翻译： 本发明部分地基于以下发现：使用抗HIV药物与至少一种皮质醇阻滞剂如普鲁卡因组合减少与抗HIV药物相关的副作用。 本发明还涉及通过施用皮质醇阻滞剂来治疗HIV阳性人群中AIDS等疾病的高皮质醇分解代谢作用的方法。 本发明还公开了包含抗HIV药物和皮质醇阻滞剂的组合物。 更具体地说，本发明涉及含有普鲁卡因，抗坏血酸和七水合锌的皮质醇封闭组合物。
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公开(公告)号：US20060247248A1
公开(公告)日：2006-11-02
申请号：US11347020
申请日：2006-02-03
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： A61K31/495 , A61K31/661 , A61K31/662 , A61K45/06 , C07D295/13 , A61K2300/00
摘要： A novel compound and method for preventing or treating neurodegenerative diseases by inhibiting acetylcholinesterase and binding the sigma-1 receptor are disclosed. Dimethylcarbamic acid 2,3-bis-dimethylcarbamoyloxy-6-[4-(4-ethyl-piperazin-yl)-butyryl]-phenyl ester and its derivatives represent a novel therapeutic strategy against β-amyloid peptide induced neurotoxicity, in inhibiting acetylcholinesterase, in improving cholinergic transmission, in binding the sigma-1 receptor, and in releasing a metabolite that is active both as a sigma-1 receptor ligand and an antioxidant.
摘要翻译： 公开了通过抑制乙酰胆碱酯酶和结合σ-1受体来预防或治疗神经变性疾病的新型化合物和方法。 二甲基氨基甲酸2,3-双 - 二甲基氨基甲酰氧基-6- [4-（4-乙基 - 哌嗪基） - 丁酰基] - 苯酯及其衍生物代表了β-淀粉样肽诱导的神经毒性的新型治疗策略，用于抑制乙酰胆碱酯酶， 改善胆碱能传递，结合σ-1受体，以及释放作为σ-1受体配体和抗氧化剂有活性的代谢物。
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公开(公告)号：US20060009433A1
公开(公告)日：2006-01-12
申请号：US11031538
申请日：2005-01-07
IPC分类号： A61K31/58
CPC分类号： A61K31/58
摘要： The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a disorder or disease related to, or the symptoms associated with a neurodegenerative disorder such as neurotoxicity or a neuropathology in a subject, particularly to beta-amyloid-induced neurotoxicity and Alzheimer's disease. The invention further provides a method for inducing stem cell differentiation into neuronal cells, by administering to the patient a therapeutically effective amount of a compound of the invention.
摘要翻译： 本发明涉及用于治疗，预防或降低发生与神经变性疾病相关的病症或疾病或与神经变性疾病如神经毒性或神经病理学相关的症状的风险的方法，试剂盒，组合和组合物，特别是 β-淀粉样蛋白诱导的神经毒性和阿尔茨海默病。 本发明还提供了通过向患者施用治疗有效量的本发明化合物来诱导干细胞分化成神经细胞的方法。
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公开(公告)号：US20100169987A1
公开(公告)日：2010-07-01
申请号：US12478957
申请日：2009-06-05
IPC分类号： G01N33/48 , A01K67/027
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/0312 , A61K49/0008
摘要： The present invention relates to the development of a pharmacological non-human animal model that associates memory loss to histopathological features found in the brain of a subject having Alzheimer's Disease. In one embodiment, a four-week continuous infusion of a Fe2+, Aβ42 and buthionine sulfoximine (FAB) solution in the left ventricle of young adult Long-Evans rats induced memory impairment accompanied by increased hyperphosphorylated Tau protein levels in cerebrospinal fluid. Brains from treated animals displayed neuritic plaques, tangles, neuronal loss, astrogliosis and microgliosis in hippocampus and cortex. The present invention may be utilized in evaluating preventive, therapeutic and diagnostic means for neurologic diseases.
