公开(公告)号：US20220235045A1

公开(公告)日：2022-07-28

申请号：US17612717

申请日：2020-05-20

Applicant: Amgen Inc.

Inventor： Mary CHAVES ,  Ron C. KELLY ,  Prashant AGARWAL ,  Stephan D. PARENT ,  Darren Leonard REID ,  Roman SHIMANOVICH

IPC: C07D471/04 ,  A61P35/00

Abstract: The present invention provides a crystalline form and stable salts of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1- piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several hydrochloride salt forms, phosphate salt form, mesylate salt form, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.