摘要:
Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要:
Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.
摘要:
An adhesive article includes a biocompatible and at least partially biodegradable substrate having a surface; and a plurality of protrusions extending from the surface. The protrusions include a biocompatible and at least partially biodegradable material, and have an average height of less than approximately 1,000 micrometers.
摘要:
A device for site monitoring is disclosed. The device may include a communication interface configured to receive site monitoring data from a site monitoring system. The communication interface may also be configured to wirelessly transmit the site monitoring data to a base station. The site monitoring data may include a device identification. The device also may include a processor and memory. The memory also may include two pseudonoise (PN) codes, namely a first PN code and a second PN code. The site monitoring data may be received from the site monitoring system. The site monitoring data may be spread using the first PN code to provide first spread site monitoring data. The first spread site monitoring data may be spread using the second PN code to provide second spread site monitoring data. The second spread site monitoring data may be transmitted using a burst direct sequence spread spectrum radio signal.
摘要:
An interactive virtualization management system provides an assessment of proposed or existing virtualization schemes. A Virtual Technology Overhead Profile (VTOP) is created for each of a variety of configurations of host computer systems and virtualization technologies by measuring the overhead experienced under a variety of conditions. The multi-variate overhead profile corresponding to each target configuration being evaluated is used by the virtualization management system to determine the overhead that is to be expected on the target system, based on the particular set of conditions at the target system. Based on these overhead estimates, and the parameters of the jobs assigned to each virtual machine on each target system, the resultant overall performance of the target system for meeting the performance criteria of each of the jobs in each virtual machine is determined, and over-committed virtual machines and computer systems are identified.
摘要:
A maskless lithography system is disclosed that includes an array of focusing elements, each of which focuses an energy beam from an array of sources into an array of focal spots in order to create a permanent pattern on an adjacent substrate.
摘要:
A system and method are described for torrefaction of particulate biomass. The system comprises a reactor having mass flow characteristics, containing particulate biomass, and further is equipped with a heated gas input; a gas discharge output; a particulate solids inlet; and a particulate solids discharge.
摘要:
An interactive virtualization management system provides an assessment of proposed or existing virtualization schemes. A Virtual Technology Overhead Profile (VTOP) is created for each of a variety of configurations of host computer systems and virtualization technologies by measuring the overhead experienced under a variety of conditions. The multi-variate overhead profile corresponding to each target configuration being evaluated is used by the virtualization management system to determine the overhead that is to be expected on the target system, based on the particular set of conditions at the target system. Based on these overhead estimates, and the parameters of the jobs assigned to each virtual machine on each target system, the resultant overall performance of the target system for meeting the performance criteria of each of the jobs in each virtual machine is determined, and over-committed virtual machines and computer systems are identified.
摘要:
A connection device for connecting two turbine housings (1, 2) of a two-stage turbocharging system includes a male/female joint for joining the two turbine housings; a cylindrical ring seal (3) installed under compression inside the male/female joint for sealing exhaust gas; and a vibration damper (4) in a shape of a flat washer and placed between the two housings. The cylindrical ring seal can be made of stainless steel mesh impregnated with vermiculite or graphite. The vibration damper can be made of stainless steel mesh but not impregnated.
摘要:
A longitudinal mode resonator that includes a substrate and a bar that is suspended relative to the substrate. The bar is suspended such that it is free to expand and contract longitudinally in response to the application of an electric field across its thickness. The expansion and contraction of the bar achieves resonance in response to the field having a frequency substantially equal to the fundamental frequency of the bar.