公开(公告)号：US08710087B2

公开(公告)日：2014-04-29

申请号：US13198287

申请日：2011-08-04

申请人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

发明人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

IPC分类号： A61K31/426

CPC分类号： C07D277/12 ,  C07D277/10

摘要： Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

公开(公告)号：US08829197B2

公开(公告)日：2014-09-09

申请号：US13042193

申请日：2011-03-07

申请人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

发明人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

IPC分类号： C07D277/10

CPC分类号： C07D277/12 ,  C07D277/10

摘要： Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

摘要翻译： 本文公开了脱氮代硫代聚醚（DADFT-PE）类似物的新盐和多晶型物，以及包含它们的药物组合物及其作为用于治疗疾病的金属螯合剂的应用。 还提供了人或动物受试者中铁和其他金属的螯合方法用于治疗金属过载和毒性。

公开(公告)号：US08846731B2

公开(公告)日：2014-09-30

申请号：US13267285

申请日：2011-10-06

申请人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

发明人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

IPC分类号： A61K31/426 ,  C07D277/10 ,  C07D277/12

CPC分类号： C07D277/12 ,  C07D277/10

摘要： Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogs, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

摘要翻译： 本文公开了脱氮代硫代聚醚（DADFT-PE）类似物的新盐和多晶型物，以及包含它们的药物组合物及其作为用于治疗疾病的金属螯合剂的应用。 还提供了人或动物受试者中铁和其他金属的螯合方法用于治疗金属过载和毒性。

公开(公告)号：US20120270911A1

公开(公告)日：2012-10-25

申请号：US13267285

申请日：2011-10-06

申请人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

发明人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

IPC分类号： C07D277/10 ,  A61P39/04 ,  A61K31/426

CPC分类号： C07D277/12 ,  C07D277/10

摘要： Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

摘要翻译： 本文公开了脱氮代硫代聚醚（DADFT-PE）类似物的新盐和多晶型物，以及包含它们的药物组合物及其作为用于治疗疾病的金属螯合剂的应用。 还提供了人或动物受试者中铁和其他金属的螯合方法用于治疗金属过载和毒性。

公开(公告)号：US08063227B2

公开(公告)日：2011-11-22

申请号：US12502559

申请日：2009-07-14

申请人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

发明人： Amy E. Tapper ,  Hugh Y. Rienhoff, Jr. ,  Stephan D. Parent ,  Patricia Andres ,  Jason A. Hanko ,  Huamin Zhang

IPC分类号： C07D277/10

CPC分类号： C07D277/12 ,  C07D277/10

摘要： Disclosed herein are new salts and polymorphs of desazadesferrithiocin polyether (DADFT-PE) analogues, as well as pharmaceutical compositions comprising them and their application as metal chelation agents for the treatment of disease. Methods of chelation of iron and other metals in a human or animal subject are also provided for the treatment of metal overload and toxicity.

摘要翻译： 本文公开了脱氮代硫代聚醚（DADFT-PE）类似物的新盐和多晶型物，以及包含它们的药物组合物及其作为用于治疗疾病的金属螯合剂的应用。 还提供了人或动物受试者中铁和其他金属的螯合方法用于治疗金属过载和毒性。