摘要翻译： 本发明涉及药物非人动物模型的开发，其将记忆丧失与在具有阿尔茨海默病的受试者脑中发现的组织病理学特征相关联。 在一个实施方案中，在年轻成年的Long-Evans大鼠的左心室中连续输注一次Fe2 +，Aβ42和丁硫氨酸磺酰亚胺（FAB）四周，引起记忆障碍，伴随脑脊液中过度磷酸化的Tau蛋白水平升高。 治疗动物的大脑显示出海马和皮层神经炎斑块，缠结，神经元损失，星形胶质细胞增生和微胶质细胞增生。 本发明可用于评估神经疾病的预防，治疗和诊断手段。
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公开(公告)号：US20090286876A1
公开(公告)日：2009-11-19
申请号：US12269559
申请日：2008-11-12
IPC分类号： A61K31/24 , A61K31/166 , A61K31/164 , A61P25/28 , A61P25/02
CPC分类号： A61K31/135 , A61K31/16 , A61K31/165
摘要： The invention provides a therapeutic method for treating at least one symptom of a neurological disorder or disease such as Alzheimer's disease in a mammal, such as a human, wherein the toxicity of a pathogen of β amyloid peptide and/or glutamate in mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-arylamide or an (N-aminoalkyl)benzamide, including pharmaceutically acceptable salts thereof.
摘要翻译： 本发明提供在哺乳动物（例如人）中治疗至少一种神经障碍或疾病如阿尔茨海默病的症状的治疗方法，其中涉及哺乳动物细胞中β淀粉样肽和/或谷氨酸的病原体的毒性 并且期望抑制随后诱导的病理学途径，包括向需要这种治疗的哺乳动物施用有效量的N-芳基酰胺或（N-氨基烷基）苯甲酰胺，包括其药学上可接受的盐。
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公开(公告)号：US20060194815A1
公开(公告)日：2006-08-31
申请号：US11293866
申请日：2005-12-02
申请人： Laurent Lecanu , Janet Greeson , Vassilios Papadopoulos , Jing Xu
发明人： Laurent Lecanu , Janet Greeson , Vassilios Papadopoulos , Jing Xu
IPC分类号： A61K31/496
CPC分类号： A61K31/497 , A61K31/33 , A61K31/496
摘要： The present invention relates to cortisol-modulating compounds, including but not limited to benzamide and benzoic acid derivatives such as procaine and procaine derivatives, utilized in compositions and methods for treating cortisol-mediated disorders, including but not limited to age-related depression, hypertension, Alzheimer's disease, and acquired immunodeficiency syndrome.
摘要翻译： 本发明涉及皮质醇调节化合物，包括但不限于苯甲酰胺和苯甲酸衍生物如普鲁卡因和普鲁卡因衍生物，用于治疗皮质醇介导的病症的组合物和方法，包括但不限于与年龄有关的抑郁症，高血压 ，阿尔茨海默病和获得性免疫缺陷综合征。
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公开(公告)号：US20060194814A1
公开(公告)日：2006-08-31
申请号：US11292797
申请日：2005-12-02
IPC分类号： A61K31/496
CPC分类号： A61K31/496
摘要： The invention provides a therapeutic method for preventing or treating a pathological condition or symptom in a mammal, such as a human, wherein the infectivity of a pathogen such as a retrovirus toward mammalian cells is implicated and inhibition of its infectivity is desired comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof that inhibits pathogenic infectivity, including pharmaceutically acceptable salts thereof. The invention also provides a therapeutic method for preventing or treating a neuropathological condition or symptom in a mammal, such as human, comprising administering to a mammal in need of such therapy, an effective amount of an N-benzamide derivative of a piperazinyl amide of an amino acid thereof, including pharmaceutically acceptable salts thereof.
