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公开(公告)号：US09988354B2
公开(公告)日：2018-06-05
申请号：US14773436
申请日：2014-03-14
申请人： AMGEN INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo
IPC分类号： A61K31/496 , A61K47/38 , C07D213/75 , A61K9/20
CPC分类号： C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use. Omecamtiv mecarbil (AMG 423, CK-1827452), having the structure:
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公开(公告)号：US11472773B2
公开(公告)日：2022-10-18
申请号：US16920144
申请日：2020-07-02
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn D. Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C. S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： A61P9/00 , A61P9/04 , C07D213/75 , A61K47/38 , A61K31/496 , A61K9/20
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US11465969B2
公开(公告)日：2022-10-11
申请号：US17263224
申请日：2019-08-16
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Henry Morrison , Sheng Cui , Kyle Quasdorf , Evelyn Yanez , Bin Peter Quan , Ron C. Kelly , Sebastien Caille , Lingyun Xiao , David Pearson , Jaclyn Raeburn , Ailsa Golightly , Bradley Morgan , Matthew Peterson , Alex Eberlin , Alexander Oblezov
IPC分类号： C07D213/75
摘要： Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：US20200079736A1
公开(公告)日：2020-03-12
申请号：US16684216
申请日：2019-11-14
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C.S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： C07D213/75 , A61K47/38 , A61K31/496 , A61K9/20
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US20210221771A1
公开(公告)日：2021-07-22
申请号：US17263224
申请日：2019-08-16
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Henry Morrison , Sheng Cui , Kyle Quasdorf , Evelyn Yanez , Bin Peter Quan , Ron C. Kelly , Sebastien Caille , Lingyun Xiao , David Pearson , Jaclyn Raeburn , Ailsa Golightly , Bradley Morgan , Matthew Peterson , Alex Eberlin , Alexander Oblezov
IPC分类号： C07D213/75
摘要： Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：US10858389B2
公开(公告)日：2020-12-08
申请号：US15561009
申请日：2016-03-25
申请人： Amgen Inc.
发明人： Sheng Cui , Krishnakumar Ranganathan , Richard Crockett , Ying Chen , Aleksander Swietlow , Kevin Crossley , Yun Shi , Karel Decroos , Etienne Moniotte
摘要： The instant disclosure is directed to solution phase fragment coupling methods for preparing etelcalcetide and its pharmaceutically acceptable salts.
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公开(公告)号：US20180312469A1
公开(公告)日：2018-11-01
申请号：US15963529
申请日：2018-04-26
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： C07D213/75 , A61K9/20 , A61K31/496 , A61K47/38
CPC分类号： C07D213/75 , A61K9/2013 , A61K9/2018 , A61K9/2054 , A61K31/496 , A61K47/38
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US11926592B2
公开(公告)日：2024-03-12
申请号：US17929645
申请日：2022-09-02
申请人： Amgen Inc.
发明人： Henry Morrison , Sheng Cui , Kyle Quasdorf , Evelyn Yanez , Bin Peter Quan , Ron C. Kelly , Sebastien Caille , Lingyun Xiao , David Pearson , Jaclyn Raeburn , Alisa Golightly
IPC分类号： C07D213/75
CPC分类号： C07D213/75 , C07B2200/13
摘要： Provided herein are free base crystalline forms, crystalline salts, and an amorphous salts of omecamtiv mecarbil.
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公开(公告)号：US20200331859A1
公开(公告)日：2020-10-22
申请号：US16920155
申请日：2020-07-02
申请人： AMGEN INC. , CYTOKINETICS, INC.
发明人： Sheng Cui , Henry Morrison , Karthik Nagapudi , Shawn Walker , Charles Bernard , Karl Bennett Hansen , Neil Fred Langille , Alan Martin Allgeier , Steven Mennen , Jacqueline C.S. Woo , Bradley Paul Morgan , Alex Muci
IPC分类号： C07D213/75 , A61K9/20 , A61K31/496 , A61K47/38
摘要： Provided are omecamtiv mecarbil dihydrochloride salt forms, compositions and pharmaceutical formulations thereof, and methods for their preparation and use.
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公开(公告)号：US11708341B2
公开(公告)日：2023-07-25
申请号：US16327079
申请日：2017-08-03
申请人： Amgen Inc.
发明人： Matthew Beaver , Sheng Cui , Xiangqing Shi
IPC分类号： C07D301/12 , B01J31/16 , C07D303/36
CPC分类号： C07D301/12 , B01J31/1616 , B01J2531/72 , C07D303/36
摘要： The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure
Compound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.
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