公开(公告)号：US20230390419A1

公开(公告)日：2023-12-07

申请号：US18450737

申请日：2023-08-16

申请人： Imam Abdulrahman Bin Faisal University

发明人： B. Rabindran JERMY ,  Vijaya RAVINAYAGAM

IPC分类号： A61K49/04 ,  A61K49/18 ,  A61K49/08 ,  A61K47/68 ,  A61K47/69 ,  A61K31/12 ,  A61P35/00

CPC分类号： A61K49/0428 ,  A61K49/1878 ,  A61K49/08 ,  A61K47/6803 ,  B82Y5/00 ,  A61K47/6929 ,  A61K31/12 ,  A61P35/00 ,  A61K47/6883 ,  A61K47/6923

摘要： Silica nanocarriers hybridized with superparamagnetic iron oxide nanoparticles (“SPIONs”) and curcumin through equilibrium or enforced adsorption technique. Methods for dual delivery of SPIONs and curcumin to a target for diagnosis or therapy, for example, for SPION-based magnetic resonance imaging or for targeted delivery of curcumin to a cell or tissue. The technique can be extend to co-precipitation of mixed metal oxide involving Ni, Mn, Co and Cu oxide. The calcination temperature can be varied from 500-900° C. The nanocombination is functionalized with chitosan, polyacrylic acid, PLGA or another agent to increase its biocompatibility in vivo.

公开(公告)号：US11793892B2

公开(公告)日：2023-10-24

申请号：US17348911

申请日：2021-06-16

申请人： Imam Abdulrahman Bin Faisal University

发明人： B. Rabindran Jermy ,  Vijaya Ravinayagam

IPC分类号： A61K9/00 ,  A61K49/04 ,  A61K49/18 ,  A61K49/08 ,  A61K47/68 ,  A61K47/69 ,  A61K31/12 ,  A61P35/00 ,  B82Y5/00

CPC分类号： A61K49/0428 ,  A61K31/12 ,  A61K47/6803 ,  A61K47/6883 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/08 ,  A61K49/1878 ,  A61P35/00 ,  B82Y5/00

摘要： Silica nanocarriers hybridized with superparamagnetic iron oxide nanoparticles (“SPIONs”) and curcumin through equilibrium or enforced adsorption technique. Methods for dual delivery of SPIONs and curcumin to a target for diagnosis or therapy, for example, for SPION-based magnetic resonance imaging or for targeted delivery of curcumin to a cell or tissue. The technique can be extend to co-precipitation of mixed metal oxide involving Ni, Mn, Co and Cu oxide. The calcination temperature can be varied from 500-900° C. The nanocombination is functionalized with chitosan, polyacrylic acid, PLGA or another agent to increase its biocompatibility in vivo.

公开(公告)号：US20170196997A1

公开(公告)日：2017-07-13

申请号：US15314339

申请日：2014-06-10

申请人： PEKING UNIVERSITY

发明人： Lingdong SUN ,  Chunhua YAN ,  Xiaoyu ZHENG

IPC分类号： A61K49/18 ,  A61K49/12 ,  A61K49/10

CPC分类号： A61K49/1824 ,  A61K49/08 ,  A61K49/10 ,  A61K49/126 ,  A61K49/1806 ,  A61K49/1836 ,  A61K49/1854 ,  A61K49/1857

摘要： A rare earth-based nanoparticle magnetic resonance contrast agent and a preparation method thereof are provided. The rare earth-based nanoparticle magnetic resonance contrast agent is rare earth-based inorganic nanoparticles having the surfaces coated with hydrophilic ligands. The rare earth-based nanoparticles are first obtained by a high-temperature oil phase reaction, and then the surfaces thereof are coated with hydrophilic molecules to obtain the rare earth-based nanoparticle magnetic resonance contrast agent. Compared with the existing clinical contrast agent, the magnetic resonance contrast agent of the present invention has a greatly improved relaxivity, a good imaging effect, a low required injection dose, and long in vivo residence time. In addition, the rigid structure of the inorganic nanoparticles can effectively reduce the leakage possibility of gadolinium ions.

