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1.发明申请Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases 有权使用二氨基嘧啶P2X3和P2X2 / 3受体调节剂治疗呼吸道和胃肠道疾病的方法公开(公告)号：US20070049609A1
公开(公告)日：2007-03-01
申请号：US11509921
申请日：2006-08-25
申请人： Chris Broka , David Carter , Michael Dillon , Anthony Ford , Ronald Hawley , Alam Jahangir , Amy Moore , Daniel Parish
发明人： Chris Broka , David Carter , Michael Dillon , Anthony Ford , Ronald Hawley , Alam Jahangir , Amy Moore , Daniel Parish
IPC分类号： A61K31/513
CPC分类号： A61K31/506 , A61K31/505 , A61K31/513 , A61K31/538 , Y10S514/826
摘要： Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X 3和/或P2X 3/3受体拮抗剂介导的呼吸道和胃肠道疾病的方法，所述方法包括向有需要的受试者施用有效量 的式（I）化合物或其药学上可接受的盐，其中D，X，Y，R 1，R 2，R 3， R 4，R 4，R 5，R 6，R 7和R 8， SUP>如本文所定义。
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公开(公告)号：US11351381B2
公开(公告)日：2022-06-07
申请号：US16415311
申请日：2019-05-17
申请人： Eric Leuthardt , Daniel Moran , Matthew MacEwan , Amy Moore , Paige Cloonan , Yidan Qin , Christopher Zhang , Ashwin Kamath , Wilson Ray
发明人： Eric Leuthardt , Daniel Moran , Matthew MacEwan , Amy Moore , Paige Cloonan , Yidan Qin , Christopher Zhang , Ashwin Kamath , Wilson Ray
摘要： A system for stimulating a sympathetic chain includes an electrode assembly that is configured to attach to a bone in proximity to a targeted portion of the sympathetic chain. The electrode assembly includes a cathode and an anode. The system also includes a power supply connected to the electrode assembly and configured to deliver power to the electrode assembly. The electrode assembly generates an electrical field between the cathode and the anode when power is delivered to the electrode assembly. The electrical field reaches the targeted portion of the sympathetic chain to provide electrical stimulation to the targeted portion of the sympathetic chain.
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公开(公告)号：US20070049758A1
公开(公告)日：2007-03-01
申请号：US11510216
申请日：2006-08-25
申请人： Michael Dillon , Alam Jahangir , Amy Moore , Paul Wagner
发明人： Michael Dillon , Alam Jahangir , Amy Moore , Paul Wagner
IPC分类号： C07D239/46 , C07D403/02
CPC分类号： C07D239/48
摘要： Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要翻译： 用于治疗由P2X 3和/或P2X 3/3受体拮抗剂介导的疾病的化合物和方法，所述方法包括向有需要的受试者施用有效量的 式（I）的化合物：其中D，X，R 1，R 2，R 3，R 4， R 5，R 5，R 6，R 7和R 8如本文所定义。
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公开(公告)号：US20190351235A1
公开(公告)日：2019-11-21
申请号：US16415311
申请日：2019-05-17
申请人： Eric Leuthardt , Daniel Moran , Matthew MacEwan , Amy Moore , Paige Cloonan , Yidan Qin , Christopher Zhang , Ashwin Kamath , Wilson Ray
发明人： Eric Leuthardt , Daniel Moran , Matthew MacEwan , Amy Moore , Paige Cloonan , Yidan Qin , Christopher Zhang , Ashwin Kamath , Wilson Ray
摘要： A system for stimulating a sympathetic chain includes an electrode assembly that is configured to attach to a bone in proximity to a targeted portion of the sympathetic chain. The electrode assembly includes a cathode and an anode. The system also includes a power supply connected to the electrode assembly and configured to deliver power to the electrode assembly. The electrode assembly generates an electrical field between the cathode and the anode when power is delivered to the electrode assembly. The electrical field reaches the targeted portion of the sympathetic chain to provide electrical stimulation to the targeted portion of the sympathetic chain.
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