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公开(公告)号：US20140219996A1
公开(公告)日：2014-08-07
申请号：US14234024
申请日：2012-07-20
IPC分类号： C07H23/00 , A61K45/06 , A61K31/7135
CPC分类号： C07H5/10 , A61K31/7135 , A61K45/06 , C07F15/0046 , C07H5/08 , C07H23/00 , Y02A50/411
摘要： The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
摘要翻译： 本发明提供式（I）的新型钌化合物：或其盐，异构体，水合物或溶剂合物或其组合; 其中E，R 1，R 2，R 3，R 4，R 5，X 1和X 2如本文所定义，及其药物组合物。 还提供了使用和治疗的方法。 已经发现这些化合物可用于治疗疟疾感染。 此类化合物还可用于治疗炎性病症，例如急性肺损伤和急性呼吸窘迫综合征，其任选地可能与疟疾感染相关。
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公开(公告)号：US09062089B2
公开(公告)日：2015-06-23
申请号：US14234024
申请日：2012-07-21
IPC分类号： C07H23/00 , A61K31/7135 , C07H5/08 , C07F15/00 , A61K45/06
CPC分类号： C07H5/10 , A61K31/7135 , A61K45/06 , C07F15/0046 , C07H5/08 , C07H23/00 , Y02A50/411
摘要： The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.
摘要翻译： 本发明提供式（I）的新型钌化合物：或其盐，异构体，水合物或溶剂合物或其组合; 其中E，R 1，R 2，R 3，R 4，R 5，X 1和X 2如本文所定义，及其药物组合物。 还提供了使用和治疗的方法。 已经发现这些化合物可用于治疗疟疾感染。 此类化合物还可用于治疗炎性病症，例如急性肺损伤和急性呼吸窘迫综合征，其任选地可能与疟疾感染相关。
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