公开(公告)号：US07749700B2

公开(公告)日：2010-07-06

申请号：US11155835

申请日：2005-06-17

申请人： Alison E. Baird ,  David F. Moore ,  Ehud Goldin

发明人： Alison E. Baird ,  David F. Moore ,  Ehud Goldin

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

摘要： Methods are provided for evaluating a stroke, for example for determining whether a subject has had an ischemic stroke, determining the severity or likely neurological recovery of a subject who has had an ischemic stroke, and determining a treatment regimen for a subject who has had an ischemic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression in ischemic stroke related genes (or proteins), such as white blood cell activation and differentiation genes (or proteins), genes (or proteins) related to hypoxia, genes (or proteins) involved in vascular repair, and genes (or proteins) related to a specific peripheral blood mononuclear cell (PBMC) response to the altered cerebral microenvironment. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of an ischemic stroke-related molecule.

摘要翻译： 提供了用于评估中风的方法，例如用于确定受试者是否具有缺血性中风，确定患有缺血性中风的受试者的严重性或可能的神经恢复，以及确定已经具有缺血性卒中的受试者的治疗方案 缺血性中风，以及可用于实施该方法的阵列和试剂盒。 在具体实例中，该方法包括筛选缺血性卒中相关基因（或蛋白质）中的表达，例如白血细胞活化和分化基因（或蛋白质），与缺氧有关的基因（或蛋白质），参与的基因（或蛋白质） 血管修复和与特异性外周血单核细胞（PBMC）相关的基因（或蛋白质）对改变的脑微环境的反应。 还提供了鉴定改变缺血性卒中相关分子的活性（例如表达）的一种或多种试剂的方法。

公开(公告)号：US20100086481A1

公开(公告)日：2010-04-08

申请号：US12307910

申请日：2007-07-11

申请人： Alison E. Baird ,  David F. Moore ,  Ehud Goldin ,  Kory Johnson

发明人： Alison E. Baird ,  David F. Moore ,  Ehud Goldin ,  Kory Johnson

IPC分类号： C12Q1/68 ,  C40B40/06 ,  C40B40/10 ,  A61K49/00

CPC分类号： C12Q1/6883 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158

摘要： Methods are provided for evaluating a stroke, for example for determining whether a subject has had a hemorrhagic stroke, determining the severity or likely neurological recovery of a subject who has had a hemorrhagic stroke, and determining a treatment regimen for a subject who has had a hemorrhagic stroke, as are arrays and kits that can be used to practice the methods. In particular examples, the method includes screening for expression of hemorrhagic stroke related genes (or proteins), such as genes (or proteins) involved in suppression of the immune response, genes (or proteins) involved in vascular repair, genes (or proteins) involved in the acute inflammatory response, genes (or proteins) involved in cell adhesion, genes (or proteins) involved in hypoxia, genes (or proteins) involved in signal transduction, and genes (or proteins) involved in the response to the altered cerebral microenvironment. Arrays and kits are provided that can be used in the disclosed methods. Also provided are methods of identifying one or more agents that alter the activity (such as the expression) of a hemorrhagic stroke-related molecule.

摘要翻译： 提供了用于评估中风的方法，例如用于确定受试者是否具有出血性中风，确定具有出血性中风的受试者的严重性或可能的神经系统恢复，以及确定具有出血性中风的受试者的治疗方案 出血性中风，以及可用于实践方法的数组和试剂盒。 在具体实例中，该方法包括筛选出血性中风相关基因（或蛋白质）的表达，例如涉及免疫应答的基因（或蛋白质），参与血管修复的基因（或蛋白质），基因（或蛋白质） 参与急性炎症反应，参与细胞粘附的基因（或蛋白质），涉及缺氧的基因（或蛋白质），参与信号转导的基因（或蛋白质）以及参与改变的大脑的反应的基因（或蛋白质） 微环境。 提供了可以在所公开的方法中使用的阵列和试剂盒。 还提供了鉴定改变出血性中风相关分子的活性（例如表达）的一种或多种试剂的方法。