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公开(公告)号:US20220313614A1
公开(公告)日:2022-10-06
申请号:US17223746
申请日:2021-04-06
Applicant: Altria Client Services LLC
Inventor: Feng GAO , Benjamin L. RAGLAND , David J. PHILLIPS , Rebecca M. GRAY , Pauline MARCQ , Christian SCHUH , Krasnodara N. CAMERON
IPC: A61K9/50 , A61K9/00 , A61K31/465 , A61K47/26
Abstract: A method for forming encapsulated nicotine granules (ENGs) includes heating a first mixture to form a molten mixture, the first mixture includes one or more polyols; cooling the molten mixture to a first temperature to form a cooled molten mixture; adding at least one of nicotine and one or more nicotine salts to the cooled molten mixture to form a second mixture; cooling the second mixture to a second temperature to form one or more solidified structures, where the second temperature is different from the first temperature; and fragmenting the one or more solidified structures so as to form a plurality of encapsulated nicotine granules. The first temperature may be between about 120° C. and about 200° C. The second temperature may be below a glass transition temperature (Tg) of the one or more polyols. For example, the second temperature may be between about 65° C. and about 200° C.
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公开(公告)号:US20220313678A1
公开(公告)日:2022-10-06
申请号:US17223756
申请日:2021-04-06
Applicant: Altria Client Services LLC
Inventor: David J. PHILLIPS , Rebecca M. GRAY , Munmaya MISHRA , Shuzhong ZHUANG
IPC: A61K31/465 , A61K9/16 , A24B13/00 , A24B15/16
Abstract: A method for preparing the nicotine-containing powder includes dissolving a carrier in a solvent to form a first solution, where the carrier includes a biopolymer, a natural polymer, a synthetic polymer, a bulk sweetener, or any combination thereof; contacting the first solution with nicotine, a nicotine complex, a nicotine salt, or any combination thereof to form a second mixture; and spray drying the second mixture to form a plurality of particles that define the nicotine-containing powder. The method may further include adding at least one of a pH modifier and an antioxidant to the second mixture. When the solvent includes water, an inlet temperature ranges from 120° C. to 210° C. and an initial product temperature ranges from 25° C. to 100° C. When the solvent includes ethanol, the inlet temperature ranges from 65° C. to 180° C. and an initial product temperature ranges from 25° C. to 79° C.
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