摘要翻译： 本发明提供了预防或治疗哺乳动物（例如人）中的病理状况或症状的治疗方法，其中牵涉到病原体如逆转录病毒对哺乳动物细胞的感染性，并且希望抑制其感染性，包括给予 需要这种治疗的哺乳动物，有效量的抑制病原性感染性的氨基酸的哌嗪基酰胺的N-苯甲酰胺衍生物，包括其药学上可接受的盐。 本发明还提供了用于预防或治疗哺乳动物（例如人）的神经病理学病症或症状的治疗方法，其包括对需要这种治疗的哺乳动物施用有效量的哌嗪基酰胺的N-苯甲酰胺衍生物 其氨基酸，包括其药学上可接受的盐。
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8.发明申请Composition of anti-HIV drugs and anti-cortisol compounds and method for decreasing the side effects of anti-HIV drugs in a human 失效抗HIV药物和抗皮质醇化合物的组合物以及降低人体抗HIV药物副作用的方法公开(公告)号：US20050085464A1
公开(公告)日：2005-04-21
申请号：US10918737
申请日：2004-08-16
申请人： Alfred Sapse , Janet Greeson
发明人： Alfred Sapse , Janet Greeson
IPC分类号： A61K31/70 , A61K31/551 , A61K31/24 , A61K31/315 , A61K31/375 , A61K31/513 , A61K31/522
CPC分类号： A61K31/70 , Y10S514/885 , Y10S514/974
摘要： The present invention is based, in part, upon the discovery that the use of an anti-HIV drug in combination with at least one cortisol blocker such as procaine, reduces the side effects associated with anti-HIV drugs. The invention also relates to a method of treating the high cortisol catabolic effects of diseases such as AIDS in the HIV positive population and those with AIDS related complexes by the administration of a cortisol blocker. The present invention also discloses a composition comprising an anti-HIV drug and cortisol blocker. More specifically, the present invention relates to a cortisol blocking composition which comprises procaine, ascorbic acid and zinc heptahydrate.
摘要翻译： 本发明部分地基于以下发现：使用抗HIV药物与至少一种皮质醇阻滞剂如普鲁卡因组合减少与抗HIV药物相关的副作用。 本发明还涉及通过施用皮质醇阻滞剂来治疗HIV阳性人群中AIDS等疾病的高皮质醇分解代谢作用的方法。 本发明还公开了包含抗HIV药物和皮质醇阻滞剂的组合物。 更具体地说，本发明涉及含有普鲁卡因，抗坏血酸和七水合锌的皮质醇封闭组合物。
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9.发明申请Use of (4-Alkylpiperazinyl)(phenyl) methanones in the treatment of alzheimer's disease 审中-公开（4-烷基哌嗪基）（苯基）甲酮在治疗阿尔茨海默病中的应用公开(公告)号：US20090197891A1
公开(公告)日：2009-08-06
申请号：US10599952
申请日：2005-04-12
IPC分类号： A61K31/495 , C12N5/06
CPC分类号： C07D295/192 , A61K31/495
摘要： The invention provides a therapeutic method for treating at least one symptom of Alzheimer's disease in a mammal, such as a human, wherein the toxicity of a pathogen of β amyloid peptide mammalian cells is implicated and inhibition of the subsequently-induced pathological pathways is desired comprising administering to a mammal in need of such therapy, an effective amount of a benzoylpiperazine derivative, including pharmaceutically acceptable salts thereof.
摘要翻译： 本发明提供了治疗哺乳动物（例如人）中的阿尔茨海默病的至少一种症状的治疗方法，其中涉及β淀粉样蛋白肽哺乳动物细胞的病原体的毒性，并期望抑制随后诱导的病理学途径，包括 对需要这种治疗的哺乳动物施用有效量的苯甲酰基哌嗪衍生物，包括其药学上可接受的盐。
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公开(公告)号：US20090176802A1
公开(公告)日：2009-07-09
申请号：US12182845
申请日：2008-07-30
IPC分类号： A61K31/496
CPC分类号： C07D295/13 , A61K31/496
摘要： A novel method for treating a mammal exposed to an exogenous neurotoxic agent is disclosed.
摘要翻译： 公开了一种用于治疗暴露于外源性神经毒性试剂的哺乳动物的新方法。
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