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公开(公告)号：US20160375011A1
公开(公告)日：2016-12-29
申请号：US15262420
申请日：2016-09-12
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
IPC分类号： A61K31/485
CPC分类号： A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/185 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。
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2.发明申请公开(公告)号：US20150024058A1
公开(公告)日：2015-01-22
申请号：US14503781
申请日：2014-10-01
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
IPC分类号： A61K9/50 , A61K31/485
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。
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公开(公告)号：US20130337020A1
公开(公告)日：2013-12-19
申请号：US13971969
申请日：2013-08-21
发明人： Frank Matthews , Alfred C Liang , Frank Johnson
IPC分类号： A61K9/00
CPC分类号： A61K9/5047 , A61K9/00 , A61K9/2081 , A61K9/2086 , A61K9/209 , A61K9/5026 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Provided herein is a method of treating a condition in a host that is responsive to an agonist, the method comprising administering to the host a multi-layer pharmaceutical composition comprising the agonist and an antagonist thereof, wherein the agonist and antagonist are not in direct contact with one another in the intact form of the composition.
摘要翻译： 本文提供了一种治疗宿主中对激动剂有反应的病症的方法，该方法包括向宿主施用包含激动剂及其拮抗剂的多层药物组合物，其中激动剂和拮抗剂不直接接触 彼此以组合物的完整形式。
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公开(公告)号：US20130122065A1
公开(公告)日：2013-05-16
申请号：US13735523
申请日：2013-01-07
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
IPC分类号： A61K9/00
CPC分类号： A61K31/485 , A61K9/0002 , A61K9/4808 , A61K9/5026 , A61K9/5078
摘要： Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.
摘要翻译： 本文提供的药物组合物包含拮抗剂，激动剂，密封剂涂层和螯合聚合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 层将拮抗剂与激动剂彼此物理分离。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。
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公开(公告)号：US20160338968A1
公开(公告)日：2016-11-24
申请号：US15224818
申请日：2016-08-01
发明人： Frank Matthews , Alfred C. Liang , Frank Johnson
IPC分类号： A61K9/50 , A61K31/485
CPC分类号： A61K9/5047 , A61K9/00 , A61K9/2081 , A61K9/2086 , A61K9/209 , A61K9/5026 , A61K9/5073 , A61K9/5078 , A61K9/5084 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Provided herein is a method of treating a condition in a host that is responsive to an agonist, the method comprising administering to the host a multi-layer pharmaceutical composition comprising the agonist and an antagonist thereof, wherein the agonist and antagonist are not in direct contact with one another in the intact form of the composition.
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公开(公告)号：US20140037721A1
公开(公告)日：2014-02-06
申请号：US14050861
申请日：2013-10-10
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
IPC分类号： A61K31/485 , A61K9/48
CPC分类号： A61K31/485 , A61K9/0002 , A61K9/4808 , A61K9/5026 , A61K9/5078
摘要： Provided herein are pharmaceutical compositions comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions are also demonstrated.
摘要翻译： 本文提供的药物组合物包含拮抗剂，激动剂，密封涂层和螯合聚合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 层将拮抗剂与激动剂彼此物理分离。 还提供了制备这种药物组合物的方法。 还证明了使用这种组合物治疗疼痛的方法。
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公开(公告)号：US20190314289A1
公开(公告)日：2019-10-17
申请号：US15876589
申请日：2018-01-22
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
IPC分类号： A61K9/50 , A61K9/16 , A61K9/48 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
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8.发明申请公开(公告)号：US20170056329A1
公开(公告)日：2017-03-02
申请号：US15145717
申请日：2016-05-03
发明人： Frank Matthews , Garth Boehm , Lijuan Tang , Alfred Liang
IPC分类号： A61K9/50 , A61K31/485
CPC分类号： A61K9/5078 , A61K9/16 , A61K9/167 , A61K9/1676 , A61K9/4808 , A61K9/50 , A61K9/5015 , A61K9/5026 , A61K9/5073 , A61K31/485
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided.
摘要翻译： 本文提供了包含拮抗剂，激动剂，密封涂层和螯合聚合物的药物组合物，其中所述拮抗剂，激动剂，密封剂涂层和至少一种螯合聚合物都是单一单元的组分，并且其中所述密封涂层形成 将拮抗剂与激动剂彼此物理分离的层。 还提供了制备这种药物组合物的方法。
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公开(公告)号：US20160058755A1
公开(公告)日：2016-03-03
申请号：US14933407
申请日：2015-11-05
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
IPC分类号： A61K31/485 , A61K9/16 , A61K31/185
CPC分类号： A61K9/1652 , A61K9/5026 , A61K9/5047 , A61K9/5078 , A61K9/5084 , A61K31/185 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Provided herein is a pharmaceutical composition comprising an antagonist, an agonist, a seal coat, and a sequestering polymer, wherein the antagonist, agonist, seal coat and at least one sequestering polymer are all components of a single unit, and wherein the seal coat forms a layer physically separating the antagonist from the agonist from one another. Methods for manufacturing such a pharmaceutical composition are also provided. Methods for treating pain using such compositions is also demonstrated.
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公开(公告)号：US20150104519A1
公开(公告)日：2015-04-16
申请号：US14578574
申请日：2014-12-22
发明人： Alfred Liang , Frank Matthews , Garth Boehm , Lijuan Tang , Frank Johnson , Joseph Stauffer
IPC分类号： A61K9/16 , A61K31/485
CPC分类号： A61K9/16 , A61K9/5078 , A61K31/485 , A61K2300/00
摘要： Provided herein are formulations and methods for treating pain in human beings. Also provided are optimal ratios at which an opioid and an opioid antagonist may be combined for administration to humans such that the opioid activity is inhibited. These ratios may also be used to formulate compositions containing both an opioid and an opioid antagonist within a single pharmaceutical dosing unit.
摘要翻译： 本文提供了用于治疗人类疼痛的制剂和方法。 还提供了阿片样物质和阿片样物质拮抗剂可以组合用于给予人类以使阿片样物质活性受到抑制的最佳比例。 这些比例也可用于在单个药物给药单元内配制含有阿片样物质和阿片样物质拮抗剂的组合物。
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