公开(公告)号：US20240352464A1

公开(公告)日：2024-10-24

申请号：US18599052

申请日：2024-03-07

申请人： Aligos Therapeutics, Inc. ,  Merck Sharp & Dohme LLC

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Xuan Luong ,  Kellan Passow ,  Aneerban Bhattacharya ,  Saul Martinez Montero ,  Jerome Deval

IPC分类号： C12N15/113

CPC分类号： C12N15/1137 ,  C12Y101/01062 ,  C12N2310/14

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising additional modification including a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap. The siNA molecules may reduce or inhibit the production of hydroxysteroid dehydrogenase.

公开(公告)号：US20230365970A1

公开(公告)日：2023-11-16

申请号：US18361363

申请日：2023-07-28

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20 ,  C12N2310/351 ,  C12N2310/315 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/322

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US11549110B2

公开(公告)日：2023-01-10

申请号：US17672268

申请日：2022-02-15

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC分类号： C12N15/113 ,  A61P31/20 ,  A61K31/713 ,  A61K45/06

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20210189392A1

公开(公告)日：2021-06-24

申请号：US17117494

申请日：2020-12-10

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Rajendra Pandey ,  Vivek Kumar Rajwanshi ,  David Bernard Smith ,  Lawrence M. Blatt ,  Jin Hong ,  Megan Elizabeth Fitzgerald

IPC分类号： C12N15/113

摘要： Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is an EC50 that is less than 100 nM.

公开(公告)号：US12129469B2

公开(公告)日：2024-10-29

申请号：US18361363

申请日：2023-07-28

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/3231 ,  C12N2310/351 ,  C12N2320/31

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20230332153A1

公开(公告)日：2023-10-19

申请号：US18059561

申请日：2022-11-29

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC分类号： C12N15/113 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61K31/713 ,  A61K45/06 ,  A61P31/20 ,  C12N2310/351 ,  C12N2310/315 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2310/321 ,  C12N2310/3231 ,  C12N2310/322

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US20220364096A1

公开(公告)日：2022-11-17

申请号：US17194079

申请日：2021-03-05

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Markus Hossbach ,  Rajendra K. Pandey ,  Jin Hong ,  Laxman Eltepu ,  Saul Martinez Montero ,  N. Tilani S. De Costa

IPC分类号： C12N15/113 ,  A61K45/06 ,  A61K31/713 ,  A61P31/20

摘要： Disclosed herein are short interfering nucleic acid (siNA) molecules comprising modified nucleotides and uses thereof. The siNA molecules may be double stranded and comprise modified nucleotides selected from 2′-O-methyl nucleotides and 2′-fluoro nucleotides. Further disclosed herein are siNA molecules comprising (a) a phosphorylation blocker, conjugated moiety, or 5′-stabilized end cap; and (b) a short interfering nucleic acid (siNA).

公开(公告)号：US11466274B2

公开(公告)日：2022-10-11

申请号：US16887063

申请日：2020-05-29

申请人： Aligos Therapeutics, Inc.

发明人： Leonid Beigelman ,  Rajendra K. Pandey ,  Vivek Kumar Rajwanshi ,  David Bernard Smith ,  Jin Hong

IPC分类号： C12N15/11 ,  C12N15/113 ,  A61P31/20 ,  A61K31/7125

摘要： The disclosure includes antisense oligonucleotides, including gapmer antisense oligonucleotides, along with methods of making and use, e.g., against HBV.

公开(公告)号：US20230383296A1

公开(公告)日：2023-11-30

申请号：US18122433

申请日：2023-03-16

申请人： ALIGOS THERAPEUTICS, INC.

发明人： Leonid Beigelman ,  Vivek Kumar Rajwanshi ,  Laxman Eltepu ,  Saul Martinez Montero ,  Jin Hong

IPC分类号： C12N15/113 ,  A61P31/20

CPC分类号： C12N15/1131 ,  A61P31/20 ,  C12N15/1137 ,  C12N15/1136 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/314 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2320/32 ,  C12N2320/51 ,  C12N2320/53 ,  C12N2310/351

摘要： The disclosure includes antisense oligonucleotides (ASOs), including gapmer ASOs, and methods of making and using the same.

公开(公告)号：US11166976B2

公开(公告)日：2021-11-09

申请号：US17018822

申请日：2020-09-11

申请人： ALIGOS THERAPEUTICS, INC.

发明人： Leonid Beigelman ,  Rajendra Pandey ,  Vivek Kumar Rajwanshi ,  David Bernard Smith ,  Lawrence M. Blatt ,  Jin Hong

IPC分类号： A61K31/7125 ,  A61K9/00 ,  A61P31/20 ,  C12N15/113 ,  C07H21/02

摘要： Various embodiments provide STOPS™ polymers that are S-antigen transport inhibiting oligonucleotide polymers, processes for making them and methods of using them to treat diseases and conditions. In some embodiments the STOPS™ modified oligonucleotides include an at least partially phosphorothioated sequence of alternating A and C units having modifications as described herein. The sequence independent antiviral activity against hepatitis B of embodiments of STOPS™ modified oligonucleotides, as determined by HBsAg Secretion Assay, is greater than that of a reference compound.