公开(公告)号：US20170136133A1

公开(公告)日：2017-05-18

申请号：US15418304

申请日：2017-01-27

申请人： ApaTech Limited ,  University Court of the University of Aberdeen

发明人： Iain Ronald Gibson ,  Janet Mabel Scott Skakle ,  Nigel Smith ,  Thomas Buckland

IPC分类号： A61K49/08 ,  A61K49/18 ,  A61L27/42 ,  A61L27/02

CPC分类号： A61K49/08 ,  A61K49/00 ,  A61K49/1803 ,  A61L27/025 ,  A61L27/425 ,  A61L2430/02 ,  C01B25/32

摘要： A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprises a compound having the general chemical formula: Ca10−yGdy(PO4)6−x(SiO4)x(OH)2−c+y where 0

公开(公告)号：US09561960B2

公开(公告)日：2017-02-07

申请号：US12303951

申请日：2007-06-07

申请人： Iain Ronald Gibson ,  Janet Mabel Scott Skakle ,  Nigel Smith ,  Thomas Buckland

发明人： Iain Ronald Gibson ,  Janet Mabel Scott Skakle ,  Nigel Smith ,  Thomas Buckland

IPC分类号： C01B25/32 ,  A61K49/00 ,  A61K49/08

CPC分类号： A61K49/08 ,  A61K49/00 ,  A61K49/1803 ,  A61L27/025 ,  A61L27/425 ,  A61L2430/02 ,  C01B25/32

摘要： A synthetic calcium phosphate-based biomedical material comprising gadolinium. The material may comprise a compound having the general chemical formula: Ca10−yGdy(PO4)6−x(SiO4)x(OH)2−x+y where 0

摘要翻译： 一种包含钆的合成的基于磷酸钙的生物医学材料。 该材料可以包含具有以下通式的化合物：Ca10-yGy（PO4）6-x（SiO4）x（OH）2-x + y，其中0

公开(公告)号：US20160199517A1

公开(公告)日：2016-07-14

申请号：US14992847

申请日：2016-01-11

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Phillip C. Yang ,  Rajesh Dash

IPC分类号： A61K49/10

CPC分类号： A61K49/08

摘要： The methods of the invention exploit the capabilities of manganese-enhanced MRI (MEMRI), which provides viability-specific biological contrast agent through the intracellular accumulation of Mn2+. A typical contrast agent utilizes non-chelated Mn2+ in combination with Ca2+, e.g. as calcium gluconate. Active intracellular accumulation of Mn2+ generates high signal from the viable cells in normal tissue, or normal regions of heterogeneous tissue; no signal from the non-viable cells; and intermediate signal from viable but injured cells. The intermediate signal defines a “gray zone” of potentially salvageable cells.

摘要翻译： 本发明的方法利用锰增强MRI（MEMRI）的能力，其通过Mn2 +的细胞内积累提供生存特异性生物造影剂。 典型的造影剂使用非螯合Mn2 +与Ca2 +组合，例如， 如葡萄糖酸钙。 Mn2 +的活跃细胞内积累从正常组织中的活细胞或异质组织的正常区域产生高信号; 没有来自非活细胞的信号; 和来自活的但受损的细胞的中间信号。 中间信号定义了潜在可抢救细胞的“灰色区域”。

公开(公告)号：US09340581B2

公开(公告)日：2016-05-17

申请号：US14308419

申请日：2014-06-18

申请人： Dennis E. Hallahan ,  Shimian Qu ,  Zhaozhong Han

发明人： Dennis E. Hallahan ,  Shimian Qu ,  Zhaozhong Han

IPC分类号： A61K51/00 ,  A61K36/14 ,  C07K7/08 ,  A61K41/00 ,  A61K51/08 ,  A61K51/12 ,  C07K16/18 ,  C07K16/44 ,  A61K47/42 ,  A61K49/00 ,  A61N5/10 ,  C07K2/00 ,  A61K38/08 ,  A61K38/03 ,  A61K49/08 ,  A61K49/14 ,  C07K7/06

CPC分类号： A61K41/00 ,  A61K38/03 ,  A61K38/08 ,  A61K41/0038 ,  A61K47/42 ,  A61K47/48246 ,  A61K47/48815 ,  A61K47/64 ,  A61K47/6911 ,  A61K49/0002 ,  A61K49/08 ,  A61K49/14 ,  A61K51/08 ,  A61K51/082 ,  A61K51/088 ,  A61K51/1255 ,  A61N5/10 ,  C07K2/00 ,  C07K7/06 ,  C07K7/08 ,  C07K16/18 ,  C07K16/44 ,  C07K2317/622

摘要： A method for identifying a molecule that binds an irradiated tumor in a subject and molecules identified thereby. In some embodiments, the method includes the steps of (a) exposing a tumor to ionizing radiation; (b) administering to a subject a library of diverse molecules; and (c) isolating from the tumor one or more molecules of the library of diverse molecules, whereby a molecule that binds an irradiated tumor is identified. Also provided are targeting ligands that bind an irradiated tumor and therapeutic and diagnostic methods that employ the disclosed targeting ligands.

