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1.发明申请公开(公告)号：US20120065187A1
公开(公告)日：2012-03-15
申请号：US13301131
申请日：2011-11-21
申请人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
发明人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
IPC分类号： A61K31/4985 , A61K31/55 , A61K31/551 , A61K31/5415 , A61P11/06 , A61P37/00 , A61P37/08 , A61P27/02 , A61P17/04 , A61P17/00 , C07D487/04 , A61P29/00
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译： 本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。
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2.发明申请AMINOPYRIMIDINE INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE 审中-公开用于治疗疾病的组胺受体的氨基嘧啶抑制剂公开(公告)号：US20100063047A1
公开(公告)日：2010-03-11
申请号：US12556842
申请日：2009-09-10
IPC分类号： A61K31/5377 , C07D495/04 , A61K31/497 , A61K31/519 , A61K31/4365
CPC分类号： C07D495/04 , A61K9/0043 , A61K9/0048 , A61K9/0073 , A61K31/4365 , A61K31/497 , A61K31/519 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译： 本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。
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3.发明申请公开(公告)号：US20100120741A1
公开(公告)日：2010-05-13
申请号：US12556866
申请日：2009-09-10
申请人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
发明人： Allen J. Borchardt , Clay Beauregard , Travis Cook , Robert L. Davis , Daniel A. Gamache , John M. Yanni
IPC分类号： A61K31/397 , A61P11/06 , A61K31/55 , A61K31/551 , A61K31/4985 , C07D487/04 , A61P19/02
CPC分类号： C07D487/04 , C07D471/04 , C07D498/04 , C07D519/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.
摘要翻译： 本发明涉及可用作H1R和/或H4R抑制剂用于治疗或预防炎性，自身免疫性，过敏性和眼部疾病的化合物和方法。
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公开(公告)号：US20100081646A1
公开(公告)日：2010-04-01
申请号：US12544185
申请日：2009-08-19
申请人： Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
发明人： Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
IPC分类号： A61K31/551 , C07D401/12 , C07D413/14 , C07D401/14 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61P27/02 , A61P37/00
CPC分类号： A61K31/4704 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PDE4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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5.发明申请Use of an Inhibitor of TNFa Plus an Antihistamine to Treat Allergic Rhinitis and Allergic Conjunctivitis 审中-公开使用抑制TNFa Plus抗组胺药治疗过敏性鼻炎和过敏性结膜炎公开(公告)号：US20080254029A1
公开(公告)日：2008-10-16
申请号：US12100715
申请日：2008-04-10
IPC分类号： A61K39/395 , A61K31/551 , A61K31/335 , A61K31/55 , A61P37/08 , A61K38/16 , A61K31/4353 , A61K31/52
CPC分类号： A61K45/06 , A61K31/335 , A61K31/551 , A61K38/191 , A61K39/395 , A61K2300/00
摘要： Disclosed are methods of treating allergic conjunctivitis and allergic rhinitis in a subject that involve topically administering to the subject a composition comprising a pharmaceutically effective amount of an H1 antagonist and an anti-TNFα compound.
摘要翻译： 公开了治疗过敏性结膜炎和过敏性鼻炎的方法，其涉及向受试者局部施用包含药学有效量的H 1拮抗剂和抗TNFα化合物的组合物。
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公开(公告)号：US20120015953A1
公开(公告)日：2012-01-19
申请号：US13183194
申请日：2011-07-14
IPC分类号： A61K31/4985 , C12Q1/28 , A61P27/14 , A61K31/335 , A61K31/519
CPC分类号： A61K31/335 , A61K9/0048 , A61K31/4985 , A61K31/519 , A61K45/06 , C07D487/04 , A61K2300/00
摘要： The present invention relates to compositions comprising an antagonist of the histamine H1 receptor and a compatible antagonist of the histamine H4 receptor. The antagonist compounds are selected to prevent the H4 receptor antagonist from interfering with the H1 receptor antagonist's suppression of acute phase allergic responses in a patient. The present invention also relates to compositions comprising a mast cell stabilizer and a compatible antagonist of the histamine H4 receptor.
