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    SOLID STATE FORMS
    4.
    发明申请
    SOLID STATE FORMS 有权

    公开(公告)号：US20220235045A1

    公开(公告)日：2022-07-28

    申请号：US17612717

    申请日：2020-05-20

    Applicant: Amgen Inc.

    Inventor： Mary CHAVES ,  Ron C. KELLY ,  Prashant AGARWAL ,  Stephan D. PARENT ,  Darren Leonard REID ,  Roman SHIMANOVICH

    IPC: C07D471/04 ,  A61P35/00

    Abstract: The present invention provides a crystalline form and stable salts of 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-(2-propanyl)-3-pyridinyl)-4-((2S)-2-methyl-4-(2-propenoyl)-1- piperazinyl)pyrido[2,3-d]pyrimidin-2(1H)-one, including several hydrochloride salt forms, phosphate salt form, mesylate salt form, and solid state forms thereof, pharmaceutical compositions, and methods of treating a disease mediated by KRAS G12C inhibition.

    CRYSTALLINE FORMS OF N-(4-((3-(2-AMINO-4-PYRIMIDINYL)-2-PYRIDINYL)OXY)PHENYL)-4-(4-METHYL -2-THIENYL)-1-PHTHALAZINAMINE SALTS AND USES THEREOF
    5.
    发明申请
    CRYSTALLINE FORMS OF N-(4-((3-(2-AMINO-4-PYRIMIDINYL)-2-PYRIDINYL)OXY)PHENYL)-4-(4-METHYL -2-THIENYL)-1-PHTHALAZINAMINE SALTS AND USES THEREOF 审中-公开
    N-（4 - （（3-（2-氨基-4-吡啶基）-2-吡啶基）氧基）苯基）-4-（4-甲基-2-苯乙基）-1-苯基]胺盐的结晶形式及其用途

    公开(公告)号：US20160304504A1

    公开(公告)日：2016-10-20

    申请号：US15101373

    申请日：2014-11-25

    Applicant: AMGEN INC.

    Inventor： Mary CHAVES ,  Matthew BIO ,  Matthew PETERSON

    IPC: C07D409/14 ,  C07C309/30 ,  C07C309/04

    CPC classification number: C07D409/14 ,  C07B2200/13 ,  C07C309/04 ,  C07C309/30

    Abstract: The present invention relates to crystalline forms and co-crystal forms of pharmaceutically acceptable salts of the compound, N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine (AMG 900, and pharmaceutical compositions comprising said crystalline and co-crystal forms thereof. The invention further provides uses of the crystalline forms and compositions, to treat cancer, including various types of solid tumors and hematologic cancer including myeloma and leukemia.

    Abstract translation: 本发明涉及化合物N-（4 - （（3-（2-氨基-4-嘧啶基）-2-吡啶基）氧基）苯基）-4-甲基苯甲酸的药学上可接受的盐的结晶形式和共晶形式， （4-甲基-2-噻吩基）-1-酞嗪胺（AMG 900和包含其结晶和共晶形式的药物组合物）本发明还提供了结晶形式和组合物用于治疗癌症的用途，包括各种类型 实体肿瘤和血液癌，包括骨髓瘤和白血病。

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