公开(公告)号：US20160038727A1

公开(公告)日：2016-02-11

申请号：US14527369

申请日：2014-10-29

申请人： The Trustees of the University of Pennsylvania

发明人： Kiarash Emami ,  Stephen J. Kadlecek ,  Rahim R. Rizi ,  Masaru Ishii ,  Hooman Hamedani

IPC分类号： A61M31/00 ,  A61M16/06 ,  A61K49/08 ,  A61M16/20 ,  A61M16/04 ,  G01R33/56 ,  A61M16/12 ,  A61M16/08

CPC分类号： A61M31/005 ,  A61B5/055 ,  A61B5/0813 ,  A61K49/08 ,  A61M16/0488 ,  A61M16/06 ,  A61M16/0833 ,  A61M16/0875 ,  A61M16/12 ,  A61M16/122 ,  A61M16/202 ,  A61M16/204 ,  A61M16/208 ,  A61M2016/003 ,  A61M2016/0039 ,  A61M2202/0007 ,  A61M2202/02 ,  A61M2202/0208 ,  A61M2202/0291 ,  A61M2205/3303 ,  A61M2230/42 ,  G01R33/5601

摘要： Systems and methods for delivering a gaseous contrast agent to the lungs of a subject.

摘要翻译： 将气体造影剂递送到受试者的肺的系统和方法。

公开(公告)号：US20160022485A1

公开(公告)日：2016-01-28

申请号：US14766735

申请日：2014-02-06

申请人： EMMETROPE OPHTHALMICS LLC

发明人： Jeffrey L. GOLDBERG ,  Roger A. GOLDBERG

IPC分类号： A61F9/00 ,  A61N2/00 ,  A61N2/06 ,  A61K49/08 ,  A61M37/00 ,  A61B5/05 ,  A61M5/00 ,  A61K35/30 ,  A61B3/13 ,  A61N2/02

CPC分类号： A61F9/0017 ,  A61B3/132 ,  A61B5/05 ,  A61B5/4839 ,  A61B90/20 ,  A61F9/00 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/0048 ,  A61K35/30 ,  A61K49/08 ,  A61M5/007 ,  A61M37/00 ,  A61M2037/0007 ,  A61N2/002 ,  A61N2/02 ,  A61N2/06

摘要： In certain aspects, the present invention is directed to a device selected from (a) an operating microscope with an attached or attachable magnet and (b) a magnet that is configured for attachment to an operating microscope. In either case, the magnet is configured to allow a patient's tissue to be viewed through the operating microscope while at the same time permitting the creation of a magnetic field of sufficient magnitude and direction to move a magnetic therapeutic and/or diagnostic agent lying within the tissue to a preferred location in the tissue.

摘要翻译： 在某些方面，本发明涉及一种选自（a）具有附接或可附接磁体的操作显微镜和（b）被配置为附接到操作显微镜的磁体的装置。 在任一种情况下，磁体构造成允许通过操作显微镜观察患者组织，同时允许产生足够大小和方向的磁场，以移动位于该位置内的磁性治疗和/或诊断剂 组织到组织中的优选位置。

公开(公告)号：US08940275B2

公开(公告)日：2015-01-27

申请号：US13819018

申请日：2011-09-08

申请人： Songping D. Huang ,  Yongxiu Li ,  James P. Basilion ,  Jihua Hao ,  Christopher Flask

发明人： Songping D. Huang ,  Yongxiu Li ,  James P. Basilion ,  Jihua Hao ,  Christopher Flask

IPC分类号： A61B5/055 ,  A61K49/08 ,  A61K49/06 ,  A61B6/00 ,  A61K49/18

CPC分类号： A61K49/08 ,  A61B5/055 ,  A61B6/481 ,  A61K49/06 ,  A61K49/18

摘要： An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.

摘要翻译： 用于生物系统成像或将药物递送到包括由至少一种钆配位聚合物形成的一种或多种纳米颗粒的生物系统的试剂。