摘要翻译： 本发明涉及包含组胺H1受体的拮抗剂和组胺H 4受体的相容拮抗剂的组合物。 选择拮抗剂化合物以防止H4受体拮抗剂干扰H1受体拮抗剂抑制患者的急性期过敏反应。 本发明还涉及包含肥大细胞稳定剂和组胺H 4受体的相容拮抗剂的组合物。
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公开(公告)号：US20130045975A1
公开(公告)日：2013-02-21
申请号：US13370756
申请日：2012-02-10
申请人： Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
发明人： Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
IPC分类号： A61K31/4709 , C07D401/14 , A61K31/496 , C07D413/14 , A61K31/5377 , A61K31/551 , A61P27/02 , A61P27/14 , A61P27/04 , A61P27/06 , A61P29/00 , A61P9/10 , A61P25/00 , A61P37/08 , C07D401/12
CPC分类号： A61K31/4704 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
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公开(公告)号：US08138205B2
公开(公告)日：2012-03-20
申请号：US12544185
申请日：2009-08-19
申请人： Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
发明人： Steven P. Govek , Clay Beauregard , Daniel A. Gamache , Mark R. Hellberg , Stewart A. Noble , Andrew K. Shiau , David J. Thomas , John M. Yanni
IPC分类号： A61K31/47 , C07D401/12
CPC分类号： A61K31/4704 , A61K31/4709 , A61K31/497 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D401/12 , A61K2300/00
摘要： The present invention relates to compounds and methods which may be useful as inhibitors of phosphodiesterase 4 (PDE4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
摘要翻译： 本发明涉及可用作磷酸二酯酶4（PDE4）抑制剂的化合物和方法，用于治疗或预防炎性疾病和涉及升高的细胞因子和促炎介质水平的其它疾病。
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9.发明申请USE OF A COMBINATION OF OLOPATADINE AND CILOMILAST TO TREAT NON-INFECTIOUS RHINITIS AND ALLERGIC CONJUNCTIVITIS 审中-公开使用奥帕他汀和青光眼联合治疗非感染性RHINITIS和过度连续性公开(公告)号：US20090182035A1
公开(公告)日：2009-07-16
申请号：US12406755
申请日：2009-03-18
IPC分类号： A61K31/335
CPC分类号： A61K38/191 , A61K9/0043 , A61K9/0048 , A61K31/275 , A61K31/335 , A61K31/551 , A61K39/395 , A61K45/06 , A61K2300/00
摘要： Disclosed are methods of treating allergic conjunctivitis and non-infectious rhinitis in a subject that involve topically administering to the subject a composition comprising olopatadine and cilomilast.
摘要翻译： 公开了在受试者中治疗过敏性结膜炎和非感染性鼻炎的方法，其涉及向受试者局部施用包含奥洛他定和西洛司特的组合物。
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10.发明申请RNAi-Mediated Inhibition of Spleen Tyrosine Kinase-Related Inflammatory Conditions 有权RNAi介导的脾脏酪氨酸激酶相关炎症病症的抑制公开(公告)号：US20110288157A1
公开(公告)日：2011-11-24
申请号：US13172964
申请日：2011-06-30
IPC分类号： A61K31/7105 , A61P27/02 , A61K31/713 , A61P29/00
CPC分类号： C12N15/1137 , A61K31/7105 , A61K31/713 , C07H21/02 , C12N15/113 , C12N2310/14 , C12N2310/531 , C12N2320/30
摘要： RNA interference is provided for inhibition of spleen tyrosine kinase (Syk) mRNA expression, in particular, for treating patients having a Syk-related inflammatory condition or at risk of developing a Syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease.
摘要翻译： 提供RNA干扰用于抑制脾脏酪氨酸激酶（Syk）mRNA表达，特别是用于治疗患有Syk相关炎性病症的患者或具有发展Syk相关炎性病症如过敏性结膜炎，眼部炎症，皮炎， 鼻炎，哮喘，过敏或肥大细胞疾病。
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