公开(公告)号：US20040024307A1

公开(公告)日：2004-02-05

申请号：US10395002

申请日：2003-03-24

申请人： Amersham Health AS

发明人： Klaes Golman ,  Oskar Axelsson ,  Haukur Johanneson ,  Charlotte Olofsson ,  Sven Mansson ,  Stefan Petersson

IPC分类号： A61B005/05

CPC分类号： A61K49/06 ,  A61K49/08 ,  A61K49/10 ,  A61K49/18 ,  A61K49/1815 ,  G01R33/5601 ,  G01R33/62

摘要： The invention provides a method of magnetic resonance investigation of a sample, said method comprising: (i) reacting para-hydrogen enriched hydrogen with a hydrogenatable MR imaging agent precursor containing a non-hydrogen non-zero nuclear spin nucleus to produce a hydrogenated MR imaging agent; (ii) administering said hydrogenated MR imaging agent to said sample; (iii) exposing said sample to radiation of a frequency selected to excite nuclear spin transitions of said non-zero nuclear spin nucleus in said hydrogenated MR imaging agent; (v) detecting magnetic resonance signals of said non-zero nuclear spin nucleus from said sample; and (vi) optionally, generating an image or biological functional data or dynamic flow data from said detected signals.

摘要翻译： 本发明提供了一种对样品进行磁共振研究的方法，所述方法包括：（i）将富氢氢与含有非氢非零核自旋核的可氢化MR成像剂前体反应以产生氢化MR成像 代理人 （ii）将所述氢化MR成像剂施用于所述样品; （iii）将所述样品暴露于所选择的频率的辐射以激发所述氢化MR成像剂中所述非零核自旋核的核自旋跃迁; （v）从所述样品检测所述非零核自旋核的磁共振信号; 和（vi）可选地，从所述检测到的信号生成图像或生物功能数据或动态流量数据。