公开(公告)号：US09988457B2

公开(公告)日：2018-06-05

申请号：US15048777

申请日：2016-02-19

Applicant: Amgen Inc.

Inventor： Kenneth Allan Brasel ,  James F. Smothers ,  Douglas Pat Cerretti

IPC: C07K16/28 ,  C07H21/04 ,  C07K14/715 ,  C07K16/18 ,  A61K39/00

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K14/7153 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-1, reduce monocyte migration into tumors, and reduce the accumulation of tumor-associated macrophages.

公开(公告)号：US09303084B2

公开(公告)日：2016-04-05

申请号：US13967037

申请日：2013-08-14

Applicant: AMGEN INC.

Inventor： Kenneth Allan Brasel ,  James F Smothers ,  Douglas Pat Cerretti

IPC: A61K39/00 ,  A61K39/395 ,  C12N5/16 ,  C07K16/00 ,  C12P21/08 ,  C07K16/18 ,  C07K14/715 ,  C07K16/28

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K14/7153 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/41 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antigen binding proteins that bind to human c-fms protein are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of c-fms to CSF-1, reduce monocyte migration into tumors, and reduce the accumulation of tumor-associated macrophages.

Abstract translation: 提供了结合人c-fms蛋白的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可抑制c-fms与CSF-1的结合，减少单核细胞向肿瘤的迁移，并减少肿瘤相关巨噬细胞的积累。