公开(公告)号：US11708341B2

公开(公告)日：2023-07-25

申请号：US16327079

申请日：2017-08-03

Applicant: Amgen Inc.

Inventor： Matthew Beaver ,  Sheng Cui ,  Xiangqing Shi

IPC: C07D301/12 ,  B01J31/16 ,  C07D303/36

CPC classification number: C07D301/12 ,  B01J31/1616 ,  B01J2531/72 ,  C07D303/36

Abstract: The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure




Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.