公开(公告)号：US20220313614A1

公开(公告)日：2022-10-06

申请号：US17223746

申请日：2021-04-06

Applicant: Altria Client Services LLC

Inventor： Feng GAO ,  Benjamin L. RAGLAND ,  David J. PHILLIPS ,  Rebecca M. GRAY ,  Pauline MARCQ ,  Christian SCHUH ,  Krasnodara N. CAMERON

IPC: A61K9/50 ,  A61K9/00 ,  A61K31/465 ,  A61K47/26

Abstract: A method for forming encapsulated nicotine granules (ENGs) includes heating a first mixture to form a molten mixture, the first mixture includes one or more polyols; cooling the molten mixture to a first temperature to form a cooled molten mixture; adding at least one of nicotine and one or more nicotine salts to the cooled molten mixture to form a second mixture; cooling the second mixture to a second temperature to form one or more solidified structures, where the second temperature is different from the first temperature; and fragmenting the one or more solidified structures so as to form a plurality of encapsulated nicotine granules. The first temperature may be between about 120° C. and about 200° C. The second temperature may be below a glass transition temperature (Tg) of the one or more polyols. For example, the second temperature may be between about 65° C. and about 200° C.