公开(公告)号：US20160361338A1

公开(公告)日：2016-12-15

申请号：US15121412

申请日：2014-03-14

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan ,  Alexandros Yiannikouris

IPC: A61K31/7076

CPC classification number: A61K31/7135 ,  A61K31/28 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/05 ,  A61K38/28 ,  C07D473/34

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of formula (I), formula (II), a compound of formula (III) and combinations thereof, and methods of using the same in enhancing mitochondrial function, or treating mitochondrial dysfunction.

Abstract translation: 本申请涉及包含硒化合物如5'-甲基硒腺苷，Se-腺苷-L-高半胱氨酸，γ-谷氨酰 - 甲基硒代半胱氨酸，式（I），式（II）的化合物，式 （III）及其组合，以及使用其提高线粒体功能或治疗线粒体功能障碍的方法。

公开(公告)号：US11014954B2

公开(公告)日：2021-05-25

申请号：US16490836

申请日：2018-05-01

Applicant: Alltech, Inc.

Inventor： Zi-Jian Lan ,  Ronan Power ,  Alexandros Yiannikouris ,  Thirupathi Reddy Yerramreddy

IPC: C07H19/16 ,  C07H19/167 ,  A61P3/10

Abstract: The present disclosure provides compounds of formulas (1)-(3), and compositions and methods of use thereof. The present disclosure also provides methods of preparing a provided compound and composition, and methods of characterizing a provided compound and composition.

公开(公告)号：US10201559B2

公开(公告)日：2019-02-12

申请号：US15121412

申请日：2014-03-14

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan ,  Alexandros Yiannikouris

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7135 ,  A61K31/7076 ,  C07D473/34 ,  A61K31/28 ,  A61K38/05 ,  A61K38/28 ,  A61K31/706 ,  A61K31/7064

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of formula (I), formula (II), a compound of formula (III) and combinations thereof, and methods of using the same in enhancing mitochondrial function, or treating mitochondrial dysfunction.

公开(公告)号：US11613552B2

公开(公告)日：2023-03-28

申请号：US17238354

申请日：2021-04-23

Applicant: Alltech, Inc.

Inventor： Zi-Jian Lan ,  Ronan Power ,  Alexandros Yiannikouris ,  Thirupathi Reddy Yerramreddy

IPC: A61K31/7076 ,  C07H19/16 ,  A61P3/10 ,  C07H19/167

Abstract: The present disclosure provides compounds of formulas (1)-(3), and compositions and methods of use thereof. The present disclosure also provides methods of preparing a provided compound and composition, and methods of characterizing a provided compound and composition.

公开(公告)号：US10201558B2

公开(公告)日：2019-02-12

申请号：US14855065

申请日：2015-09-15

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan

IPC: A61K31/28 ,  A61K38/05 ,  A61K38/28 ,  C07D473/34 ,  A61K31/7076 ,  A61K31/7135 ,  A61K31/706 ,  A61K31/7064

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, a compound of Formula (I), and combinations thereof, and methods of using the same for inhibiting β amyloid aggregation, ApoE4 expression, p38 or Tau protein phosphorylation, or increasing Neprilysin and Insulin Degrading Enzyme expression.

公开(公告)号：US20210238216A1

公开(公告)日：2021-08-05

申请号：US17238354

申请日：2021-04-23

Applicant: Alltech, Inc.

Inventor： Zi-Jian Lan ,  Ronan Power ,  Alexandros Yiannikouris ,  Thirupathi Reddy Yerramreddy

IPC: C07H19/16 ,  A61P3/10 ,  C07H19/167

Abstract: The present disclosure provides compounds of formulas (1)-(3), and compositions and methods of use thereof. The present disclosure also provides methods of preparing a provided compound and composition, and methods of characterizing a provided compound and composition.

公开(公告)号：US09642874B2

公开(公告)日：2017-05-09

申请号：US14855128

申请日：2015-09-15

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan

IPC: A61K31/7076 ,  A61K38/05 ,  A61K31/7135 ,  A61K31/28 ,  A61K38/28

CPC classification number: A61K31/7135 ,  A61K31/28 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/05 ,  A61K38/28 ,  C07D473/34

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of Formula (I), Formula (II), or Formula (III), and combinations thereof, and methods of using the same for modulating glucose metabolism in a subject.

公开(公告)号：US20160082033A1

公开(公告)日：2016-03-24

申请号：US14855065

申请日：2015-09-15

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan

IPC: A61K31/7076

CPC classification number: A61K31/7135 ,  A61K31/28 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/05 ,  A61K38/28 ,  C07D473/34

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, a compound of Formula (I), and combinations thereof, and methods of using the same for inhibiting β amyloid aggregation, ApoE4 expression, p38 or Tau protein phosphorylation, or increasing Neprilysin and Insulin Degrading Enzyme expression.

Abstract translation: 本申请涉及包含硒化合物的组合物，例如5'-甲基硒腺嘌呤，式（I）化合物及其组合，以及其用于抑制β-葡聚糖的方法。 淀粉样蛋白聚集，ApoE4表达，p38或Tau蛋白磷酸化，或增加Neprilysin和胰岛素降解酶表达。

公开(公告)号：US20160045533A1

公开(公告)日：2016-02-18

申请号：US14855128

申请日：2015-09-15

Applicant: Alltech, Inc.

Inventor： Ronan Power ,  Zi-Jian Lan

IPC: A61K31/7135 ,  A61K31/28 ,  A61K38/28 ,  A61K31/7076

CPC classification number: A61K31/7135 ,  A61K31/28 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  A61K38/05 ,  A61K38/28 ,  C07D473/34

Abstract: The present application relates to compositions comprising selenium compounds, such as 5′-Methylselenoadenosine, Se-Adenosyl-L-homocysteine, Gamma-glutamyl-methylseleno-cysteine, a compound of Formula (I), Formula (II), or Formula (III), and combinations thereof, and methods of using the same for modulating glucose metabolism in a subject.