公开(公告)号：US20220363694A1

公开(公告)日：2022-11-17

申请号：US17266466

申请日：2019-08-13

Applicant: Amgen Inc. ,  Carmot Therapeutics, Inc.

Inventor： John R. BUTLER ,  Daniel ERLANSON ,  Russell GRACEFFA ,  Jeffrey IWIG ,  Joon Won JEONG ,  Ryan D. WHITE ,  Yongwei WU ,  Shuyan YI ,  Xiao Mei ZHENG ,  Jesse M. MCFARLAND ,  Abhisek BANERJEE

IPC: C07D519/00 ,  C07D487/18

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：US20200165231A1

公开(公告)日：2020-05-28

申请号：US16687546

申请日：2019-11-18

Applicant: Amgen Inc.

Inventor： Youngsook SHIN ,  Victor J. CEE ,  Christopher M. TEGLEY ,  Brian Alan LANMAN ,  Ryan Paul WURZ ,  Kevin C. YANG ,  Vu Van MA ,  Daniel ERLANSON ,  Joon Won JEONG ,  Raymond V. FUCINI ,  Jeffrey IWIG

IPC: C07D403/14 ,  C07D487/04 ,  C07D403/12 ,  C07D498/04 ,  C07D471/04 ,  C07D417/14 ,  C07D401/14 ,  A61P35/00

Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.